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• W2011750455 abstract "Summary Recently there has been increasing evidence to suggest that membrane translocating peptides enter cells by a receptor‐dependent pathway. There have been some studies on the mechanism of major histocompatibility complex (MHC) class I presentation of membrane translocating peptides incorporating cytotoxic T lymphocyte epitopes. However, these have been on different cell lines and only a limited number of inhibitors of the antigen presentation pathway were used. Herein, we demonstrate a comprehensive study utilizing a full spectrum of inhibitors to various pathways of MHC class I to elucidate the mechanism of the membrane translocating peptide, penetratin from Antennapedia (Int). It is clear that Int, RQIKIWFQNRRMKWKK when tandemly linked to a cytotoxic T lymphocyte peptide of ovalbumin, SIINFEKL (IntSIIN) is endocytosed via phagocytosis or macropinocytosis by dendritic cells in an ATP‐dependent manner and is processed by a proteasome‐ and tapasin‐independent pathway for presentation and loading to MHC class I molecules. In addition, the majority of antigen is taken up by negatively charged receptors. IntSIIN activates T cells in vitro and in vivo and protects mice against challenge with an ovalbumin‐expressing tumour." @default.
• W2011750455 created "2016-06-24" @default.
• W2011750455 creator A5016418767 @default.
• W2011750455 creator A5028909942 @default.
• W2011750455 creator A5051380014 @default.
• W2011750455 date "2006-02-13" @default.
• W2011750455 modified "2023-10-15" @default.
• W2011750455 title "Penetratin tandemly linked to a CTL peptide induces anti-tumour T-cell responses via a cross-presentation pathway" @default.
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• W2011750455 doi "https://doi.org/10.1111/j.1365-2567.2005.02304.x" @default.
• W2011750455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1782229" @default.
• W2011750455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16476052" @default.
• W2011750455 hasPublicationYear "2006" @default.
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