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- W2011695536 abstract "<h2>Abstract</h2> Peripheral plasma levels of progesterone, estradiol and d-norgestrel were determined by radioimmunoassay in five women using silastic intravaginal rings (IVR), homogenously impregnated with 50 mg of dl-norgestrel and in three women after oral intake of 250 and 30 μg of d-norgestrel. The radioimmunoassay for d-norgestrel utilized the crossreaction with a norethindrone antiserum. lodinated histamine was conjugated to d-norgestrel-3-(0-carboxymethyl)-oxime and the conjugate used as a tracer. It is concluded that this is a useful method for preparing a specific tracer for d-norgestrel. The plasma levels of progesterone and estradiol were depressed to early follicular phase levels during treatment with the IVRs. After an initial peak of 2.9–8.5 ng/ml on day 2–4, d-norgestrel levels decreased to 0.7–4.0 ng/ml at the end of treatment. Oral administration of 250 and 30 μg of d-norgestrel gave rise to peak plasma levels of 4–7 ng/ml and 1.1–2.8 ng/ml, respectively. The initial plasma half-life of d-norgestrel was found to be approximately three hours and the second half-life about 18 hours. A comparison between the plasma levels of d-norgestrel reached in women using IVRs and the levels reached after oral ingestion of d-norgestrel indicate that the rings used, during the main period of treatment, deliver more dnorgestrel than is needed for contraceptive purposes." @default.
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- W2011695536 title "Peripheral plasma levels of d-norgestrel in women after oral administration of d-norgestrel and when using intravaginal rings impregnated with dl-norgestrel" @default.
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- W2011695536 doi "https://doi.org/10.1016/0010-7824(75)90087-6" @default.
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