FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011796667> ?p ?o ?g. }

• W2011796667 endingPage "445" @default.
• W2011796667 startingPage "433" @default.
• W2011796667 abstract "Sox2+ adult mouse pituitary cells can self-renew and terminally differentiate in vitro, but their physiological role in vivo and possible contribution to oncogenesis remain largely unknown. Using genetic lineage tracing, we show here that the Sox2+ cell compartment of both the embryonic and adult pituitary contains stem/progenitor cells that are able to differentiate into all hormone-producing lineages and contribute to organ homeostasis during postnatal life. In addition, we show that targeted expression of oncogenic β-catenin in Sox2+ cells gives rise to pituitary tumors, but, unexpectedly, the tumor mass is not derived from the Sox2+ mutation-sustaining cells, suggesting a paracrine role of Sox2+ cells in pituitary oncogenesis. Our data therefore provide in vivo evidence of a role for Sox2+ stem/progenitor cells in long-term physiological maintenance of the adult pituitary, and highlight an unexpected non-cell-autonomous role for these cells in the induction of pituitary tumors.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI0MDA5YThkZGUxNDlhMzE4MzgwMzc2MzJiZWQ3ZjQ2YyIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NDM1ODI5fQ.qxcfm7Gt4zOP9qWqUCtowQu035yfzplIkpYg-YsU3_U5iufB_N8cVqaJ2wQOPg2OAja-JLSRhBzq-h4gvgHofI23UOQlJ_53ScUdjGNOPGm90cRC6U_cijHs63ktQq0JsD_FwHArA_n5lqxhvwyp9pgmqrizZlv-xKs882689Bd3ZOMsX5QWxpsUHqsnEimlYgTxs6P_EJITqWTQ1o2FmCOqNdfZuXK6oo51vs8vEo1JP9F_ZN6sUUQK-M3qf8DgFpkXMrerFZM-k-aqiIxb1p6dLoXiiPNL2lX5nxbQYEEj8WUzH5SKj4oQKVe0V5nMAENfRsuUrlB1HJ-tadIDCg(mp4, (40.57 MB) Download video" @default.
• W2011796667 created "2016-06-24" @default.
• W2011796667 creator A5001705576 @default.
• W2011796667 creator A5005586607 @default.
• W2011796667 creator A5011527302 @default.
• W2011796667 creator A5013857439 @default.
• W2011796667 creator A5018604282 @default.
• W2011796667 creator A5021476613 @default.
• W2011796667 creator A5029268335 @default.
• W2011796667 creator A5036307719 @default.
• W2011796667 creator A5041085300 @default.
• W2011796667 creator A5046038903 @default.
• W2011796667 creator A5064729919 @default.
• W2011796667 creator A5068539894 @default.
• W2011796667 creator A5070197003 @default.
• W2011796667 date "2013-10-01" @default.
• W2011796667 modified "2023-10-11" @default.
• W2011796667 title "Sox2+ Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential" @default.
• W2011796667 cites W1601683999 @default.
• W2011796667 cites W1964069557 @default.
• W2011796667 cites W1965421802 @default.
• W2011796667 cites W1967768414 @default.
• W2011796667 cites W1970690635 @default.
• W2011796667 cites W1971912541 @default.
• W2011796667 cites W1973255852 @default.
• W2011796667 cites W1973399318 @default.
• W2011796667 cites W1975042974 @default.
• W2011796667 cites W1975957651 @default.
• W2011796667 cites W1989466456 @default.
• W2011796667 cites W1992608406 @default.
• W2011796667 cites W2000754408 @default.
• W2011796667 cites W2002689737 @default.
• W2011796667 cites W2007296754 @default.
• W2011796667 cites W2009409720 @default.
• W2011796667 cites W2010009581 @default.
• W2011796667 cites W2014006702 @default.
• W2011796667 cites W2014078365 @default.
• W2011796667 cites W2018647497 @default.
• W2011796667 cites W2023334774 @default.
• W2011796667 cites W2023443384 @default.
• W2011796667 cites W2024791894 @default.
• W2011796667 cites W2028326666 @default.
• W2011796667 cites W2028360174 @default.
• W2011796667 cites W2029372290 @default.
• W2011796667 cites W2030199762 @default.
• W2011796667 cites W2049887628 @default.
• W2011796667 cites W2053047968 @default.
• W2011796667 cites W2058569154 @default.
• W2011796667 cites W2062978858 @default.
• W2011796667 cites W2064557280 @default.
• W2011796667 cites W2064697437 @default.
• W2011796667 cites W2066362124 @default.
• W2011796667 cites W2066646758 @default.
• W2011796667 cites W2068063316 @default.
• W2011796667 cites W2069064270 @default.
• W2011796667 cites W2071009486 @default.
• W2011796667 cites W2072180663 @default.
• W2011796667 cites W2072379815 @default.
• W2011796667 cites W2072473431 @default.
• W2011796667 cites W2078510083 @default.
• W2011796667 cites W2083274861 @default.
• W2011796667 cites W2084745919 @default.
• W2011796667 cites W2085731232 @default.
• W2011796667 cites W2090364077 @default.
• W2011796667 cites W2090562908 @default.
• W2011796667 cites W2090863421 @default.
• W2011796667 cites W2093358903 @default.
• W2011796667 cites W2094166761 @default.
• W2011796667 cites W2102512718 @default.
• W2011796667 cites W2104397341 @default.
• W2011796667 cites W2109627278 @default.
• W2011796667 cites W2113727201 @default.
• W2011796667 cites W2114881954 @default.
• W2011796667 cites W2117692326 @default.
• W2011796667 cites W2124174391 @default.
• W2011796667 cites W2129622603 @default.
• W2011796667 cites W2134222784 @default.
• W2011796667 cites W2136417710 @default.
• W2011796667 cites W2143187272 @default.
• W2011796667 cites W2155507705 @default.
• W2011796667 cites W2159155233 @default.
• W2011796667 cites W2163360413 @default.
• W2011796667 cites W2171270517 @default.
• W2011796667 doi "https://doi.org/10.1016/j.stem.2013.07.004" @default.
• W2011796667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24094324" @default.
• W2011796667 hasPublicationYear "2013" @default.
• W2011796667 type Work @default.
• W2011796667 sameAs 2011796667 @default.
• W2011796667 citedByCount "240" @default.
• W2011796667 countsByYear W20117966672013 @default.
• W2011796667 countsByYear W20117966672014 @default.
• W2011796667 countsByYear W20117966672015 @default.
• W2011796667 countsByYear W20117966672016 @default.
• W2011796667 countsByYear W20117966672017 @default.
• W2011796667 countsByYear W20117966672018 @default.
• W2011796667 countsByYear W20117966672019 @default.
• W2011796667 countsByYear W20117966672020 @default.
• W2011796667 countsByYear W20117966672021 @default.

• next