FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011762466> ?p ?o ?g. }

• W2011762466 endingPage "340" @default.
• W2011762466 startingPage "328" @default.
• W2011762466 abstract "Epsilon-polylysine is a homopolymer of L-lysine, containing approximately 30 L-lysine subunits, as synthesized in aerobic bacterial fermentation by Streptomyces albulus. epsilon -Polylysine is approved for food use in Japan as an antimicrobial preservative. A series of pharmacokinetic and metabolic profile studies on epsilon -polylysine have been conducted in rats in order to provide a better understanding of the reason for its lack of toxicological effects in subchronic and chronic feeding bioassays using relatively high concentrations in the diet up to 50000 ppm. As reported in this article, epsilon -polylysine was practically non-toxic in an acute oral toxicity study in rats, with no mortality up to 5 g/kg and was not mutagenic in bacterial reversion assays. Absorption, distribution, metabolism and excretion (ADME) studies on 14C-radiolabeled epsilon -polylysine, given in a single dose to fasted male rats at 100mg/kg, revealed low absorption from the gastrointestinal tract. All but trace amounts of the dosed radioactivity was eliminated by excretion within 168 h and over 97% was accounted for in urine (1.2%), feces (92.9%), or expired air (3%) by 48 h. The sum of the cumulative excretion with routes associated with absorption in urine, expired air and carcass was 6.4% of total recovered radioactivity; approximately 94% of the dose of epsilon -polylysine passed unabsorbed through the gastrointestinal tract in the feces. Whole body autoradiography did not show concentration of absorbed epsilon -polylysine in any tissue or organ. Excretion half-lives of epsilon -polylysine equivalents in blood and plasma were 20 and 3.9 days, likely prolonged by the incorporation into protein of cleaved L-lysine. Metabolic profiles by HPLC analysis of plasma samples suggest that L-lysine is the predominant early metabolic by-product, likely from protease activity in the upper GI tract; only 0.2% of the administered parent compound was found in plasma. At 8-72 h, HPLC profiles show diminishing levels of epsilon -polylysine and L-lysine in plasma, accompanied by a shift to larger peaks of homopolymer fragments of varying subunit length, presumably from microbial degradation of epsilon -polylysine in the lower gut. HPLC profiles of urine and feces collected from 0 to 24 h post-dosing revealed three distinct peaks in urine, the first peak likely to be epsilon -polylysine and epsilon -polylysine less a few amino acid subunits, and the second, L-lysine and the third, a metabolite of L-lysine. Radiolabeled L-lysine was reduced from 67.2% of the radioactivity in plasma at 30 min to 7.5% at 4 h, indicating that L-lysine is readily removed from plasma from essential amino acid incorporation into protein. Based on the findings of the ADME studies and lack of toxicity in safety studies, the proposed use of epsilon -polylysine as a preservative in foods is considered to be safe." @default.
• W2011762466 created "2016-06-24" @default.
• W2011762466 creator A5005096815 @default.
• W2011762466 creator A5010096669 @default.
• W2011762466 creator A5018973733 @default.
• W2011762466 creator A5024999428 @default.
• W2011762466 creator A5025897225 @default.
• W2011762466 creator A5041318347 @default.
• W2011762466 creator A5049755217 @default.
• W2011762466 creator A5077186384 @default.
• W2011762466 creator A5080269100 @default.
• W2011762466 date "2003-04-01" @default.
• W2011762466 modified "2023-10-01" @default.
• W2011762466 title "Use of ADME studies to confirm the safety of ε-polylysine as a preservative in food" @default.
• W2011762466 cites W2022889199 @default.
• W2011762466 cites W2025433707 @default.
• W2011762466 cites W2034193502 @default.
• W2011762466 doi "https://doi.org/10.1016/s0273-2300(03)00029-1" @default.
• W2011762466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12726761" @default.
• W2011762466 hasPublicationYear "2003" @default.
• W2011762466 type Work @default.
• W2011762466 sameAs 2011762466 @default.
• W2011762466 citedByCount "252" @default.
• W2011762466 countsByYear W20117624662012 @default.
• W2011762466 countsByYear W20117624662013 @default.
• W2011762466 countsByYear W20117624662014 @default.
• W2011762466 countsByYear W20117624662015 @default.
• W2011762466 countsByYear W20117624662016 @default.
• W2011762466 countsByYear W20117624662017 @default.
