Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011792017> ?p ?o ?g. }
- W2011792017 endingPage "11363" @default.
- W2011792017 startingPage "11358" @default.
- W2011792017 abstract "A single HO endonuclease-induced double-strand break (DSB) is sufficient to activate the DNA damage checkpoint and cause Saccharomyces cells to arrest at G 2 /M for 12–14 h, after which cells adapt to the presence of the DSB and resume cell cycle progression. The checkpoint signal leading to G 2 /M arrest was previously shown to be nuclear-limited. Cells lacking ATR-like Mec1 exhibit no DSB-induced cell cycle delay; however, cells lacking Mec1's downstream protein kinase targets, Rad53 or Chk1, still have substantial G 2 /M delay, as do cells lacking securin, Pds1. This delay is eliminated only in the triple mutant chk1 Δ rad53 Δ pds1 Δ, suggesting that Rad53 and Chk1 control targets other than the stability of securin in enforcing checkpoint-mediated cell cycle arrest. The G 2 /M arrest in rad53 Δ and chk1 Δ revealed a unique cytoplasmic phenotype in which there are frequent dynein-dependent excursions of the nucleus through the bud neck, without entering anaphase. Such excursions are infrequent in wild-type arrested cells, but have been observed in cells defective in mitotic exit, including the semidominant cdc5-ad mutation. We suggest that Mec1-dependent checkpoint signaling through Rad53 and Chk1 includes the repression of nuclear movements that are normally associated with the execution of anaphase." @default.
- W2011792017 created "2016-06-24" @default.
- W2011792017 creator A5020032414 @default.
- W2011792017 creator A5048113506 @default.
- W2011792017 creator A5064794018 @default.
- W2011792017 creator A5068057210 @default.
- W2011792017 creator A5078439655 @default.
- W2011792017 date "2007-07-03" @default.
- W2011792017 modified "2023-09-25" @default.
- W2011792017 title "The yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damage" @default.
- W2011792017 cites W1501998216 @default.
- W2011792017 cites W1540274642 @default.
- W2011792017 cites W1589974425 @default.
- W2011792017 cites W1631125692 @default.
- W2011792017 cites W1752089945 @default.
- W2011792017 cites W1965835313 @default.
- W2011792017 cites W1967834407 @default.
- W2011792017 cites W1980725176 @default.
- W2011792017 cites W1983036595 @default.
- W2011792017 cites W1985894701 @default.
- W2011792017 cites W1988887868 @default.
- W2011792017 cites W1989136612 @default.
- W2011792017 cites W1995479856 @default.
- W2011792017 cites W1995843929 @default.
- W2011792017 cites W2003707809 @default.
- W2011792017 cites W2008207595 @default.
- W2011792017 cites W2010325522 @default.
- W2011792017 cites W2011796877 @default.
- W2011792017 cites W2014438192 @default.
- W2011792017 cites W2015224745 @default.
- W2011792017 cites W2027378711 @default.
- W2011792017 cites W2031292590 @default.
- W2011792017 cites W2033754342 @default.
- W2011792017 cites W2035910115 @default.
- W2011792017 cites W2041443477 @default.
- W2011792017 cites W2043895957 @default.
- W2011792017 cites W2047151494 @default.
- W2011792017 cites W2048412849 @default.
- W2011792017 cites W2048599311 @default.
- W2011792017 cites W2048729396 @default.
- W2011792017 cites W2049353065 @default.
- W2011792017 cites W2049356496 @default.
- W2011792017 cites W2050608484 @default.
- W2011792017 cites W2060355419 @default.
- W2011792017 cites W2072937067 @default.
- W2011792017 cites W2078957361 @default.
- W2011792017 cites W2084480566 @default.
- W2011792017 cites W2091204939 @default.
- W2011792017 cites W2100057937 @default.
- W2011792017 cites W2100107095 @default.
- W2011792017 cites W2107130407 @default.
- W2011792017 cites W2116335697 @default.
- W2011792017 cites W2116774827 @default.
- W2011792017 cites W2119318900 @default.
- W2011792017 cites W2126667110 @default.
- W2011792017 cites W2132809415 @default.
- W2011792017 cites W2135607368 @default.
- W2011792017 cites W2137603270 @default.
- W2011792017 cites W2140289804 @default.
- W2011792017 cites W2144709117 @default.
- W2011792017 cites W2147339231 @default.
- W2011792017 cites W2154052847 @default.
- W2011792017 cites W2157681979 @default.
- W2011792017 cites W2158648773 @default.
- W2011792017 cites W2165337946 @default.
- W2011792017 cites W2169794847 @default.
- W2011792017 cites W2169911836 @default.
- W2011792017 doi "https://doi.org/10.1073/pnas.0609636104" @default.
- W2011792017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1896138" @default.
- W2011792017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17586685" @default.
- W2011792017 hasPublicationYear "2007" @default.
- W2011792017 type Work @default.
- W2011792017 sameAs 2011792017 @default.
- W2011792017 citedByCount "39" @default.
- W2011792017 countsByYear W20117920172012 @default.
- W2011792017 countsByYear W20117920172013 @default.
- W2011792017 countsByYear W20117920172014 @default.
- W2011792017 countsByYear W20117920172015 @default.
- W2011792017 countsByYear W20117920172016 @default.
- W2011792017 countsByYear W20117920172017 @default.
- W2011792017 countsByYear W20117920172018 @default.
- W2011792017 countsByYear W20117920172019 @default.
- W2011792017 countsByYear W20117920172020 @default.
- W2011792017 countsByYear W20117920172021 @default.
- W2011792017 countsByYear W20117920172022 @default.
- W2011792017 countsByYear W20117920172023 @default.
- W2011792017 crossrefType "journal-article" @default.
- W2011792017 hasAuthorship W2011792017A5020032414 @default.
- W2011792017 hasAuthorship W2011792017A5048113506 @default.
- W2011792017 hasAuthorship W2011792017A5064794018 @default.
- W2011792017 hasAuthorship W2011792017A5068057210 @default.
- W2011792017 hasAuthorship W2011792017A5078439655 @default.
- W2011792017 hasBestOaLocation W20117920172 @default.
- W2011792017 hasConcept C105696609 @default.
- W2011792017 hasConcept C107888121 @default.
- W2011792017 hasConcept C143425029 @default.
- W2011792017 hasConcept C1491633281 @default.
- W2011792017 hasConcept C153911025 @default.