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• W2011708069 abstract "Although the excitatory effects of noradrenaline have been thoroughly studied in the central nervous system, there is relatively little known about the adrenergic effects on Ca2+ dynamics of dendrites. In the present study, we imaged basal dendrites of layer 5 pyramidal neurons in the prefrontal cortex using two-photon microscopy. In our experiments noradrenaline, applied in the bath, enhanced excitability of layer 5 pyramidal neurons. The number of evoked action potentials following current injection to the soma increased by 44.7% on average. In the basal dendrites and spines the evoked Ca2+ responses were also markedly enhanced. Noradrenaline-induced effects could be blocked by the β-adrenergic blocker propranolol. Our data, that activation of the noradrenergic system increases excitability of layer 5 pyramidal neurons via β-adrenergic receptors and enhances Ca2+ signaling in basal dendrites, suggest a cellular site of action for noradrenaline to improve the integrative capabilities of dendrites." @default.
• W2011708069 created "2016-06-24" @default.
• W2011708069 creator A5047746084 @default.
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• W2011708069 date "2007-10-01" @default.
• W2011708069 modified "2023-09-26" @default.
• W2011708069 title "Noradrenergic enhancement of Ca2+ responses of basal dendrites in layer 5 pyramidal neurons of the prefrontal cortex" @default.
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• W2011708069 doi "https://doi.org/10.1016/j.neuint.2007.05.008" @default.
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