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- W2011786084 abstract "PURPOSE: Advancing age is associated with accumulated oxidative damage to proteins, lipids and mitochondria. In this study we tested the hypothesis that swimming exercise training could revert the age dependent oxidative damages in liver. METHODS: Young (3 months) and old (12 months) Sprague-Dawley rats were divided into four groups; young control (n=5), young exercise (n=5), old control (n=5) and old exercise (n=5). 90 minutes of swimming exercise was given to the exercise group for a period of two weeks. RESULTS: The estimated antioxidant enzyme activities including, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were decreased with age and significantly (p<0.05) increased with exercise training. However, elevated protein carbonyls and MDA levels were noticed in old animals, which indicate that old liver had greater accumulated oxidative damages. The significant drop in protein carbonyl content and increase in mitochondrial succinate dehydrogenase (SDH) activity was observed with response to swim training in old rats. CONCLUSIONS: This data implied that swim exercise training could revert the oxidative damages in liver. This was also proven by enhanced antioxidant enzyme status with response to exercise training in old rats. From these results it is cleared that age induced detrimental effects to the liver might be reversed by regular swimming exercise training in old rats." @default.
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- W2011786084 date "2009-05-01" @default.
- W2011786084 modified "2023-09-26" @default.
- W2011786084 title "Impact Of Swimming On Antioxidant Enzyme Status And Oxidative Markers In Old Rats" @default.
- W2011786084 doi "https://doi.org/10.1249/01.mss.0000356082.36576.28" @default.
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