FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011662441> ?p ?o ?g. }

• W2011662441 endingPage "e108444" @default.
• W2011662441 startingPage "e108444" @default.
• W2011662441 abstract "Different cancer cells exhibit altered sensitivity to metformin treatment. Recent studies suggest these findings may be due in part to the common cell culture practice of utilizing high glucose, and when glucose is lowered, metformin becomes increasingly cytotoxic to cancer cells. In low glucose conditions ranging from 0 to 5 mM, metformin was cytotoxic to breast cancer cell lines MCF7, MDAMB231 and SKBR3, and ovarian cancer cell lines OVCAR3, and PA-1. MDAMB231 and SKBR3 were previously shown to be resistant to metformin in normal high glucose medium. When glucose was increased to 10 mM or above, all of these cell lines become less responsive to metformin treatment. Metformin treatment significantly reduced ATP levels in cells incubated in media with low glucose (2.5 mM), high fructose (25 mM) or galactose (25 mM). Reductions in ATP levels were not observed with high glucose (25 mM). This was compensated by enhanced glycolysis through activation of AMPK when oxidative phosphorylation was inhibited by metformin. However, enhanced glycolysis was either diminished or abolished by replacing 25 mM glucose with 2.5 mM glucose, 25 mM fructose or 25 mM galactose. These findings suggest that lowering glucose potentiates metformin induced cell death by reducing metformin stimulated glycolysis. Additionally, under low glucose conditions metformin significantly decreased phosphorylation of AKT and various targets of mTOR, while phospho-AMPK was not significantly altered. Thus inhibition of mTOR signaling appears to be independent of AMPK activation. Further in vivo studies using the 4T1 breast cancer mouse model confirmed that metformin inhibition of tumor growth was enhanced when serum glucose levels were reduced via low carbohydrate ketogenic diets. The data support a model in which metformin treatment of cancer cells in low glucose medium leads to cell death by decreasing ATP production and inhibition of survival signaling pathways. The enhanced cytotoxicity of metformin against cancer cells was observed both in vitro and in vivo." @default.
• W2011662441 created "2016-06-24" @default.
• W2011662441 creator A5003498834 @default.
• W2011662441 creator A5045947216 @default.
• W2011662441 creator A5056934029 @default.
• W2011662441 creator A5089088029 @default.
• W2011662441 date "2014-09-25" @default.
• W2011662441 modified "2023-10-16" @default.
• W2011662441 title "Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo" @default.
• W2011662441 cites W1483212110 @default.
• W2011662441 cites W1606666119 @default.
• W2011662441 cites W1713068442 @default.
• W2011662441 cites W1972293641 @default.
• W2011662441 cites W1974130263 @default.
• W2011662441 cites W1987874136 @default.
• W2011662441 cites W1994504180 @default.
• W2011662441 cites W1995069275 @default.
• W2011662441 cites W1997270358 @default.
• W2011662441 cites W2007844375 @default.
• W2011662441 cites W2015396179 @default.
• W2011662441 cites W2023894209 @default.
• W2011662441 cites W2026967508 @default.
• W2011662441 cites W2050253616 @default.
• W2011662441 cites W2056161011 @default.
• W2011662441 cites W2063018637 @default.
• W2011662441 cites W2081076321 @default.
• W2011662441 cites W2084890278 @default.
• W2011662441 cites W2100511132 @default.
• W2011662441 cites W2105530711 @default.
• W2011662441 cites W2108281860 @default.
• W2011662441 cites W2118984773 @default.
• W2011662441 cites W2121173674 @default.
• W2011662441 cites W2123014930 @default.
• W2011662441 cites W2125747634 @default.
• W2011662441 cites W2135617839 @default.
• W2011662441 cites W2139271329 @default.
• W2011662441 cites W2141598854 @default.
• W2011662441 cites W2144209522 @default.
• W2011662441 cites W2146780639 @default.
• W2011662441 cites W2151191898 @default.
• W2011662441 cites W2158822657 @default.
• W2011662441 cites W2162401151 @default.
• W2011662441 cites W2164361361 @default.
• W2011662441 cites W2165673706 @default.
• W2011662441 cites W2324992560 @default.
• W2011662441 cites W4233394038 @default.
• W2011662441 doi "https://doi.org/10.1371/journal.pone.0108444" @default.
• W2011662441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177919" @default.
• W2011662441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25254953" @default.
• W2011662441 hasPublicationYear "2014" @default.
• W2011662441 type Work @default.
• W2011662441 sameAs 2011662441 @default.
• W2011662441 citedByCount "108" @default.
• W2011662441 countsByYear W20116624412015 @default.
• W2011662441 countsByYear W20116624412016 @default.
• W2011662441 countsByYear W20116624412017 @default.
• W2011662441 countsByYear W20116624412018 @default.
• W2011662441 countsByYear W20116624412019 @default.
• W2011662441 countsByYear W20116624412020 @default.
• W2011662441 countsByYear W20116624412021 @default.
• W2011662441 countsByYear W20116624412022 @default.
• W2011662441 countsByYear W20116624412023 @default.
• W2011662441 crossrefType "journal-article" @default.
• W2011662441 hasAuthorship W2011662441A5003498834 @default.
• W2011662441 hasAuthorship W2011662441A5045947216 @default.
• W2011662441 hasAuthorship W2011662441A5056934029 @default.
• W2011662441 hasAuthorship W2011662441A5089088029 @default.
• W2011662441 hasBestOaLocation W20116624411 @default.
• W2011662441 hasConcept C11960822 @default.
• W2011662441 hasConcept C121608353 @default.
• W2011662441 hasConcept C126322002 @default.
• W2011662441 hasConcept C134018914 @default.
• W2011662441 hasConcept C150903083 @default.
• W2011662441 hasConcept C154317977 @default.
• W2011662441 hasConcept C185592680 @default.
• W2011662441 hasConcept C20251656 @default.
• W2011662441 hasConcept C202751555 @default.
• W2011662441 hasConcept C207001950 @default.
• W2011662441 hasConcept C2776970464 @default.
• W2011662441 hasConcept C2777866211 @default.
• W2011662441 hasConcept C2779306644 @default.
• W2011662441 hasConcept C2780124434 @default.
• W2011662441 hasConcept C2780323712 @default.
• W2011662441 hasConcept C502942594 @default.
• W2011662441 hasConcept C55493867 @default.
• W2011662441 hasConcept C62231903 @default.
• W2011662441 hasConcept C71924100 @default.
• W2011662441 hasConcept C86803240 @default.
• W2011662441 hasConcept C96232424 @default.
• W2011662441 hasConcept C97029542 @default.
• W2011662441 hasConceptScore W2011662441C11960822 @default.
• W2011662441 hasConceptScore W2011662441C121608353 @default.
• W2011662441 hasConceptScore W2011662441C126322002 @default.
• W2011662441 hasConceptScore W2011662441C134018914 @default.
• W2011662441 hasConceptScore W2011662441C150903083 @default.
• W2011662441 hasConceptScore W2011662441C154317977 @default.
• W2011662441 hasConceptScore W2011662441C185592680 @default.
• W2011662441 hasConceptScore W2011662441C20251656 @default.

• next