FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011736385> ?p ?o ?g. }

• W2011736385 endingPage "310" @default.
• W2011736385 startingPage "301" @default.
• W2011736385 abstract "SUMMARY We identified three patients (two of them relatives) with RA and signs of scleroderma whose sera contained a high titre of IgG class antibodies against the nucleoli and the nucleoplasm of cells of different mammalian origins. Sera from these patients uniformly immunoprecipitated four polypeptides, from a 35S-methionine-labelled HeLa cell extract, whose mol. wts were 120, 105, 95 and 42 kD. Of these, the 95-kD protein was highly phosphorylated. By immunoblotting, these sera reacted with 105-, 95- and 42-kD proteins and affinity-purified antibodies from these, demonstrating that 105- and 95-kD proteins shared cross-reactive epitopes. Moreover, affinity-purified antibodies from each of these proteins immunoprecipitated the whole complex. Localization studies using immunoelectron microscopy and in vivo actinomycin-D-treated cells demonstrated that the 105-, 95- and 42-kD proteins were present in the granular component of the nucleolus and the nucleoplasm. In addition, the 105- and 95-kD were present in free polyribosomes as well as ribosomes attached to endoplasmic reticulum. Pulse/chase experiments strongly suggested that the complex was accomplished shortly after a 10-min pulse. It was preferentially present in the nucleus after a 2 h chase and in both nucleus and cytoplasm after a 5 h chase. We conclude that a protein complex with a main nucleolar distribution is a new autoantigen (p105-p42) recognized by autoantibodies present in the serum of a subgroup of patients with RA and scleroderma signs. These antibodies could be useful as diagnostic markers and as tools for further studies involving the biology of the nucleolus." @default.
• W2011736385 created "2016-06-24" @default.
• W2011736385 creator A5013005640 @default.
• W2011736385 creator A5030211540 @default.
• W2011736385 creator A5035473744 @default.
• W2011736385 creator A5040510351 @default.
• W2011736385 creator A5072189156 @default.
• W2011736385 creator A5079951138 @default.
• W2011736385 creator A5082166062 @default.
• W2011736385 creator A5088146108 @default.
• W2011736385 date "1998-11-01" @default.
• W2011736385 modified "2023-10-13" @default.
• W2011736385 title "Antibodies against a novel nucleolar and cytoplasmic antigen (p105-p42) present in the sera of patients with a subset of rheumatoid arthritis (RA) with signs of scleroderma" @default.
• W2011736385 cites W1520268659 @default.
• W2011736385 cites W1530113069 @default.
• W2011736385 cites W1560448233 @default.
• W2011736385 cites W1566845757 @default.
• W2011736385 cites W1576693507 @default.
• W2011736385 cites W1966439810 @default.
• W2011736385 cites W1972934227 @default.
• W2011736385 cites W1973530039 @default.
• W2011736385 cites W1976596852 @default.
• W2011736385 cites W1980542111 @default.
• W2011736385 cites W1993719557 @default.
• W2011736385 cites W1995327326 @default.
• W2011736385 cites W1995379503 @default.
• W2011736385 cites W1995452469 @default.
• W2011736385 cites W2004208265 @default.
• W2011736385 cites W2015609638 @default.
• W2011736385 cites W2016152543 @default.
• W2011736385 cites W2017455399 @default.
• W2011736385 cites W2018289835 @default.
• W2011736385 cites W2029913352 @default.
• W2011736385 cites W2045844891 @default.
• W2011736385 cites W2053255454 @default.
• W2011736385 cites W2065054003 @default.
• W2011736385 cites W2070662314 @default.
• W2011736385 cites W2071395224 @default.
• W2011736385 cites W2072076805 @default.
• W2011736385 cites W2081028616 @default.
• W2011736385 cites W2087302056 @default.
• W2011736385 cites W2099657885 @default.
• W2011736385 cites W2101108802 @default.
• W2011736385 cites W2121699107 @default.
• W2011736385 cites W2122398974 @default.
• W2011736385 cites W2123251236 @default.
• W2011736385 cites W2153542488 @default.
• W2011736385 cites W2160997099 @default.
• W2011736385 cites W2164358316 @default.
• W2011736385 cites W2171800907 @default.
• W2011736385 cites W2328389591 @default.
• W2011736385 cites W2415532012 @default.
• W2011736385 doi "https://doi.org/10.1046/j.1365-2249.1998.00725.x" @default.
• W2011736385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1905101" @default.
• W2011736385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9822291" @default.
• W2011736385 hasPublicationYear "1998" @default.
• W2011736385 type Work @default.
• W2011736385 sameAs 2011736385 @default.
• W2011736385 citedByCount "9" @default.
• W2011736385 countsByYear W20117363852018 @default.
• W2011736385 crossrefType "journal-article" @default.
• W2011736385 hasAuthorship W2011736385A5013005640 @default.
• W2011736385 hasAuthorship W2011736385A5030211540 @default.
• W2011736385 hasAuthorship W2011736385A5035473744 @default.
• W2011736385 hasAuthorship W2011736385A5040510351 @default.
• W2011736385 hasAuthorship W2011736385A5072189156 @default.
• W2011736385 hasAuthorship W2011736385A5079951138 @default.
• W2011736385 hasAuthorship W2011736385A5082166062 @default.
• W2011736385 hasAuthorship W2011736385A5088146108 @default.
• W2011736385 hasBestOaLocation W20117363851 @default.
• W2011736385 hasConcept C112952253 @default.
• W2011736385 hasConcept C147483822 @default.
• W2011736385 hasConcept C153911025 @default.
• W2011736385 hasConcept C159654299 @default.
• W2011736385 hasConcept C163764329 @default.
• W2011736385 hasConcept C183873130 @default.
• W2011736385 hasConcept C190062978 @default.
• W2011736385 hasConcept C195616568 @default.
• W2011736385 hasConcept C203014093 @default.
• W2011736385 hasConcept C2776007122 @default.
• W2011736385 hasConcept C2993140218 @default.
• W2011736385 hasConcept C71829478 @default.
• W2011736385 hasConcept C86803240 @default.
• W2011736385 hasConcept C95444343 @default.
• W2011736385 hasConceptScore W2011736385C112952253 @default.
• W2011736385 hasConceptScore W2011736385C147483822 @default.
• W2011736385 hasConceptScore W2011736385C153911025 @default.
• W2011736385 hasConceptScore W2011736385C159654299 @default.
• W2011736385 hasConceptScore W2011736385C163764329 @default.
• W2011736385 hasConceptScore W2011736385C183873130 @default.
• W2011736385 hasConceptScore W2011736385C190062978 @default.
• W2011736385 hasConceptScore W2011736385C195616568 @default.
• W2011736385 hasConceptScore W2011736385C203014093 @default.
• W2011736385 hasConceptScore W2011736385C2776007122 @default.
• W2011736385 hasConceptScore W2011736385C2993140218 @default.
• W2011736385 hasConceptScore W2011736385C71829478 @default.
• W2011736385 hasConceptScore W2011736385C86803240 @default.
• W2011736385 hasConceptScore W2011736385C95444343 @default.

• next