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• W2011857098 abstract "Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally downregulates the low-density lipoprotein receptor (LDLR) by binding to the receptor's epidermal growth factor repeat A on the cell surface and shuttling the LDLR to the lysosomes for degradation. Mutations in the PCSK9 gene have been shown to cause either hypo- or hypercholesterolemia. Here we investigated the effect of berberine, a natural plant extract, on PCSK9 expression in HepG2 cells.Berberine decreases PCSK9 mRNA and protein levels in a time- and dose-dependent manner. This was not due to increased degradation of PCSK9 mRNA but most likely due to a decreased transcription of the PCSK9 gene. We also show that a combination of berberine and mevastatin increases LDLR mRNA and protein levels, while suppressing the increase in PCSK9 mRNA levels caused by mevastatin alone.Berberine may be a useful supplement to statin treatment due to its effects on PCSK9 mRNA and protein levels." @default.
• W2011857098 created "2016-06-24" @default.
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• W2011857098 date "2008-12-01" @default.
• W2011857098 modified "2023-10-02" @default.
• W2011857098 title "Berberine decreases PCSK9 expression in HepG2 cells" @default.
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• W2011857098 doi "https://doi.org/10.1016/j.atherosclerosis.2008.02.004" @default.
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