Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011746474> ?p ?o ?g. }
- W2011746474 endingPage "407" @default.
- W2011746474 startingPage "401" @default.
- W2011746474 abstract "This study aims to reveal the morphological, histological, and immunohistochemical mechanism of pannus formation using resected pannus tissue from patients with prosthetic valve dysfunction.Eleven patients with prosthetic valve (St Jude Medical valve) dysfunction in the aortic position who underwent reoperation were studied. We used specimens of resected pannus for histological staining (hematoxylin and eosin, Grocott's, azan, elastica van Gieson) and immunohistochemical staining (transforming growth factor-beta, transforming growth factor-beta receptor 1, alpha-smooth muscle actin, desmin, epithelial membrane antigen, CD34, factor VIII, CD68KP1, matrix metalloproteinase-1, matrix metalloproteinase-3, and matrix metalloproteinase-9).Pannus without thrombus was observed at the periannulus of the left ventricular septal side; it extended into the pivot guard, interfering with the movement of the straight edge of the leaflet. The histological staining demonstrated that the specimens were mainly constituted with collagen and elastic fibrous tissue accompanied by endothelial cells, chronic inflammatory cells infiltration, and myofibroblasts. The immunohistochemical findings showed significant expression of transforming growth factor-beta, transforming growth factor-beta receptor 1, CD34, and factor VIII in the endothelial cells of the lumen layer; strong transforming growth factor-beta receptor 1, alpha-smooth muscle actin, desmin, and epithelial membrane antigen in the myofibroblasts of the media layer; and transforming growth factor-beta, transforming growth factor-beta receptor 1, and CD68KP1 in macrophages of the stump lesion.Pannus appeared to originate in the neointima in the periannulus of the left ventricular septum. The structure of the pannus consisted of myofibroblasts and an extracellular matrix such as collagen fiber. The pannus formation after prosthetic valve replacement may be associated with a process of periannular tissue healing via the expression of transforming growth factor-beta." @default.
- W2011746474 created "2016-06-24" @default.
- W2011746474 creator A5010610480 @default.
- W2011746474 creator A5021957719 @default.
- W2011746474 creator A5039298057 @default.
- W2011746474 creator A5050127370 @default.
- W2011746474 creator A5055757859 @default.
- W2011746474 creator A5062304823 @default.
- W2011746474 creator A5070475291 @default.
- W2011746474 creator A5081440874 @default.
- W2011746474 creator A5090026797 @default.
- W2011746474 date "2003-08-01" @default.
- W2011746474 modified "2023-09-25" @default.
- W2011746474 title "Obstruction of st jude medical valves in the aortic position: histology and immunohistochemistry of pannus" @default.
- W2011746474 cites W196081891 @default.
- W2011746474 cites W1963641595 @default.
- W2011746474 cites W1965092464 @default.
- W2011746474 cites W1977448440 @default.
- W2011746474 cites W1979978633 @default.
- W2011746474 cites W1995708332 @default.
- W2011746474 cites W2003513543 @default.
- W2011746474 cites W2004161688 @default.
- W2011746474 cites W2005280349 @default.
- W2011746474 cites W2007914335 @default.
- W2011746474 cites W2020903685 @default.
- W2011746474 cites W2039010543 @default.
- W2011746474 cites W2049971464 @default.
- W2011746474 cites W2063599136 @default.
- W2011746474 cites W2074091940 @default.
- W2011746474 cites W2080860127 @default.
- W2011746474 cites W2085746981 @default.
- W2011746474 cites W2087817784 @default.
- W2011746474 cites W2090387609 @default.
- W2011746474 cites W2115242154 @default.
- W2011746474 cites W2120927716 @default.
- W2011746474 cites W2129963242 @default.
- W2011746474 cites W2134524472 @default.
- W2011746474 cites W2157323410 @default.
- W2011746474 cites W2158862405 @default.
- W2011746474 cites W2162589134 @default.
- W2011746474 cites W2165000537 @default.
- W2011746474 doi "https://doi.org/10.1016/s0022-5223(03)00702-5" @default.
- W2011746474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12928636" @default.
- W2011746474 hasPublicationYear "2003" @default.
- W2011746474 type Work @default.
- W2011746474 sameAs 2011746474 @default.
- W2011746474 citedByCount "91" @default.
- W2011746474 countsByYear W20117464742012 @default.
- W2011746474 countsByYear W20117464742013 @default.
- W2011746474 countsByYear W20117464742014 @default.
- W2011746474 countsByYear W20117464742015 @default.
- W2011746474 countsByYear W20117464742016 @default.
- W2011746474 countsByYear W20117464742017 @default.
- W2011746474 countsByYear W20117464742018 @default.
- W2011746474 countsByYear W20117464742019 @default.
- W2011746474 countsByYear W20117464742020 @default.
- W2011746474 countsByYear W20117464742021 @default.
- W2011746474 countsByYear W20117464742022 @default.
- W2011746474 countsByYear W20117464742023 @default.
- W2011746474 crossrefType "journal-article" @default.
- W2011746474 hasAuthorship W2011746474A5010610480 @default.
- W2011746474 hasAuthorship W2011746474A5021957719 @default.
- W2011746474 hasAuthorship W2011746474A5039298057 @default.
- W2011746474 hasAuthorship W2011746474A5050127370 @default.
- W2011746474 hasAuthorship W2011746474A5055757859 @default.
- W2011746474 hasAuthorship W2011746474A5062304823 @default.
- W2011746474 hasAuthorship W2011746474A5070475291 @default.
- W2011746474 hasAuthorship W2011746474A5081440874 @default.
- W2011746474 hasAuthorship W2011746474A5090026797 @default.
- W2011746474 hasBestOaLocation W20117464741 @default.
- W2011746474 hasConcept C126322002 @default.
- W2011746474 hasConcept C142724271 @default.
- W2011746474 hasConcept C2777077863 @default.
- W2011746474 hasConcept C2777339539 @default.
- W2011746474 hasConcept C2777746085 @default.
- W2011746474 hasConcept C2778283817 @default.
- W2011746474 hasConcept C2778583881 @default.
- W2011746474 hasConcept C71924100 @default.
- W2011746474 hasConceptScore W2011746474C126322002 @default.
- W2011746474 hasConceptScore W2011746474C142724271 @default.
- W2011746474 hasConceptScore W2011746474C2777077863 @default.
- W2011746474 hasConceptScore W2011746474C2777339539 @default.
- W2011746474 hasConceptScore W2011746474C2777746085 @default.
- W2011746474 hasConceptScore W2011746474C2778283817 @default.
- W2011746474 hasConceptScore W2011746474C2778583881 @default.
- W2011746474 hasConceptScore W2011746474C71924100 @default.
- W2011746474 hasIssue "2" @default.
- W2011746474 hasLocation W20117464741 @default.
- W2011746474 hasLocation W20117464742 @default.
- W2011746474 hasOpenAccess W2011746474 @default.
- W2011746474 hasPrimaryLocation W20117464741 @default.
- W2011746474 hasRelatedWork W2000741479 @default.
- W2011746474 hasRelatedWork W2011746474 @default.
- W2011746474 hasRelatedWork W2027087953 @default.
- W2011746474 hasRelatedWork W2409720449 @default.
- W2011746474 hasRelatedWork W2748952813 @default.
- W2011746474 hasRelatedWork W2899084033 @default.
- W2011746474 hasRelatedWork W3011073888 @default.