Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011707399> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2011707399 endingPage "79" @default.
- W2011707399 startingPage "71" @default.
- W2011707399 abstract "Viral infections in animal models appear to be ideal systems for determining toxicity to the immune system by environmental substances. Since many viral infections that are utilized in animals produce systemic disease, these models provide an opportunity to evaluate the interaction between virus and components of host resistance. In these infections it is possible to delineate the role of antibody, interferon, cell-mediated immunity, neutrophils and macrophages in response to infection. A change in any of these components responsible for resistance to a particular virus may be correlated with an alteration of mortality an pathogenesis of the viral infection. Three experimental viral infections in mice that are potential candidates for use in determining immunotoxicity are discussed in terms of the response of individual components of resistance to infection and how changes in there components result in alterations of viral pathogenesis. The resistance to encephalomyocarditis virus infection in mice appears to be primarily mediated by antibody and interferon while with herpes simplex virus, infections are mainly controlled through cell-mediated immunity, macrophages, and possible interferon. Cellular immunity also appears to be primarily responsible for resistance to cytomegalovirus infections. Therefore, it is important in the use of these systems for evaluating immunotoxicity to define the pathogenesis of the viral infection and the specific host responses to these infections and to be able to correlate a change in host resistance with an alteration of the viral infection." @default.
- W2011707399 created "2016-06-24" @default.
- W2011707399 creator A5015242485 @default.
- W2011707399 date "1982-02-01" @default.
- W2011707399 modified "2023-09-30" @default.
- W2011707399 title "Use of viral infections in animal models to assess changes in the immune system." @default.
- W2011707399 cites W115132872 @default.
- W2011707399 cites W1587021235 @default.
- W2011707399 cites W1620857360 @default.
- W2011707399 cites W1960022852 @default.
- W2011707399 cites W1964172409 @default.
- W2011707399 cites W1969734402 @default.
- W2011707399 cites W1992303856 @default.
- W2011707399 cites W2020920952 @default.
- W2011707399 cites W2022604203 @default.
- W2011707399 cites W2033301012 @default.
- W2011707399 cites W2038965275 @default.
- W2011707399 cites W2072701951 @default.
- W2011707399 cites W2073960033 @default.
- W2011707399 cites W2087441250 @default.
- W2011707399 cites W2089193554 @default.
- W2011707399 cites W2107747657 @default.
- W2011707399 cites W2159539350 @default.
- W2011707399 cites W2164990448 @default.
- W2011707399 cites W2168256337 @default.
- W2011707399 cites W2313032030 @default.
- W2011707399 cites W2314281620 @default.
- W2011707399 cites W2325182701 @default.
- W2011707399 cites W2325963566 @default.
- W2011707399 cites W2327975109 @default.
- W2011707399 doi "https://doi.org/10.1289/ehp.824371" @default.
- W2011707399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1568886" @default.
- W2011707399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6174323" @default.
- W2011707399 hasPublicationYear "1982" @default.
- W2011707399 type Work @default.
- W2011707399 sameAs 2011707399 @default.
- W2011707399 citedByCount "15" @default.
- W2011707399 countsByYear W20117073992018 @default.
- W2011707399 crossrefType "journal-article" @default.
- W2011707399 hasAuthorship W2011707399A5015242485 @default.
- W2011707399 hasBestOaLocation W20117073991 @default.
- W2011707399 hasConcept C140704245 @default.
- W2011707399 hasConcept C140933497 @default.
- W2011707399 hasConcept C159047783 @default.
- W2011707399 hasConcept C159654299 @default.
- W2011707399 hasConcept C203014093 @default.
- W2011707399 hasConcept C2522874641 @default.
- W2011707399 hasConcept C2776178377 @default.
- W2011707399 hasConcept C2776409557 @default.
- W2011707399 hasConcept C2777732132 @default.
- W2011707399 hasConcept C2779341262 @default.
- W2011707399 hasConcept C2780727368 @default.
- W2011707399 hasConcept C2780942790 @default.
- W2011707399 hasConcept C2781196997 @default.
- W2011707399 hasConcept C86803240 @default.
- W2011707399 hasConcept C8891405 @default.
- W2011707399 hasConceptScore W2011707399C140704245 @default.
- W2011707399 hasConceptScore W2011707399C140933497 @default.
- W2011707399 hasConceptScore W2011707399C159047783 @default.
- W2011707399 hasConceptScore W2011707399C159654299 @default.
- W2011707399 hasConceptScore W2011707399C203014093 @default.
- W2011707399 hasConceptScore W2011707399C2522874641 @default.
- W2011707399 hasConceptScore W2011707399C2776178377 @default.
- W2011707399 hasConceptScore W2011707399C2776409557 @default.
- W2011707399 hasConceptScore W2011707399C2777732132 @default.
- W2011707399 hasConceptScore W2011707399C2779341262 @default.
- W2011707399 hasConceptScore W2011707399C2780727368 @default.
- W2011707399 hasConceptScore W2011707399C2780942790 @default.
- W2011707399 hasConceptScore W2011707399C2781196997 @default.
- W2011707399 hasConceptScore W2011707399C86803240 @default.
- W2011707399 hasConceptScore W2011707399C8891405 @default.
- W2011707399 hasLocation W20117073991 @default.
- W2011707399 hasLocation W20117073992 @default.
- W2011707399 hasLocation W20117073993 @default.
- W2011707399 hasLocation W20117073994 @default.
- W2011707399 hasOpenAccess W2011707399 @default.
- W2011707399 hasPrimaryLocation W20117073991 @default.
- W2011707399 hasRelatedWork W1561127041 @default.
- W2011707399 hasRelatedWork W1973676625 @default.
- W2011707399 hasRelatedWork W2004297244 @default.
- W2011707399 hasRelatedWork W2005460711 @default.
- W2011707399 hasRelatedWork W2066966091 @default.
- W2011707399 hasRelatedWork W2125365865 @default.
- W2011707399 hasRelatedWork W2150783001 @default.
- W2011707399 hasRelatedWork W2409733744 @default.
- W2011707399 hasRelatedWork W2487426406 @default.
- W2011707399 hasRelatedWork W4220788934 @default.
- W2011707399 hasVolume "43" @default.
- W2011707399 isParatext "false" @default.
- W2011707399 isRetracted "false" @default.
- W2011707399 magId "2011707399" @default.
- W2011707399 workType "article" @default.