Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011661537> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2011661537 endingPage "408" @default.
- W2011661537 startingPage "403" @default.
- W2011661537 abstract "In humans, treatment of malignant ascites with bolus TNF leads to resolution of the ascites. In an experimental model NMRI nude mice were inoculated intraperitoneally with human NIH-OVCAR3 adenocarcinoma cells, resulting in production of ascites and intraperitoneal tumor growth. Ascites formation and tumor growth after IP injection of recombinant human TNF was determined. Depending on the treatment schedule, a dual effect of TNF on the development of ascites was seen. Doses of TNF (1-10 μg/g) given once per week completely prevented ascites production, whereas the same doses of TNF given on a daily schedule induced enhanced ascites formation in an inverse TNF dose relationship. The area of tumor cell-covered peritoneal lining corresponded to these findings, indicating a correlation of tumor mass with ascites production. In an attempt to prevent renewal of ascites after drainage, neither inhibition nor enhancement in ascites production was seen when TNF was given five times per week. However, doses of 10 μg/g of TNF once per week led to almost complete inhibition of ascites reappearance. Histological examination of animals that received repeated TNF treatment demonstrated chronic peritonitis with strong stromal proliferation, angiogenesis, and increased adhesion of tumor cells to the peritoneum." @default.
- W2011661537 created "2016-06-24" @default.
- W2011661537 creator A5028984477 @default.
- W2011661537 creator A5048375096 @default.
- W2011661537 creator A5075822843 @default.
- W2011661537 creator A5077568309 @default.
- W2011661537 date "1996-05-01" @default.
- W2011661537 modified "2023-10-16" @default.
- W2011661537 title "Tumor Necrosis Factor Effects on Ascites Formation in an Experimental Tumor Model" @default.
- W2011661537 cites W1963746501 @default.
- W2011661537 cites W1972204562 @default.
- W2011661537 cites W1974292298 @default.
- W2011661537 cites W2025210771 @default.
- W2011661537 cites W2030254797 @default.
- W2011661537 cites W2075579539 @default.
- W2011661537 cites W2089459264 @default.
- W2011661537 cites W2123840402 @default.
- W2011661537 cites W2166867761 @default.
- W2011661537 cites W2174322658 @default.
- W2011661537 cites W4234554068 @default.
- W2011661537 doi "https://doi.org/10.1089/jir.1996.16.403" @default.
- W2011661537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8727081" @default.
- W2011661537 hasPublicationYear "1996" @default.
- W2011661537 type Work @default.
- W2011661537 sameAs 2011661537 @default.
- W2011661537 citedByCount "7" @default.
- W2011661537 crossrefType "journal-article" @default.
- W2011661537 hasAuthorship W2011661537A5028984477 @default.
- W2011661537 hasAuthorship W2011661537A5048375096 @default.
- W2011661537 hasAuthorship W2011661537A5075822843 @default.
- W2011661537 hasAuthorship W2011661537A5077568309 @default.
- W2011661537 hasConcept C126322002 @default.
- W2011661537 hasConcept C141071460 @default.
- W2011661537 hasConcept C142724271 @default.
- W2011661537 hasConcept C17991360 @default.
- W2011661537 hasConcept C2776001837 @default.
- W2011661537 hasConcept C2778536324 @default.
- W2011661537 hasConcept C2780199535 @default.
- W2011661537 hasConcept C2780496750 @default.
- W2011661537 hasConcept C502942594 @default.
- W2011661537 hasConcept C71924100 @default.
- W2011661537 hasConceptScore W2011661537C126322002 @default.
- W2011661537 hasConceptScore W2011661537C141071460 @default.
- W2011661537 hasConceptScore W2011661537C142724271 @default.
- W2011661537 hasConceptScore W2011661537C17991360 @default.
- W2011661537 hasConceptScore W2011661537C2776001837 @default.
- W2011661537 hasConceptScore W2011661537C2778536324 @default.
- W2011661537 hasConceptScore W2011661537C2780199535 @default.
- W2011661537 hasConceptScore W2011661537C2780496750 @default.
- W2011661537 hasConceptScore W2011661537C502942594 @default.
- W2011661537 hasConceptScore W2011661537C71924100 @default.
- W2011661537 hasIssue "5" @default.
- W2011661537 hasLocation W20116615371 @default.
- W2011661537 hasLocation W20116615372 @default.
- W2011661537 hasOpenAccess W2011661537 @default.
- W2011661537 hasPrimaryLocation W20116615371 @default.
- W2011661537 hasRelatedWork W123922204 @default.
- W2011661537 hasRelatedWork W126122945 @default.
- W2011661537 hasRelatedWork W2083010765 @default.
- W2011661537 hasRelatedWork W2353128710 @default.
- W2011661537 hasRelatedWork W2403644471 @default.
- W2011661537 hasRelatedWork W2419452665 @default.
- W2011661537 hasRelatedWork W2589043402 @default.
- W2011661537 hasRelatedWork W2775017441 @default.
- W2011661537 hasRelatedWork W292138561 @default.
- W2011661537 hasRelatedWork W4308429164 @default.
- W2011661537 hasVolume "16" @default.
- W2011661537 isParatext "false" @default.
- W2011661537 isRetracted "false" @default.
- W2011661537 magId "2011661537" @default.
- W2011661537 workType "article" @default.