Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011691008> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2011691008 endingPage "114" @default.
- W2011691008 startingPage "105" @default.
- W2011691008 abstract "The biological effects of neuropeptide Y (NPY), rat pancreatic polypeptide (rPP), hybrid analogs of NPY and PP, and C-terminal fragments of NPY were studied in the field-stimulated rat vas deferens model. The results were correlated with peptide binding experiments in Y1 and PP receptor assays on rat PC-12 cells and Y2 receptors on porcine hippocampal membranes. NPY and rPP inhibited the electrically induced contractions in the vas deferens with an IC50 of 25 and 22 nM respectively. However, in contrast to NPY, rPP could not totally block muscle activity. The inhibitory action of the long C-terminal fragment of NPY, NPY-(19-36) and NPY-(11-36), indicated that NPY acts through a Y2 receptor in the vas deferens. The structural basis for the differential recognition of NPY and PP by Y2 receptors and partly also by PP receptors, could be defined with hybrid analogs of PP and NPY. The analogs, [Ile31,Gln34]PP and [Leu31,Pro33]NPY reacted in the vas deferens preparation in accordance with their relative potency in the Y2 and PP receptor assays. [Ile31,Gln34]PP, which bound to the Y2 receptor like NPY, was also able to block the part of the contractile response which was resistant to rPP. It is concluded that in the vas deferens, PP-fold peptides act through two types of receptors: Y2 and PP, and that residues in the C-terminal part of the molecules determine the differential recognition of the peptides by these receptor types." @default.
- W2011691008 created "2016-06-24" @default.
- W2011691008 creator A5021396103 @default.
- W2011691008 creator A5073825346 @default.
- W2011691008 creator A5081077782 @default.
- W2011691008 date "1990-09-01" @default.
- W2011691008 modified "2023-10-17" @default.
- W2011691008 title "Structure-function studies on neuropeptide Y and pancreatic polypeptide — evidence for two PP-fold receptors in vas deferens" @default.
- W2011691008 cites W1662683252 @default.
- W2011691008 cites W1963931014 @default.
- W2011691008 cites W1964401857 @default.
- W2011691008 cites W1979228270 @default.
- W2011691008 cites W1984582568 @default.
- W2011691008 cites W1988628530 @default.
- W2011691008 cites W1990332976 @default.
- W2011691008 cites W1992719775 @default.
- W2011691008 cites W2003910692 @default.
- W2011691008 cites W2004140528 @default.
- W2011691008 cites W2012144732 @default.
- W2011691008 cites W2018100669 @default.
- W2011691008 cites W2025944726 @default.
- W2011691008 cites W2026136209 @default.
- W2011691008 cites W2026835141 @default.
- W2011691008 cites W2033183190 @default.
- W2011691008 cites W2034995830 @default.
- W2011691008 cites W2051549118 @default.
- W2011691008 cites W2052173587 @default.
- W2011691008 cites W2053807193 @default.
- W2011691008 cites W2059359171 @default.
- W2011691008 cites W2069860215 @default.
- W2011691008 cites W2071246615 @default.
- W2011691008 cites W2071574435 @default.
- W2011691008 cites W2071678855 @default.
- W2011691008 cites W2081149136 @default.
- W2011691008 cites W2087991042 @default.
- W2011691008 cites W2089280546 @default.
- W2011691008 cites W2094737697 @default.
- W2011691008 cites W2178951657 @default.
- W2011691008 doi "https://doi.org/10.1016/0014-2999(90)94065-6" @default.
- W2011691008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2178092" @default.
- W2011691008 hasPublicationYear "1990" @default.
- W2011691008 type Work @default.
- W2011691008 sameAs 2011691008 @default.
- W2011691008 citedByCount "49" @default.
- W2011691008 countsByYear W20116910082020 @default.
- W2011691008 crossrefType "journal-article" @default.
- W2011691008 hasAuthorship W2011691008A5021396103 @default.
- W2011691008 hasAuthorship W2011691008A5073825346 @default.
- W2011691008 hasAuthorship W2011691008A5081077782 @default.
- W2011691008 hasConcept C118303440 @default.
- W2011691008 hasConcept C126322002 @default.
- W2011691008 hasConcept C134018914 @default.
- W2011691008 hasConcept C170493617 @default.
- W2011691008 hasConcept C185592680 @default.
- W2011691008 hasConcept C2778108375 @default.
- W2011691008 hasConcept C2778210472 @default.
- W2011691008 hasConcept C2778563252 @default.
- W2011691008 hasConcept C71315377 @default.
- W2011691008 hasConcept C71924100 @default.
- W2011691008 hasConcept C86803240 @default.
- W2011691008 hasConcept C93984277 @default.
- W2011691008 hasConceptScore W2011691008C118303440 @default.
- W2011691008 hasConceptScore W2011691008C126322002 @default.
- W2011691008 hasConceptScore W2011691008C134018914 @default.
- W2011691008 hasConceptScore W2011691008C170493617 @default.
- W2011691008 hasConceptScore W2011691008C185592680 @default.
- W2011691008 hasConceptScore W2011691008C2778108375 @default.
- W2011691008 hasConceptScore W2011691008C2778210472 @default.
- W2011691008 hasConceptScore W2011691008C2778563252 @default.
- W2011691008 hasConceptScore W2011691008C71315377 @default.
- W2011691008 hasConceptScore W2011691008C71924100 @default.
- W2011691008 hasConceptScore W2011691008C86803240 @default.
- W2011691008 hasConceptScore W2011691008C93984277 @default.
- W2011691008 hasIssue "1" @default.
- W2011691008 hasLocation W20116910081 @default.
- W2011691008 hasLocation W20116910082 @default.
- W2011691008 hasOpenAccess W2011691008 @default.
- W2011691008 hasPrimaryLocation W20116910081 @default.
- W2011691008 hasRelatedWork W1979051058 @default.
- W2011691008 hasRelatedWork W1986631548 @default.
- W2011691008 hasRelatedWork W1988054489 @default.
- W2011691008 hasRelatedWork W1998180004 @default.
- W2011691008 hasRelatedWork W2003791055 @default.
- W2011691008 hasRelatedWork W2034183147 @default.
- W2011691008 hasRelatedWork W2039074868 @default.
- W2011691008 hasRelatedWork W2091575749 @default.
- W2011691008 hasRelatedWork W3045414151 @default.
- W2011691008 hasRelatedWork W66671487 @default.
- W2011691008 hasVolume "186" @default.
- W2011691008 isParatext "false" @default.
- W2011691008 isRetracted "false" @default.
- W2011691008 magId "2011691008" @default.
- W2011691008 workType "article" @default.