FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011837774> ?p ?o ?g. }

• W2011837774 endingPage "3237" @default.
• W2011837774 startingPage "3229" @default.
• W2011837774 abstract "The PBP2a is a cell wall synthesizing protein, which causes resistivity in methicillin resistant Staphylococcus aureus (MRSA) from β-lactam antibiotics but it is susceptible to 5th generation cephalosporin, ceftobiprole. Ceftobiprole inhibits the growth of MRSA by targeting the PBP2a-mediated cell wall synthesis, but it is reported to have adverse side effects. Due to this, there is a constant need to develop natural alternatives, which are generally free from adverse side effects. Hence in this study, in silico based docking analysis was performed with 37 quercetin derivatives towards PBP2a inhibition and their efficiencies were compared with β-lactam antibiotic, ceftobiprole. The docking studies suggested that quercetin 3-O-rutinoside (ZINC5280805) interacted efficiently with PBP2a, attaining the highest LibDock score (187.32) compared to other quercetin derivatives. The structural stability and dynamics of the identified lead with PBP2a were validated through molecular dynamics simulation. Simulation results such as RMSD, RMSF, and Rg values indicated that the stability of quercetin 3-O-rutinoside with PBP2a was better, with respect to the un-ligated PBP2a. Furthermore, the quercetin 3-O-rutinoside was subjected to an antibacterial susceptibility test and found to have antibacterial activity at 500, 700, and 900 μM concentration. Also, morphological changes in the bacterial colony and bacterial surface were observed using a scanning electron microscope, when MRSA was treated with 900 μM concentration of quercetin 3-O-rutinoside. Collectively, results from this study suggest that the quercetin 3-O-rutinoside has the capability to inhibit PBP2a and hence could be used as an alternative or in combination with other drugs in treating MRSA infection." @default.
• W2011837774 created "2016-06-24" @default.
• W2011837774 creator A5005363336 @default.
• W2011837774 creator A5024027519 @default.
• W2011837774 creator A5066804730 @default.
• W2011837774 creator A5069228406 @default.
• W2011837774 date "2014-09-25" @default.
• W2011837774 modified "2023-10-16" @default.
• W2011837774 title "Quercetin 3-O-rutinoside mediated inhibition of PBP2a: computational and experimental evidence to its anti-MRSA activity" @default.
• W2011837774 cites W1576773087 @default.
• W2011837774 cites W1929704568 @default.
• W2011837774 cites W1966078827 @default.
• W2011837774 cites W1975623001 @default.
• W2011837774 cites W1983035144 @default.
• W2011837774 cites W1985530063 @default.
• W2011837774 cites W1985588649 @default.
• W2011837774 cites W1991297745 @default.
• W2011837774 cites W1992967507 @default.
• W2011837774 cites W2011697200 @default.
• W2011837774 cites W2036989796 @default.
• W2011837774 cites W2041877302 @default.
• W2011837774 cites W2052038479 @default.
• W2011837774 cites W2065013018 @default.
• W2011837774 cites W2065078821 @default.
• W2011837774 cites W2071791280 @default.
• W2011837774 cites W2074570966 @default.
• W2011837774 cites W2081912151 @default.
• W2011837774 cites W2086779432 @default.
• W2011837774 cites W2093221728 @default.
• W2011837774 cites W2103459618 @default.
• W2011837774 cites W2109915370 @default.
• W2011837774 cites W2111611477 @default.
• W2011837774 cites W2119877522 @default.
• W2011837774 cites W2126874955 @default.
• W2011837774 cites W2135298229 @default.
• W2011837774 cites W2148488439 @default.
• W2011837774 cites W2161593000 @default.
• W2011837774 cites W2163279482 @default.
• W2011837774 cites W2344454939 @default.
• W2011837774 doi "https://doi.org/10.1039/c4mb00319e" @default.
• W2011837774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25286279" @default.
• W2011837774 hasPublicationYear "2014" @default.
• W2011837774 type Work @default.
• W2011837774 sameAs 2011837774 @default.
• W2011837774 citedByCount "8" @default.
• W2011837774 countsByYear W20118377742016 @default.
• W2011837774 countsByYear W20118377742017 @default.
• W2011837774 countsByYear W20118377742020 @default.
• W2011837774 countsByYear W20118377742022 @default.
• W2011837774 countsByYear W20118377742023 @default.
• W2011837774 crossrefType "journal-article" @default.
• W2011837774 hasAuthorship W2011837774A5005363336 @default.
• W2011837774 hasAuthorship W2011837774A5024027519 @default.
• W2011837774 hasAuthorship W2011837774A5066804730 @default.
• W2011837774 hasAuthorship W2011837774A5069228406 @default.
• W2011837774 hasConcept C104317684 @default.
• W2011837774 hasConcept C185592680 @default.
• W2011837774 hasConcept C2775905019 @default.
• W2011837774 hasConcept C2778004101 @default.
• W2011837774 hasConcept C2779489039 @default.
• W2011837774 hasConcept C2780104969 @default.
• W2011837774 hasConcept C2781263971 @default.
• W2011837774 hasConcept C3019249092 @default.
• W2011837774 hasConcept C41685203 @default.
• W2011837774 hasConcept C42972112 @default.
• W2011837774 hasConcept C501593827 @default.
• W2011837774 hasConcept C523546767 @default.
• W2011837774 hasConcept C54355233 @default.
• W2011837774 hasConcept C55493867 @default.
• W2011837774 hasConcept C64778159 @default.
• W2011837774 hasConcept C71240020 @default.
• W2011837774 hasConcept C71924100 @default.
• W2011837774 hasConcept C86803240 @default.
• W2011837774 hasConcept C89423630 @default.
• W2011837774 hasConceptScore W2011837774C104317684 @default.
• W2011837774 hasConceptScore W2011837774C185592680 @default.
• W2011837774 hasConceptScore W2011837774C2775905019 @default.
• W2011837774 hasConceptScore W2011837774C2778004101 @default.
• W2011837774 hasConceptScore W2011837774C2779489039 @default.
• W2011837774 hasConceptScore W2011837774C2780104969 @default.
• W2011837774 hasConceptScore W2011837774C2781263971 @default.
• W2011837774 hasConceptScore W2011837774C3019249092 @default.
• W2011837774 hasConceptScore W2011837774C41685203 @default.
• W2011837774 hasConceptScore W2011837774C42972112 @default.
• W2011837774 hasConceptScore W2011837774C501593827 @default.
• W2011837774 hasConceptScore W2011837774C523546767 @default.
• W2011837774 hasConceptScore W2011837774C54355233 @default.
• W2011837774 hasConceptScore W2011837774C55493867 @default.
• W2011837774 hasConceptScore W2011837774C64778159 @default.
• W2011837774 hasConceptScore W2011837774C71240020 @default.
• W2011837774 hasConceptScore W2011837774C71924100 @default.
• W2011837774 hasConceptScore W2011837774C86803240 @default.
• W2011837774 hasConceptScore W2011837774C89423630 @default.
• W2011837774 hasIssue "12" @default.
• W2011837774 hasLocation W20118377741 @default.
• W2011837774 hasLocation W20118377742 @default.
• W2011837774 hasOpenAccess W2011837774 @default.
• W2011837774 hasPrimaryLocation W20118377741 @default.

• next