FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011824272> ?p ?o ?g. }

• W2011824272 endingPage "240" @default.
• W2011824272 startingPage "221" @default.
• W2011824272 abstract "Cellular aging is characterized by alterations at both the morphological and molecular levels, some of which are decreased mitotic rate, increased cytoplasmic vacuolization, and changes in intrinsic cellular constituents (Stanulis-Praeger, 1987. Mech. Ageing Dev. 38, 1-48). In the present investigation, glycoxidation is studied as a marker for cellular aging by measuring cell-associated pentosidine levels in human skin fibroblasts as a function of replicative life span and in human peripheral blood T lymphocytes as a function of chronological age. Fibroblasts were isolated from culture by detachment/centrifugation while lymphocytes were isolated from blood by a Ficoll-Paque/Lympho-Kwik T-Cell Prep technique. Pentosidine levels were measured in acid-hydrolyzed cell pellet suspensions by high-pressure liquid chromatography. Results show that pentosidine was detected in early and late cultured reticular and papillary fibroblasts. Pentosidine, expressed as either protein, DNA, or cell number, significantly (P < 0.0006) increased with in vitro passage and was significantly (P < 0.01) related to cell proliferation as measured by cell density and cell doublings per day during culture. Cell-associated pentosidine was measured in T lymphocytes isolated from healthy, diabetic, and uremic individuals. In healthy controls, levels significantly (P < 0.0003) increased with age. In uremic individuals, a large variation was observed with many values above the 95% confidence intervals determined for controls. Since a previous study showed that plasma pentosidine in healthy subjects does not increase with age, these results suggest that cellular turnover perhaps coupled to a deterioration in cellular anti-glycoxidation defensive mechanisms play a substantial role in explaining increased pentosidine concentrations during cellular aging." @default.
• W2011824272 created "2016-06-24" @default.
• W2011824272 creator A5019046192 @default.
• W2011824272 creator A5028705322 @default.
• W2011824272 creator A5029026718 @default.
• W2011824272 creator A5048439423 @default.
• W2011824272 creator A5053734089 @default.
• W2011824272 creator A5086991293 @default.
• W2011824272 date "1998-11-01" @default.
• W2011824272 modified "2023-10-09" @default.
• W2011824272 title "Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo" @default.
• W2011824272 cites W124089946 @default.
• W2011824272 cites W1503291459 @default.
• W2011824272 cites W1506520614 @default.
• W2011824272 cites W1518714662 @default.
• W2011824272 cites W1532082751 @default.
• W2011824272 cites W1557253076 @default.
• W2011824272 cites W1572011530 @default.
• W2011824272 cites W1602367925 @default.
• W2011824272 cites W1965076280 @default.
• W2011824272 cites W1969185047 @default.
• W2011824272 cites W1973479040 @default.
• W2011824272 cites W1973820243 @default.
• W2011824272 cites W1976340479 @default.
• W2011824272 cites W1977779461 @default.
• W2011824272 cites W1978900828 @default.
• W2011824272 cites W1981718074 @default.
• W2011824272 cites W1982064412 @default.
• W2011824272 cites W1983945268 @default.
• W2011824272 cites W1987846783 @default.
• W2011824272 cites W1998703293 @default.
• W2011824272 cites W2007804077 @default.
• W2011824272 cites W2008826807 @default.
• W2011824272 cites W2010754688 @default.
• W2011824272 cites W2014671896 @default.
• W2011824272 cites W2029457074 @default.
• W2011824272 cites W2039639826 @default.
• W2011824272 cites W2051945336 @default.
• W2011824272 cites W2059123383 @default.
• W2011824272 cites W2059304499 @default.
• W2011824272 cites W2067829426 @default.
• W2011824272 cites W2071595316 @default.
• W2011824272 cites W2071673220 @default.
• W2011824272 cites W2072692635 @default.
• W2011824272 cites W2074315240 @default.
• W2011824272 cites W2075879120 @default.
• W2011824272 cites W2084674106 @default.
• W2011824272 cites W2088590772 @default.
• W2011824272 cites W2092392512 @default.
• W2011824272 cites W2093245779 @default.
• W2011824272 cites W2097841537 @default.
• W2011824272 cites W2104908670 @default.
• W2011824272 cites W2108448809 @default.
• W2011824272 cites W2115337518 @default.
• W2011824272 cites W2125826913 @default.
• W2011824272 cites W2139403145 @default.
• W2011824272 cites W2139942097 @default.
• W2011824272 cites W2143324145 @default.
• W2011824272 cites W2150844478 @default.
• W2011824272 cites W2164719183 @default.
• W2011824272 cites W2322343093 @default.
• W2011824272 cites W4313376843 @default.
• W2011824272 cites W57282063 @default.
• W2011824272 cites W820854987 @default.
• W2011824272 doi "https://doi.org/10.1016/s0047-6374(98)00090-6" @default.
• W2011824272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9862232" @default.
• W2011824272 hasPublicationYear "1998" @default.
• W2011824272 type Work @default.
• W2011824272 sameAs 2011824272 @default.
• W2011824272 citedByCount "21" @default.
• W2011824272 countsByYear W20118242722015 @default.
• W2011824272 countsByYear W20118242722016 @default.
• W2011824272 countsByYear W20118242722020 @default.
• W2011824272 countsByYear W20118242722021 @default.
• W2011824272 crossrefType "journal-article" @default.
• W2011824272 hasAuthorship W2011824272A5019046192 @default.
• W2011824272 hasAuthorship W2011824272A5028705322 @default.
• W2011824272 hasAuthorship W2011824272A5029026718 @default.
• W2011824272 hasAuthorship W2011824272A5048439423 @default.
• W2011824272 hasAuthorship W2011824272A5053734089 @default.
• W2011824272 hasAuthorship W2011824272A5086991293 @default.
• W2011824272 hasConcept C126322002 @default.
• W2011824272 hasConcept C134018914 @default.
• W2011824272 hasConcept C147990577 @default.
• W2011824272 hasConcept C1491633281 @default.
• W2011824272 hasConcept C153911025 @default.
• W2011824272 hasConcept C16685009 @default.
• W2011824272 hasConcept C185592680 @default.
• W2011824272 hasConcept C202751555 @default.
• W2011824272 hasConcept C207001950 @default.
• W2011824272 hasConcept C2780758796 @default.
• W2011824272 hasConcept C54355233 @default.
• W2011824272 hasConcept C55493867 @default.
• W2011824272 hasConcept C555293320 @default.
• W2011824272 hasConcept C62112901 @default.
• W2011824272 hasConcept C71924100 @default.
• W2011824272 hasConcept C81885089 @default.
• W2011824272 hasConcept C86803240 @default.

• next