• W2011762466 countsByYear W20117624662018 @default.
• W2011762466 countsByYear W20117624662019 @default.
• W2011762466 countsByYear W20117624662020 @default.
• W2011762466 countsByYear W20117624662021 @default.
• W2011762466 countsByYear W20117624662022 @default.
• W2011762466 countsByYear W20117624662023 @default.
• W2011762466 crossrefType "journal-article" @default.
• W2011762466 hasAuthorship W2011762466A5005096815 @default.
• W2011762466 hasAuthorship W2011762466A5010096669 @default.
• W2011762466 hasAuthorship W2011762466A5018973733 @default.
• W2011762466 hasAuthorship W2011762466A5024999428 @default.
• W2011762466 hasAuthorship W2011762466A5025897225 @default.
• W2011762466 hasAuthorship W2011762466A5041318347 @default.
• W2011762466 hasAuthorship W2011762466A5049755217 @default.
• W2011762466 hasAuthorship W2011762466A5077186384 @default.
• W2011762466 hasAuthorship W2011762466A5080269100 @default.
• W2011762466 hasConcept C10146269 @default.
• W2011762466 hasConcept C112705442 @default.
• W2011762466 hasConcept C121332964 @default.
• W2011762466 hasConcept C125287762 @default.
• W2011762466 hasConcept C178790620 @default.
• W2011762466 hasConcept C185592680 @default.
• W2011762466 hasConcept C195289149 @default.
• W2011762466 hasConcept C24890656 @default.
• W2011762466 hasConcept C2777056448 @default.
• W2011762466 hasConcept C2780026642 @default.
• W2011762466 hasConcept C2780075363 @default.
• W2011762466 hasConcept C2780512811 @default.
• W2011762466 hasConcept C29730261 @default.
• W2011762466 hasConcept C31903555 @default.
• W2011762466 hasConcept C55493867 @default.
• W2011762466 hasConcept C61716771 @default.
• W2011762466 hasConcept C62231903 @default.
• W2011762466 hasConcept C67031304 @default.
• W2011762466 hasConcept C69366308 @default.
• W2011762466 hasConcept C86803240 @default.
• W2011762466 hasConcept C89423630 @default.
• W2011762466 hasConcept C98274493 @default.
• W2011762466 hasConceptScore W2011762466C10146269 @default.
• W2011762466 hasConceptScore W2011762466C112705442 @default.
• W2011762466 hasConceptScore W2011762466C121332964 @default.
• W2011762466 hasConceptScore W2011762466C125287762 @default.
• W2011762466 hasConceptScore W2011762466C178790620 @default.
• W2011762466 hasConceptScore W2011762466C185592680 @default.
• W2011762466 hasConceptScore W2011762466C195289149 @default.
• W2011762466 hasConceptScore W2011762466C24890656 @default.
• W2011762466 hasConceptScore W2011762466C2777056448 @default.
• W2011762466 hasConceptScore W2011762466C2780026642 @default.
• W2011762466 hasConceptScore W2011762466C2780075363 @default.
• W2011762466 hasConceptScore W2011762466C2780512811 @default.
• W2011762466 hasConceptScore W2011762466C29730261 @default.
• W2011762466 hasConceptScore W2011762466C31903555 @default.
• W2011762466 hasConceptScore W2011762466C55493867 @default.
• W2011762466 hasConceptScore W2011762466C61716771 @default.
• W2011762466 hasConceptScore W2011762466C62231903 @default.
• W2011762466 hasConceptScore W2011762466C67031304 @default.
• W2011762466 hasConceptScore W2011762466C69366308 @default.
• W2011762466 hasConceptScore W2011762466C86803240 @default.
• W2011762466 hasConceptScore W2011762466C89423630 @default.
• W2011762466 hasConceptScore W2011762466C98274493 @default.
• W2011762466 hasIssue "2" @default.
• W2011762466 hasLocation W20117624661 @default.
• W2011762466 hasLocation W20117624662 @default.
• W2011762466 hasOpenAccess W2011762466 @default.
• W2011762466 hasPrimaryLocation W20117624661 @default.
• W2011762466 hasRelatedWork W1925982542 @default.
• W2011762466 hasRelatedWork W1993300568 @default.
• W2011762466 hasRelatedWork W2009246547 @default.
• W2011762466 hasRelatedWork W2017389175 @default.

• next