FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011825243> ?p ?o ?g. }

• W2011825243 endingPage "1635.e2" @default.
• W2011825243 startingPage "1628" @default.
• W2011825243 abstract "Influx of extracellular Ca(2+) into human lung mast cells (HLMCs) is essential for the FcεRI-dependent release of preformed granule-derived mediators and newly synthesized autacoids and cytokines. However, the identity of the ion channels underlying this Ca(2+) influx is unknown. The recently discovered members of the CRACM/Orai ion channel family that carries the Ca(2+) release-activated Ca(2+) current are candidates.To investigate the expression and function of CRACM channels in HLMCs.CRACM mRNA, protein, and functional expression were examined in purified HLMCs and isolated human bronchus.CRACM1, -2, and -3 mRNA transcripts and CRACM1 and -2 proteins were detectable in HLMCs. A CRACM-like current was detected following FcεRI-dependent HLMC activation and also in HLMCs dialyzed with 30 μM inositol triphosphate. The Ca(2+)-selective current obtained under both conditions was blocked by 10 μM La(3+) and Gd(3+), known blockers of CRACM channels, and 2 distinct and specific CRACM-channel blockers-GSK-7975A and Synta-66. Both blockers reduced FcεRI-dependent Ca(2+) influx, and 3 μM GSK-7975A and Synta-66 reduced the release of histamine, leukotriene C(4), and cytokines (IL-5/-8/-13 and TNFα) by up to 50%. Synta-66 also inhibited allergen-dependent bronchial smooth muscle contraction in ex vivo tissue.The presence of CRACM channels, a CRACM-like current, and functional inhibition of HLMC Ca(2+) influx, mediator release, and allergen-induced bronchial smooth muscle contraction by CRACM-channel blockers supports a role for CRACM channels in FcεRI-dependent HLMC secretion. CRACM channels are therefore a potential therapeutic target in the treatment of asthma and related allergic diseases." @default.
• W2011825243 created "2016-06-24" @default.
• W2011825243 creator A5000711773 @default.
• W2011825243 creator A5017323068 @default.
• W2011825243 creator A5034193600 @default.
• W2011825243 creator A5043495928 @default.
• W2011825243 creator A5049609214 @default.
• W2011825243 creator A5090997141 @default.
• W2011825243 date "2012-06-01" @default.
• W2011825243 modified "2023-10-18" @default.
• W2011825243 title "CRACM/Orai ion channel expression and function in human lung mast cells" @default.
• W2011825243 cites W1575766207 @default.
• W2011825243 cites W1968924035 @default.
• W2011825243 cites W1991534768 @default.
• W2011825243 cites W2001917660 @default.
• W2011825243 cites W2009667219 @default.
• W2011825243 cites W2012228357 @default.
• W2011825243 cites W2015480034 @default.
• W2011825243 cites W2019855265 @default.
• W2011825243 cites W2020708758 @default.
• W2011825243 cites W2021033207 @default.
• W2011825243 cites W2028975474 @default.
• W2011825243 cites W2029301182 @default.
• W2011825243 cites W2031966403 @default.
• W2011825243 cites W2044562348 @default.
• W2011825243 cites W2049374822 @default.
• W2011825243 cites W2052634469 @default.
• W2011825243 cites W2056997999 @default.
• W2011825243 cites W2058622754 @default.
• W2011825243 cites W2058788414 @default.
• W2011825243 cites W2059989081 @default.
• W2011825243 cites W2060201104 @default.
• W2011825243 cites W2074144612 @default.
• W2011825243 cites W2080361138 @default.
• W2011825243 cites W2096437759 @default.
• W2011825243 cites W2109380465 @default.
• W2011825243 cites W2111474925 @default.
• W2011825243 cites W2122252195 @default.
• W2011825243 cites W2127855108 @default.
• W2011825243 cites W2132604531 @default.
• W2011825243 cites W2137258759 @default.
• W2011825243 cites W2146341872 @default.
• W2011825243 cites W2159356105 @default.
• W2011825243 cites W2159938460 @default.
• W2011825243 cites W2163789582 @default.
• W2011825243 cites W2397083413 @default.
• W2011825243 doi "https://doi.org/10.1016/j.jaci.2012.01.070" @default.
• W2011825243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3526795" @default.
• W2011825243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22409987" @default.
• W2011825243 hasPublicationYear "2012" @default.
• W2011825243 type Work @default.
• W2011825243 sameAs 2011825243 @default.
• W2011825243 citedByCount "61" @default.
• W2011825243 countsByYear W20118252432012 @default.
• W2011825243 countsByYear W20118252432013 @default.
• W2011825243 countsByYear W20118252432014 @default.
• W2011825243 countsByYear W20118252432015 @default.
• W2011825243 countsByYear W20118252432016 @default.
• W2011825243 countsByYear W20118252432017 @default.
• W2011825243 countsByYear W20118252432018 @default.
• W2011825243 countsByYear W20118252432019 @default.
• W2011825243 countsByYear W20118252432020 @default.
• W2011825243 countsByYear W20118252432021 @default.
• W2011825243 countsByYear W20118252432022 @default.
• W2011825243 countsByYear W20118252432023 @default.
• W2011825243 crossrefType "journal-article" @default.
• W2011825243 hasAuthorship W2011825243A5000711773 @default.
• W2011825243 hasAuthorship W2011825243A5017323068 @default.
• W2011825243 hasAuthorship W2011825243A5034193600 @default.
• W2011825243 hasAuthorship W2011825243A5043495928 @default.
• W2011825243 hasAuthorship W2011825243A5049609214 @default.
• W2011825243 hasAuthorship W2011825243A5090997141 @default.
• W2011825243 hasBestOaLocation W20118252431 @default.
• W2011825243 hasConcept C1122143 @default.
• W2011825243 hasConcept C126322002 @default.
• W2011825243 hasConcept C134018914 @default.
• W2011825243 hasConcept C149588370 @default.
• W2011825243 hasConcept C153461711 @default.
• W2011825243 hasConcept C170493617 @default.
• W2011825243 hasConcept C178790620 @default.
• W2011825243 hasConcept C185592680 @default.
• W2011825243 hasConcept C28406088 @default.
• W2011825243 hasConcept C50254741 @default.
• W2011825243 hasConcept C519063684 @default.
• W2011825243 hasConcept C55493867 @default.
• W2011825243 hasConcept C71924100 @default.
• W2011825243 hasConcept C86803240 @default.
• W2011825243 hasConcept C95444343 @default.
• W2011825243 hasConcept C98274493 @default.
• W2011825243 hasConceptScore W2011825243C1122143 @default.
• W2011825243 hasConceptScore W2011825243C126322002 @default.
• W2011825243 hasConceptScore W2011825243C134018914 @default.
• W2011825243 hasConceptScore W2011825243C149588370 @default.
• W2011825243 hasConceptScore W2011825243C153461711 @default.
• W2011825243 hasConceptScore W2011825243C170493617 @default.
• W2011825243 hasConceptScore W2011825243C178790620 @default.
• W2011825243 hasConceptScore W2011825243C185592680 @default.
• W2011825243 hasConceptScore W2011825243C28406088 @default.

• next