FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011852093> ?p ?o ?g. }

• W2011852093 endingPage "53" @default.
• W2011852093 startingPage "44" @default.
• W2011852093 abstract "Imatinib, nilotinib and dasatinib are protein kinase inhibitors which target the tyrosine kinase activity of the Breakpoint Cluster Region-Abelson kinase (BCR-ABL) and are used to treat chronic myelogenous leukemia. Recently, using a chemical proteomics approach another tyrosine kinase, the collagen receptor Discoidin Domain Receptor1 (DDR1) has also been identified as a potential target of these compounds. To further investigate the interaction of imatinib, nilotinib and dasatinib with DDR1 kinase we cloned and expressed human DDR1 and developed biochemical and cellular functional assays to assess their activity against DDR1 and the related receptor tyrosine kinase Discoidin Domain Receptor2 (DDR2). Our studies demonstrate that all 3 compounds are potent inhibitors of the kinase activity of both DDR1 and DDR2. In order to investigate the question of selectivity among DDR1, DDR2 and other tyrosine kinases we have aligned DDR1 and DDR2 protein sequences to other closely related members of the receptor tyrosine kinase family such as Muscle Specific Kinase (MUSK), insulin receptor (INSR), Abelson kinase (c-ABL), and the stem cell factor receptor (c-KIT) and have built homology models for the DDR1 and DDR2 kinase domains. In spite of high similarity among these kinases we show that there are differences within the ATP–phosphate binding loop (P-loop), which could be exploited to obtain kinase selective compounds. Furthermore, the potent DDR1 and DDR2 inhibitory activity of imatinib, nilotinib and dasatinib may have therapeutic implications in a number of inflammatory, fibrotic and neoplastic diseases." @default.
• W2011852093 created "2016-06-24" @default.
• W2011852093 creator A5013829081 @default.
• W2011852093 creator A5017218928 @default.
• W2011852093 creator A5018547546 @default.
• W2011852093 creator A5031680336 @default.
• W2011852093 creator A5042246504 @default.
• W2011852093 creator A5043208437 @default.
• W2011852093 creator A5076105990 @default.
• W2011852093 creator A5083068452 @default.
• W2011852093 date "2008-12-01" @default.
• W2011852093 modified "2023-10-16" @default.
• W2011852093 title "Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib" @default.
• W2011852093 cites W1592523365 @default.
• W2011852093 cites W1643419429 @default.
• W2011852093 cites W1959064417 @default.
• W2011852093 cites W1979107490 @default.
• W2011852093 cites W1986139301 @default.
• W2011852093 cites W2008952509 @default.
• W2011852093 cites W2012238745 @default.
• W2011852093 cites W2015616444 @default.
• W2011852093 cites W2019161121 @default.
• W2011852093 cites W2026542427 @default.
• W2011852093 cites W2029795839 @default.
• W2011852093 cites W2040291225 @default.
• W2011852093 cites W2040553138 @default.
• W2011852093 cites W2056622112 @default.
• W2011852093 cites W2065283382 @default.
• W2011852093 cites W2092606584 @default.
• W2011852093 cites W2093784914 @default.
• W2011852093 cites W2093905548 @default.
• W2011852093 cites W2095745765 @default.
• W2011852093 cites W2096495474 @default.
• W2011852093 cites W2101083650 @default.
• W2011852093 cites W2110689814 @default.
• W2011852093 cites W2124196948 @default.
• W2011852093 cites W2130886591 @default.
• W2011852093 cites W2131476854 @default.
• W2011852093 cites W2150647358 @default.
• W2011852093 cites W2154437955 @default.
• W2011852093 cites W4236147141 @default.
• W2011852093 cites W4243874817 @default.
• W2011852093 cites W4255779404 @default.
• W2011852093 doi "https://doi.org/10.1016/j.ejphar.2008.10.014" @default.
• W2011852093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18938156" @default.
• W2011852093 hasPublicationYear "2008" @default.
• W2011852093 type Work @default.
• W2011852093 sameAs 2011852093 @default.
• W2011852093 citedByCount "239" @default.
• W2011852093 countsByYear W20118520932012 @default.
• W2011852093 countsByYear W20118520932013 @default.
• W2011852093 countsByYear W20118520932014 @default.
• W2011852093 countsByYear W20118520932015 @default.
• W2011852093 countsByYear W20118520932016 @default.
• W2011852093 countsByYear W20118520932017 @default.
• W2011852093 countsByYear W20118520932018 @default.
• W2011852093 countsByYear W20118520932019 @default.
• W2011852093 countsByYear W20118520932020 @default.
• W2011852093 countsByYear W20118520932021 @default.
• W2011852093 countsByYear W20118520932022 @default.
• W2011852093 countsByYear W20118520932023 @default.
• W2011852093 crossrefType "journal-article" @default.
• W2011852093 hasAuthorship W2011852093A5013829081 @default.
• W2011852093 hasAuthorship W2011852093A5017218928 @default.
• W2011852093 hasAuthorship W2011852093A5018547546 @default.
• W2011852093 hasAuthorship W2011852093A5031680336 @default.
• W2011852093 hasAuthorship W2011852093A5042246504 @default.
• W2011852093 hasAuthorship W2011852093A5043208437 @default.
• W2011852093 hasAuthorship W2011852093A5076105990 @default.
• W2011852093 hasAuthorship W2011852093A5083068452 @default.
• W2011852093 hasConcept C101544691 @default.
• W2011852093 hasConcept C108636557 @default.
• W2011852093 hasConcept C152681006 @default.
• W2011852093 hasConcept C170493617 @default.
• W2011852093 hasConcept C175818844 @default.
• W2011852093 hasConcept C180361614 @default.
• W2011852093 hasConcept C184235292 @default.
• W2011852093 hasConcept C185592680 @default.
• W2011852093 hasConcept C2775960820 @default.
• W2011852093 hasConcept C2776305115 @default.
• W2011852093 hasConcept C2777413986 @default.
• W2011852093 hasConcept C2777583451 @default.
• W2011852093 hasConcept C2778729363 @default.
• W2011852093 hasConcept C2779536868 @default.
• W2011852093 hasConcept C42362537 @default.
• W2011852093 hasConcept C502942594 @default.
• W2011852093 hasConcept C55493867 @default.
• W2011852093 hasConcept C59143045 @default.
• W2011852093 hasConcept C62478195 @default.
• W2011852093 hasConcept C86803240 @default.
• W2011852093 hasConcept C90934575 @default.
• W2011852093 hasConcept C97029542 @default.
• W2011852093 hasConceptScore W2011852093C101544691 @default.
• W2011852093 hasConceptScore W2011852093C108636557 @default.
• W2011852093 hasConceptScore W2011852093C152681006 @default.
• W2011852093 hasConceptScore W2011852093C170493617 @default.
• W2011852093 hasConceptScore W2011852093C175818844 @default.
• W2011852093 hasConceptScore W2011852093C180361614 @default.

• next