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- W2011856273 abstract "We have previously shown that activation of the phosphatidyl-inositol/phospholipase C pathway could induce interleukin 6 (IL-6) release from U373MG human astrocytoma cells. We also found that, although interleukin 1β (IL-1β) did not activate phosphatidylinositol turnover, it induced a robust release of IL-6. In the present study, we examined the role of adenylate cyclase/cyclic 3′,5′-adenosine monophosphate (cAMP) pathway in IL-6 release. Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. On the other hand, in spite of its robust action on IL-6 release, IL-1β did not stimulate cAMP formation. Other possible signal transduction mechanisms involved in IL-1β-induced IL-6 release are discussed." @default.
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- W2011856273 date "1994-09-01" @default.
- W2011856273 modified "2023-10-14" @default.
- W2011856273 title "cAMP is not involved in interleukin-1-induced interleukin-6 release from human astrocytoma cells" @default.
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- W2011856273 doi "https://doi.org/10.1016/0304-3940(94)90771-4" @default.
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