FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011748629> ?p ?o ?g. }

• W2011748629 endingPage "495" @default.
• W2011748629 startingPage "487" @default.
• W2011748629 abstract "Chemokines, scavenger receptors and adhesion molecules have long been known as important players in the pathogenesis of atherosclerosis. A series of studies conducted in the past few years described CXCL16/SR-PSOX--a new molecule combining those three functions, and suggested that CXCL16/SR-PSOX can be a potential player in atherogenesis. Initial ex vivo studies showed that CXCL16/SR-PSOX is abundant in human and murine atherosclerotic lesions. Following in vitro studies suggested that as an adhesion molecule CXCL16/SR-PSOX might mediate T-cell adhesion to the endothelium, as a chemokine - drive T-cell migration, stimulate cell proliferation and elicit inflammatory phenotype in smooth muscle cells (SMC) and, finally, as a scavenger receptor - mediate uptake of atherogenic lipoproteins by macrophages and SMC. All these effects are known to be pro-atherogenic. Surprisingly, in vivo studies performed in murine models of atherosclerosis suggested that CXCL16/SR-PSOX is atheroprotective, while its receptor CXCR6 is harmful. In addition, studies investigating the association of circulating CXCL16/SR-PSOX plasma concentrations with the presence and extent of coronary artery disease (CAD) in humans are controversial suggesting both positive, negative and no association. To finally answer the question whether CXCL16/SR-PSOX can serve as a causative factor, biomarker or even a therapeutic target in atherosclerosis, we are currently in need of carefully designed animal and human studies investigating the effects of CXCL16/SR-PSOX and CXCR6 deficiency, inhibition and over-expression on the progression of atherosclerosis. Such complex approach will help us unravel the mystery of CXCL16/SR-PSOX in atherosclerosis and hopefully develop better ways of treating atherosclerosis by targeting this interesting molecule." @default.
• W2011748629 created "2016-06-24" @default.
• W2011748629 creator A5026882692 @default.
• W2011748629 creator A5087150421 @default.
• W2011748629 date "2008-04-01" @default.
• W2011748629 modified "2023-10-06" @default.
• W2011748629 title "CXCL16/SR-PSOX—A friend or a foe in atherosclerosis?" @default.
• W2011748629 cites W1483984181 @default.
• W2011748629 cites W1493344427 @default.
• W2011748629 cites W1502617035 @default.
• W2011748629 cites W1561042888 @default.
• W2011748629 cites W1582669894 @default.
• W2011748629 cites W1645503476 @default.
• W2011748629 cites W1680083592 @default.
• W2011748629 cites W1875741133 @default.
• W2011748629 cites W1965058145 @default.
• W2011748629 cites W1974252625 @default.
• W2011748629 cites W1978228632 @default.
• W2011748629 cites W1989284247 @default.
• W2011748629 cites W1998240747 @default.
• W2011748629 cites W2003289473 @default.
• W2011748629 cites W2011009843 @default.
• W2011748629 cites W2027521196 @default.
• W2011748629 cites W2031397753 @default.
• W2011748629 cites W2032974245 @default.
• W2011748629 cites W2034301871 @default.
• W2011748629 cites W2043456569 @default.
• W2011748629 cites W2044024385 @default.
• W2011748629 cites W2045485422 @default.
• W2011748629 cites W2049401036 @default.
• W2011748629 cites W2052493267 @default.
• W2011748629 cites W2053874575 @default.
• W2011748629 cites W2053894585 @default.
• W2011748629 cites W2068741629 @default.
• W2011748629 cites W2072233164 @default.
• W2011748629 cites W2078066736 @default.
• W2011748629 cites W2079406352 @default.
• W2011748629 cites W2081141913 @default.
• W2011748629 cites W2082341807 @default.
• W2011748629 cites W2083994913 @default.
• W2011748629 cites W2091173515 @default.
• W2011748629 cites W2092834104 @default.
• W2011748629 cites W2093979977 @default.
• W2011748629 cites W2095715637 @default.
• W2011748629 cites W2105173724 @default.
• W2011748629 cites W2106246085 @default.
• W2011748629 cites W2109111384 @default.
• W2011748629 cites W2109631033 @default.
• W2011748629 cites W2109681394 @default.
• W2011748629 cites W2113903712 @default.
• W2011748629 cites W2114259322 @default.
• W2011748629 cites W2115017173 @default.
• W2011748629 cites W2115808255 @default.
• W2011748629 cites W2121261124 @default.
• W2011748629 cites W2123832762 @default.
• W2011748629 cites W2128471953 @default.
• W2011748629 cites W2134066661 @default.
• W2011748629 cites W2134339596 @default.
• W2011748629 cites W2137135641 @default.
• W2011748629 cites W2142808883 @default.
• W2011748629 cites W2150851411 @default.
• W2011748629 cites W2161532746 @default.
• W2011748629 cites W2163718454 @default.
• W2011748629 cites W2166083817 @default.
• W2011748629 cites W2171831396 @default.
• W2011748629 cites W2180620807 @default.
• W2011748629 cites W2310349904 @default.
• W2011748629 cites W4244632717 @default.
• W2011748629 doi "https://doi.org/10.1016/j.atherosclerosis.2007.11.034" @default.
• W2011748629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18191863" @default.
• W2011748629 hasPublicationYear "2008" @default.
• W2011748629 type Work @default.
• W2011748629 sameAs 2011748629 @default.
• W2011748629 citedByCount "71" @default.
• W2011748629 countsByYear W20117486292012 @default.
• W2011748629 countsByYear W20117486292013 @default.
• W2011748629 countsByYear W20117486292014 @default.
• W2011748629 countsByYear W20117486292015 @default.
• W2011748629 countsByYear W20117486292016 @default.
• W2011748629 countsByYear W20117486292017 @default.
• W2011748629 countsByYear W20117486292018 @default.
• W2011748629 countsByYear W20117486292019 @default.
• W2011748629 countsByYear W20117486292020 @default.
• W2011748629 countsByYear W20117486292021 @default.
• W2011748629 countsByYear W20117486292022 @default.
• W2011748629 countsByYear W20117486292023 @default.
• W2011748629 crossrefType "journal-article" @default.
• W2011748629 hasAuthorship W2011748629A5026882692 @default.
• W2011748629 hasAuthorship W2011748629A5087150421 @default.
• W2011748629 hasConcept C12823836 @default.
• W2011748629 hasConcept C13373296 @default.
• W2011748629 hasConcept C134018914 @default.
• W2011748629 hasConcept C135576274 @default.
• W2011748629 hasConcept C16224149 @default.
• W2011748629 hasConcept C170493617 @default.
• W2011748629 hasConcept C202751555 @default.
• W2011748629 hasConcept C203014093 @default.
• W2011748629 hasConcept C2776914184 @default.

• next