Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011750512> ?p ?o ?g. }
- W2011750512 endingPage "177" @default.
- W2011750512 startingPage "164" @default.
- W2011750512 abstract "The Tec family kinase, Itk (interleukin-2 tyrosine kinase), undergoes an in cis autophosphorylation on Y180 within its Src homology 3 (SH3) domain. Autophosphorylation of the Itk SH3 domain by the Itk kinase domain is strictly dependent on the presence of the intervening Src homology 2 (SH2) domain. A direct docking interaction between the Itk kinase and SH2 domains brings the Itk SH3 domain into the active site where Y180 is then phosphorylated. We now identify the residues on the surface of the Itk SH2 domain responsible for substrate docking and show that this SH2 surface mediates autophosphorylation in the full-length Itk molecule. The canonical phospholigand binding site on the SH2 domain is not involved in substrate docking, instead the docking site consists of side chains from three loop regions (AB, EF and BG) and part of the βD strand. These results are extended into Btk (Bruton's tyrosine kinase), a Tec family kinase linked to the B-cell deficiency X-linked agammaglobulinemia (XLA). Our results suggest that some XLA-causing mutations might impair Btk phosphorylation." @default.
- W2011750512 created "2016-06-24" @default.
- W2011750512 creator A5017104571 @default.
- W2011750512 creator A5047446510 @default.
- W2011750512 creator A5062603199 @default.
- W2011750512 creator A5070520368 @default.
- W2011750512 creator A5079911554 @default.
- W2011750512 date "2009-08-01" @default.
- W2011750512 modified "2023-09-25" @default.
- W2011750512 title "SH2-Dependent Autophosphorylation within the Tec Family Kinase Itk" @default.
- W2011750512 cites W1519847403 @default.
- W2011750512 cites W1552162740 @default.
- W2011750512 cites W1569214216 @default.
- W2011750512 cites W1893679786 @default.
- W2011750512 cites W1967796318 @default.
- W2011750512 cites W1968204784 @default.
- W2011750512 cites W1975091728 @default.
- W2011750512 cites W1976578056 @default.
- W2011750512 cites W1978329718 @default.
- W2011750512 cites W1980339285 @default.
- W2011750512 cites W1980834655 @default.
- W2011750512 cites W1981772486 @default.
- W2011750512 cites W1986322598 @default.
- W2011750512 cites W1986366957 @default.
- W2011750512 cites W2004282662 @default.
- W2011750512 cites W2015422987 @default.
- W2011750512 cites W2016742702 @default.
- W2011750512 cites W2018344755 @default.
- W2011750512 cites W2022636592 @default.
- W2011750512 cites W2030384605 @default.
- W2011750512 cites W2030649659 @default.
- W2011750512 cites W2033036465 @default.
- W2011750512 cites W2034140083 @default.
- W2011750512 cites W2035277099 @default.
- W2011750512 cites W2035863328 @default.
- W2011750512 cites W2038452432 @default.
- W2011750512 cites W2043363499 @default.
- W2011750512 cites W2043794217 @default.
- W2011750512 cites W2047301656 @default.
- W2011750512 cites W2051810870 @default.
- W2011750512 cites W2060829665 @default.
- W2011750512 cites W2063586295 @default.
- W2011750512 cites W2066541818 @default.
- W2011750512 cites W2077518158 @default.
- W2011750512 cites W2085193833 @default.
- W2011750512 cites W2086878398 @default.
- W2011750512 cites W2088274907 @default.
- W2011750512 cites W2091960651 @default.
- W2011750512 cites W2094745870 @default.
- W2011750512 cites W2097532486 @default.
- W2011750512 cites W2104807989 @default.
- W2011750512 cites W2114449882 @default.
- W2011750512 cites W2143521765 @default.
- W2011750512 cites W2144598572 @default.
- W2011750512 cites W2149952120 @default.
- W2011750512 cites W2162823344 @default.
- W2011750512 cites W2166693967 @default.
- W2011750512 cites W248588628 @default.
- W2011750512 cites W4242200123 @default.
- W2011750512 doi "https://doi.org/10.1016/j.jmb.2009.06.023" @default.
- W2011750512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2722949" @default.
- W2011750512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19523959" @default.
- W2011750512 hasPublicationYear "2009" @default.
- W2011750512 type Work @default.
- W2011750512 sameAs 2011750512 @default.
- W2011750512 citedByCount "18" @default.
- W2011750512 countsByYear W20117505122012 @default.
- W2011750512 countsByYear W20117505122013 @default.
- W2011750512 countsByYear W20117505122018 @default.
- W2011750512 countsByYear W20117505122019 @default.
- W2011750512 countsByYear W20117505122020 @default.
- W2011750512 countsByYear W20117505122022 @default.
- W2011750512 crossrefType "journal-article" @default.
- W2011750512 hasAuthorship W2011750512A5017104571 @default.
- W2011750512 hasAuthorship W2011750512A5047446510 @default.
- W2011750512 hasAuthorship W2011750512A5062603199 @default.
- W2011750512 hasAuthorship W2011750512A5070520368 @default.
- W2011750512 hasAuthorship W2011750512A5079911554 @default.
- W2011750512 hasBestOaLocation W20117505122 @default.
- W2011750512 hasConcept C104317684 @default.
- W2011750512 hasConcept C108636557 @default.
- W2011750512 hasConcept C143065580 @default.
- W2011750512 hasConcept C150109051 @default.
- W2011750512 hasConcept C159110408 @default.
- W2011750512 hasConcept C184235292 @default.
- W2011750512 hasConcept C185592680 @default.
- W2011750512 hasConcept C196347352 @default.
- W2011750512 hasConcept C197153747 @default.
- W2011750512 hasConcept C2779976819 @default.
- W2011750512 hasConcept C32619005 @default.
- W2011750512 hasConcept C41685203 @default.
- W2011750512 hasConcept C42362537 @default.
- W2011750512 hasConcept C55493867 @default.
- W2011750512 hasConcept C62478195 @default.
- W2011750512 hasConcept C71924100 @default.
- W2011750512 hasConcept C86803240 @default.
- W2011750512 hasConcept C90059517 @default.
- W2011750512 hasConcept C95444343 @default.