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- W2011788275 abstract "mitosis. Aberrations in key regulators of this process have been found in humanmalignancies associated with chromosomal instability (CIN). Importantchemotherapeutic agents which alter microtubule dynamics such as paclitaxel andvincristine, prolong spindle checkpoint activation and delay the completion ofmitosis. Intriguingly, inhibition of BubR1 or overexpression of Aurora kinase A,spindle checkpoint regulators implicated in CIN, promote resistance to microtubuleinhibitors (MTIs) in vitro. Taxanes have failed to demonstrate significant clinicalbenefit in phase II trials in colorectal cancer (CRC). The high incidence of CIN in thisdisease, coupled with alterations in spindle checkpoint regulators in vivo, may explainthe disappointing results associated with taxane based therapies for CRC. A phase IItrial of taxanes in patients with metastatic CIN negative CRC may be indicated." @default.
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- W2011788275 date "2006-03-30" @default.
- W2011788275 modified "2023-09-26" @default.
- W2011788275 title "Chromosomal Instability, Colorectal Cancer and Taxane Resistance" @default.
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- W2011788275 doi "https://doi.org/10.4161/cc.5.8.2682" @default.
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