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• W2011697599 abstract "Purpose: To describe corneal changes visible on in vivo confocal microscopy, in patients with debilitating ocular sequelae because of toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome (SJS). Patients and Methods: Forty-one eyes of 25 consecutive patients suffering from chronic TEN or SJS were studied using in vivo confocal microscopy. Results: Severe dry eye syndrome with no associated limbal stem cell deficiency (25 eyes, 16 patients, 61%) was the most frequent clinical pattern. Limbal stem cell deficiency was noted in 16 eyes (12 patients, 39%). Three patients had asymmetric disease. Confocal microscopy showed a consistent change in the superficial epithelial cells in both clinical presentations. Patients with dry eye syndrome had frequent pathological nerve damages, and the presence of dendritic cells was prevalent (65%). Inflammatory cells were observed in a large number in 4 of the 12 patients presenting neovascularization of the cornea. Conclusions: The corneas of patients with chronic ocular sequelae linked to SJS and TEN present a number of abnormalities. In vivo confocal microscopy is a potentially useful tool for therapeutic indications and for follow-up of the debilitating chronic ocular problems associated with these diseases." @default.
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• W2011697599 date "2009-05-01" @default.
• W2011697599 modified "2023-09-30" @default.
• W2011697599 title "In Vivo Confocal Microscopic Evaluation of Corneal Changes in Chronic Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis" @default.
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• W2011697599 doi "https://doi.org/10.1097/ico.0b013e31818cd299" @default.
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