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• W2011837287 abstract "Many diseases are associated with the overproduction of hydroperoxides that inflict cell damage. A novel cyclodextrin derivative, 6A,6B-diseleninic acid-6A',6B'-selenium bridged beta-cyclodextrin (6-diSeCD), was synthesized to be a functional mimic of glutathione peroxidase (GPX) that normally removes these hydroperoxides. The mimic had high catalytic GPX activity of 13.5 U/micromol, which is 13.6-fold higher than ebselen (PZ51), and was chemically and biologically stable in vitro. Antioxidant activity was studied by ferrous sulfate/ascorbate-induced mitochondria damage model system. These data show that the mimic has great antioxidant activity. Such mimics may result in better clinical therapies for diseases mediated by hydroperoxides." @default.
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• W2011837287 date "2001-03-01" @default.
• W2011837287 modified "2023-10-03" @default.
• W2011837287 title "A Novel Glutathione Peroxidase Mimic with Antioxidant Activity" @default.
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• W2011837287 doi "https://doi.org/10.1006/abbi.2000.2238" @default.
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