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- W2011772795 abstract "An in vitro model for neural trauma was characterized and validated. The model is based on a novel device that is capable of applying high strain rate, homogeneous, and equibiaxial deformation to neural cells in culture. The deformation waveform is fully arbitrary and controlled via closed-loop feedback. Intracellular calcium [Ca2+]i alterations were recorded in real time throughout the imposed strain with an epifluorescent microscopy system. Peak change in [Ca2+]i, recovery of [Ca2+]i, and percent responding NG108-15 cells were shown to be dependent on strain rate (1−1 to 10−1) and magnitude (0.1 to 0.3 Green’s Strain). These measures were also shown to depend significantly on the interaction between strain rate and magnitude. This model for neural trauma is a robust system that can be used to investigate the cellular tolerance and response to traumatic brain injury." @default.
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- W2011772795 date "2001-01-11" @default.
- W2011772795 modified "2023-09-27" @default.
- W2011772795 title "An in Vitro Model of Neural Trauma: Device Characterization and Calcium Response to Mechanical Stretch" @default.
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- W2011772795 doi "https://doi.org/10.1115/1.1374201" @default.
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