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- W2011733603 abstract "This study was designed to determine the dose linearity and proportionality of moricizine after multiple-dose administrations of 450 to 900 mg/day. The study design was an open-label, four-treatment, four-period sequentials escalating dose. Twelve subjects each received multiple doses of 150, 200, 250, and 300 mg of moricizine every 8 hours during 7 days of treatment. Blood samples for pharmacokinetic determinations were obtained on day 7 of each treatment period during an 8-hour time interval. Cmin determinations were also made on specific days of each treatment period. The AUC tau (area under the curve from time 0 to 8 hours), Cmax, and Cmin parameters were all normalized to the 250-mg (750 mg/day) dose. No statistically significant differences were seen in these parameters at the four treatment levels. It was concluded that moricizine follows first-order or linear pharmacokinetics after multiple dosing and exhibits dose proportional pharmacokinetics in the dosage-range studies. This range corresponds to the clinically useful dosage range." @default.
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- W2011733603 date "1991-03-01" @default.
- W2011733603 modified "2023-10-02" @default.
- W2011733603 title "Dose Proportionality of Moricizine After Escalating Multiple Doses in Healthy Volunteers" @default.
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- W2011733603 doi "https://doi.org/10.1002/j.1552-4604.1991.tb04966.x" @default.
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