FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011808534> ?p ?o ?g. }

• W2011808534 endingPage "e1002387" @default.
• W2011808534 startingPage "e1002387" @default.
• W2011808534 abstract "The RRM-type RNA-binding protein Mei2 is a master regulator of meiosis in fission yeast, in which it stabilizes meiosis-specific mRNAs by blocking their destruction. Artificial activation of Mei2 can provoke the entire meiotic process, and it is suspected that Mei2 may do more than the stabilization of meiosis-specific mRNAs. In our current study using a new screening system, we show that Mei2 genetically interacts with subunits of CTDK-I, which phosphorylates serine-2 residues on the C-terminal domain of RNA polymerase II (Pol II CTD). Phosphorylation of CTD Ser-2 is essential to enable the robust transcription of ste11, which encodes an HMG-type transcription factor that regulates the expression of mei2 and other genes necessary for sexual development. CTD Ser-2 phosphorylation increases under nitrogen starvation, and the stress-responsive MAP kinase pathway, mediated by Wis1 MAPKK and Sty1 MAPK, is critical for this stress response. Sty1 phosphorylates Lsk1, the catalytic subunit of CTDK-I. Furthermore, a feedback loop stemming from activated Mei2 to Win1 and Wis4 MAPKKKs operates in this pathway and eventually enhances CTD Ser-2 phosphorylation and ste11 transcription. Hence, in addition to starting meiosis, Mei2 functions to reinforce the commitment to it, once cells have entered this process. This study also demonstrates clearly that the stress-responsive MAP kinase pathway can modulates gene expression through phosphorylation of Pol II CTD." @default.
• W2011808534 created "2016-06-24" @default.
• W2011808534 creator A5044606274 @default.
• W2011808534 creator A5045447879 @default.
• W2011808534 creator A5058863706 @default.
• W2011808534 date "2011-12-01" @default.
• W2011808534 modified "2023-10-03" @default.
• W2011808534 title "The Fission Yeast Stress-Responsive MAPK Pathway Promotes Meiosis via the Phosphorylation of Pol II CTD in Response to Environmental and Feedback Cues" @default.
• W2011808534 cites W1575910125 @default.
• W2011808534 cites W1780581171 @default.
• W2011808534 cites W1797931385 @default.
• W2011808534 cites W1798315881 @default.
• W2011808534 cites W1844366679 @default.
• W2011808534 cites W1969636175 @default.
• W2011808534 cites W1973525422 @default.
• W2011808534 cites W1988972530 @default.
• W2011808534 cites W2001398687 @default.
• W2011808534 cites W2004408181 @default.
• W2011808534 cites W2007245783 @default.
• W2011808534 cites W2008240036 @default.
• W2011808534 cites W2010781201 @default.
• W2011808534 cites W2011369177 @default.
• W2011808534 cites W2012600705 @default.
• W2011808534 cites W2013094037 @default.
• W2011808534 cites W2015267380 @default.
• W2011808534 cites W2018745636 @default.
• W2011808534 cites W2018876412 @default.
• W2011808534 cites W2019797615 @default.
• W2011808534 cites W2023622291 @default.
• W2011808534 cites W2027950141 @default.
• W2011808534 cites W2032241710 @default.
• W2011808534 cites W2032624656 @default.
• W2011808534 cites W2037237823 @default.
• W2011808534 cites W2042368221 @default.
• W2011808534 cites W2045959839 @default.
• W2011808534 cites W2049017158 @default.
• W2011808534 cites W2054229788 @default.
• W2011808534 cites W2055684843 @default.
• W2011808534 cites W2069297824 @default.
• W2011808534 cites W2075384741 @default.
• W2011808534 cites W2076426204 @default.
• W2011808534 cites W2093728614 @default.
• W2011808534 cites W2100254469 @default.
• W2011808534 cites W2101288641 @default.
• W2011808534 cites W2103010558 @default.
• W2011808534 cites W2111586212 @default.
• W2011808534 cites W2119385226 @default.
• W2011808534 cites W2123789526 @default.
• W2011808534 cites W2132197721 @default.
• W2011808534 cites W2133632082 @default.
• W2011808534 cites W2134618983 @default.
• W2011808534 cites W2134809769 @default.
• W2011808534 cites W2139910083 @default.
• W2011808534 cites W2141976844 @default.
• W2011808534 cites W2157154516 @default.
• W2011808534 cites W2167708645 @default.
• W2011808534 cites W2171171901 @default.
• W2011808534 cites W2194986544 @default.
• W2011808534 cites W2236011578 @default.
• W2011808534 cites W279224186 @default.
• W2011808534 cites W79957767 @default.
• W2011808534 doi "https://doi.org/10.1371/journal.pgen.1002387" @default.
• W2011808534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3228818" @default.
• W2011808534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22144909" @default.
• W2011808534 hasPublicationYear "2011" @default.
• W2011808534 type Work @default.
• W2011808534 sameAs 2011808534 @default.
• W2011808534 citedByCount "37" @default.
• W2011808534 countsByYear W20118085342012 @default.
• W2011808534 countsByYear W20118085342013 @default.
• W2011808534 countsByYear W20118085342014 @default.
• W2011808534 countsByYear W20118085342015 @default.
• W2011808534 countsByYear W20118085342016 @default.
• W2011808534 countsByYear W20118085342017 @default.
• W2011808534 countsByYear W20118085342018 @default.
• W2011808534 countsByYear W20118085342019 @default.
• W2011808534 countsByYear W20118085342020 @default.
• W2011808534 countsByYear W20118085342023 @default.
• W2011808534 crossrefType "journal-article" @default.
• W2011808534 hasAuthorship W2011808534A5044606274 @default.
• W2011808534 hasAuthorship W2011808534A5045447879 @default.
• W2011808534 hasAuthorship W2011808534A5058863706 @default.
• W2011808534 hasBestOaLocation W20118085341 @default.
• W2011808534 hasConcept C101762097 @default.
• W2011808534 hasConcept C104317684 @default.
• W2011808534 hasConcept C111368507 @default.
• W2011808534 hasConcept C11960822 @default.
• W2011808534 hasConcept C125533998 @default.
• W2011808534 hasConcept C127313418 @default.
• W2011808534 hasConcept C138885662 @default.
• W2011808534 hasConcept C148196450 @default.
• W2011808534 hasConcept C150194340 @default.
• W2011808534 hasConcept C179926584 @default.
• W2011808534 hasConcept C41895202 @default.
• W2011808534 hasConcept C54355233 @default.
• W2011808534 hasConcept C57074206 @default.
• W2011808534 hasConcept C62478195 @default.
• W2011808534 hasConcept C64350747 @default.

• next