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- W2011803601 abstract "Synapse elimination is a hallmark of neural circuit maturation during development. Many synapses are eliminated after an initial phase of synapse formation. However, little is known about the molecular machinery that executes synaptic elimination or why certain synapses are selectively eliminated while other synapses persist and grow. Ding et al . (see the Perspective by Miller) examined synapse elimination in the nematode worm and found that a ubiquitin E3 ligase complex plays a key role. The activity of the ubiquitin-proteasome system was tightly regulated by a synaptic adhesion molecule, which protected certain synapses from selective elimination. M. Ding, D. Chao, G. Wang, K. Shen, Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317 , 947-951 (2007). [Abstract][Full Text] D. M. Miller, Synapses here and not everywhere. Science 317 , 907-908 (2007). [Summary][Full Text]" @default.
- W2011803601 created "2016-06-24" @default.
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- W2011803601 date "2007-08-14" @default.
- W2011803601 modified "2023-09-26" @default.
- W2011803601 title "Understanding Selective Synapse Elimination" @default.
- W2011803601 doi "https://doi.org/10.1126/stke.4002007tw305" @default.
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