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- W2011816049 endingPage "933" @default.
- W2011816049 startingPage "861" @default.
- W2011816049 abstract "The chapter discusses the various drug-induced changes in the nervous system and special sense organs. Adverse drug reactions that involve the nervous system are quite common in patients, although they are diverse in nature and pathogenesis. Psychiatric symptoms are an uncommon but important complication of nonsteroidal anti-inflammatory drugs because of their widespread usage. Findings reveal that animals are generally rather poor predictors of subjective neurological effects, but they perform much better for prediction of potentially serious structural effects. A reasonable degree of concordance has been seen where effects on the central nervous system have been assessed in conventional toxicity studies using both clinical monitoring and the histopathological examination of the brain and nervous tissue. Damaged neurons show a variety of histological appearances. They may be vacuolated, swollen, shrunken, or dark staining, typically with indistinct Nissl substance. In animals treated with the widely used anticonvulsant phenytoin, a reduction in the number of Purkinje fibers was observed. Findings also show that the administration of cationic amphiphilic drugs, such as chloroquine, tricyclic antidepressants, chlorphentermine, and tamoxifen to laboratory animals is associated with the accumulation of phospholipids or polar lipids phospholipidosis." @default.
- W2011816049 created "2016-06-24" @default.
- W2011816049 creator A5053371660 @default.
- W2011816049 date "2007-01-01" @default.
- W2011816049 modified "2023-10-18" @default.
- W2011816049 title "Nervous System and Special Sense Organs" @default.
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