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- W201173826 abstract "This chapter discusses the role of phospholipids in hormone activation of adenylate cyclase. It describes the characteristics of the solubilized enzyme, the role of phospholipids in the hormonal responsiveness of adenylate cyclase, and the relationship of hormone binding to activation of the enzyme. Adenylate cyclase is a membrane-bound enzyme that occupies a central role in mediating the effects of a number of hormones on their target tissues. It has been found that phospholipids play critical roles in hormonal activation of adenylate cyclase systems. The membrane-bound adenylate cyclase is activated by the catecholamines, glucagon, histamine, and thyroxine and triiodothyronine. Solubilization abolished hormone responsiveness. However, fluoride activation, which is thought to result from a direct interaction with the catalytic site, is unimpaired. The addition of pure phosphatidylserine restores the activation of adenylate cyclase by glucagon and histamine but not norepinephrine. In the presence of phosphatidylserine, glucagon and histamine activate the enzyme over a concentration range that is identical to that observed with the membrane-bound enzyme." @default.
- W201173826 created "2016-06-24" @default.
- W201173826 creator A5053996973 @default.
- W201173826 date "1973-01-01" @default.
- W201173826 modified "2023-09-25" @default.
- W201173826 title "The Role of Phospholipids in Hormone Activation of Adenylate Cyclase" @default.
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- W201173826 doi "https://doi.org/10.1016/b978-0-12-571129-6.50013-0" @default.
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