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• W2011769730 abstract "952 Background/aims: The results of liver transplantation (LT) are usually expressed as life expectancy after transplantation. These results are overestimated since they do not take into account the mortality of patients while waiting for a graft. The aims of this study were to analyse the results of transplantation from the time it has been decided and to determine predictive factors of mortality on the waiting list. Patients: From 1990 to 1998, 200 consecutive cirrhotic patients without hepatocellular carcinoma (117 males and 83 females) have been put on the waiting list for LT. Mean age was 44±10 years. The cause of cirrhosis was alcohol, HBV infection, HCV infection, biliary disease (primary biliary cirrhosis or primary sclerosing cholangitis) and miscellaneous diseases in 26%, 15%, 20%, 22% and 17%, repectively. Results: The probability of death on the waiting list was 20%, 21%, 11%, 6% and 19% for alcoholic, HBV-related, HCV-related, biliary and miscellaneous cirrhosis, respectively. Mean time interval from inscription on the waiting list to transplantation was 4.5±5 months. Mean time interval from inscription to death in patients who died before transplantation was 2.1±1.9 months. Multivariate analysis showed that the factors independently associated with the probability of death before transplantation were alcoholic or HBV-related origin of cirrhosis (p=0.03 and 0.003, respectively), female sex (p=0.01), refractory ascites (p=0.01), bilirubin (p=0.003) and creatinine (p=0.0001). Taking into account the mortality of patients on the waiting list, 3-year survival after inscritpion on the waiting list was 58%, 64%, 66%, 62% and 62% for alcoholic, HBV-related HCV-related, biliary and miscellaneous cirrhosis, respectively (as compared with 67%, 83%, 72% 67% and 75% after transplantation, respectively). Conclusions: The results observed in this series show that the global results of LT are markedly influenced by the mortality on the waiting list which represents up to about 50% of overall mortality. Apart from the severity of cirrhosis at the time patients are put on the waiting list, the risk of death before transplantation seems to be increased for alcoholic or HBV-related cirrhosis as compared with cirrhosis of other causes. Whatever the etiology of cirrhosis, female sex, presence of refractory ascites, high serum blirubin and creatinine levels seem to increase significantly the risk of death before transplantation. Patients with one or several of these risk factors may be put on the waiting list at an earlier stage." @default.
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• W2011769730 date "1999-04-01" @default.
• W2011769730 modified "2023-10-01" @default.
• W2011769730 title "PREDICTIVE FACTORS OF MORTALITY IN CIRRHOTIC PATIENTS WHO ARE WAITING FOR LIVER TRANSPLANTATION: RESULTS OF A PROSPECTIVE STUDY IN 200 PATIENTS" @default.
• W2011769730 doi "https://doi.org/10.1097/00007890-199904150-00976" @default.
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