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• W2011837112 endingPage "749" @default.
• W2011837112 startingPage "738" @default.
• W2011837112 abstract "It is becoming increasingly clear that any human immunodeficiency virus (HIV) vaccine should induce a strong CD8(+) response. Additional desirable elements are multispecificity and a focus on conserved epitopes. The use of multiple conserved epitopes arranged in an artificial gene (or EpiGene) is a potential means to achieve these goals. To test this concept in a relevant disease model we sought to identify multiple simian immunodeficiency virus (SIV)-derived CD8(+) epitopes bound by a single nonhuman primate major histocompatibility complex (MHC) class I molecule. We had previously identified the peptide binding motif of Mamu-A*01(2), a common rhesus macaque MHC class I molecule that presents the immunodominant SIV gag-derived cytotoxic T lymphocyte (CTL) epitope Gag_CM9 (CTPYDINQM). Herein, we scanned SIV proteins for the presence of Mamu-A*01 motifs. The binding capacity of 221 motif-positive peptides was determined using purified Mamu-A*01 molecules. Thirty-seven peptides bound with apparent K(d) values of 500 nM or lower, with 21 peptides binding better than the Gag_CM9 peptide. Peripheral blood mononuclear cells from SIV-infected Mamu-A*01(+) macaques recognized 14 of these peptides in ELISPOT, CTL, or tetramer analyses. This study reveals an unprecedented complexity and diversity of anti-SIV CTL responses. Furthermore, it represents an important step toward the design of a multiepitope vaccine for SIV and HIV." @default.
• W2011837112 created "2016-06-24" @default.
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• W2011837112 date "2001-01-15" @default.
• W2011837112 modified "2023-10-16" @default.
• W2011837112 title "CD8⁺Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing" @default.
• W2011837112 cites W1481440696 @default.
• W2011837112 cites W1490227519 @default.
• W2011837112 cites W1504747402 @default.
• W2011837112 cites W1522955777 @default.
• W2011837112 cites W1537609529 @default.
• W2011837112 cites W1555983429 @default.
• W2011837112 cites W1571431813 @default.
• W2011837112 cites W1632505095 @default.
• W2011837112 cites W1655510925 @default.
• W2011837112 cites W1675195038 @default.
• W2011837112 cites W170789578 @default.
• W2011837112 cites W1808985647 @default.
• W2011837112 cites W1817144267 @default.
• W2011837112 cites W1870163703 @default.
• W2011837112 cites W1870288261 @default.
• W2011837112 cites W1893651774 @default.
• W2011837112 cites W1919528337 @default.
• W2011837112 cites W1928100000 @default.
• W2011837112 cites W1965569618 @default.
• W2011837112 cites W1969057879 @default.
• W2011837112 cites W1973345938 @default.
• W2011837112 cites W1986152436 @default.
• W2011837112 cites W1987888541 @default.
• W2011837112 cites W2001132089 @default.
• W2011837112 cites W2001899369 @default.
• W2011837112 cites W2003227439 @default.
• W2011837112 cites W2005363462 @default.
• W2011837112 cites W2009373697 @default.
• W2011837112 cites W2011744761 @default.
• W2011837112 cites W2021550859 @default.
• W2011837112 cites W2027384017 @default.
• W2011837112 cites W2037415719 @default.
• W2011837112 cites W2048999843 @default.
• W2011837112 cites W2052325775 @default.
• W2011837112 cites W2061808278 @default.
• W2011837112 cites W2065879670 @default.
• W2011837112 cites W20663261 @default.
• W2011837112 cites W2067069532 @default.
• W2011837112 cites W2068879526 @default.
• W2011837112 cites W2073254456 @default.
• W2011837112 cites W2073551846 @default.
• W2011837112 cites W2076046390 @default.
• W2011837112 cites W2077348914 @default.
• W2011837112 cites W2079504777 @default.
• W2011837112 cites W2080980504 @default.
• W2011837112 cites W2085919513 @default.
• W2011837112 cites W2088308807 @default.
• W2011837112 cites W2093218866 @default.
• W2011837112 cites W2097398162 @default.
• W2011837112 cites W2097623691 @default.
• W2011837112 cites W2098112251 @default.
• W2011837112 cites W2100587714 @default.
• W2011837112 cites W2103182811 @default.
• W2011837112 cites W2108028766 @default.
• W2011837112 cites W2108730570 @default.
• W2011837112 cites W2120320343 @default.
• W2011837112 cites W2124969212 @default.
• W2011837112 cites W2127508135 @default.
• W2011837112 cites W2129114331 @default.
• W2011837112 cites W2133402813 @default.
• W2011837112 cites W2134351140 @default.
• W2011837112 cites W2136045513 @default.
• W2011837112 cites W2137187732 @default.
• W2011837112 cites W2137267461 @default.
• W2011837112 cites W2138604744 @default.
• W2011837112 cites W2139257243 @default.
• W2011837112 cites W2144882745 @default.
• W2011837112 cites W2146706646 @default.
• W2011837112 cites W2151838794 @default.
• W2011837112 cites W2164339006 @default.
• W2011837112 cites W2171034382 @default.
• W2011837112 cites W2171499092 @default.
• W2011837112 cites W2412053990 @default.
• W2011837112 cites W2419419980 @default.
• W2011837112 cites W2971856643 @default.
• W2011837112 cites W4313342455 @default.
• W2011837112 cites W47200848 @default.
• W2011837112 doi "https://doi.org/10.1128/jvi.75.2.738-749.2001" @default.
• W2011837112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/113970" @default.

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