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• W2011750204 abstract "As a continuation of a previous controlled trial using high-dose metronidazole as a specific sensitizer of hypoxic cells, we used a more efficient nitroimidazole derivative (misonidazole, MISO) in combination with higher doses of radiation in patients with supratentorial high-grade astrocytomas. Sixty-six patients were stratified according to functional level and histological grading, and randomly allocated within 2 weeks of operation of 1 of 3 therapeutic groups: 1, conventional radiation alone, 2, large fractions of radiation with high-dose metronidazole, and 3, radiation as in Group 2 but with equitoxic doses of MISO. We examined survival as the principal end-point of the study. Neither by increasing the dose of radiation over the previous study, nor by using a more efficient sensitizer, were we able to improve survival over the current conventional daily fractionated radiation." @default.
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• W2011750204 date "1982-07-01" @default.
• W2011750204 modified "2023-10-14" @default.
• W2011750204 title "Radiation and nitroimidazoles in supratentorial high grade gliomas: a second clinical trial" @default.
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• W2011750204 doi "https://doi.org/10.1038/bjc.1982.171" @default.
• W2011750204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2011055" @default.
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