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- W2011858910 abstract "Elucidating the underlying genetic variations influencing various complex diseases is one of the major challenges currently facing clinical genetic research. Although these variations are often difficult to uncover, approaches such as genome-wide association studies (GWASs) have been successful at finding statistically significant associations between specific genomic loci and disease susceptibility. GWAS has been especially successful in elucidating genetic variants that influence type 2 diabetes (T2D) and obesity/body mass index (BMI). Specifically, several GWASs have confirmed that a variant in transcription factor 7-like 2 ( TCF7L2 ) confers risk for T2D, while a variant in fat mass and obesity-associated protein ( FTO ) confers risk for obesity/BMI; indeed both of these signals are considered the most statistically associated loci discovered for these respective traits to date. The discovery of these two key loci in this context has been invaluable for providing novel insight into mechanisms of heritability and disease pathogenesis. As follow-up studies of TCF7L2 and FTO have typically lead the way in how to follow up a GWAS discovery, we outline what has been learned from such investigations and how they have implications for the myriad of other loci that have been subsequently reported in this disease context." @default.
- W2011858910 created "2016-06-24" @default.
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- W2011858910 creator A5033787308 @default.
- W2011858910 creator A5069461209 @default.
- W2011858910 creator A5081417568 @default.
- W2011858910 date "2014-01-01" @default.
- W2011858910 modified "2023-10-16" @default.
- W2011858910 title "Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies" @default.
- W2011858910 cites W1485161311 @default.
- W2011858910 cites W1554815317 @default.
- W2011858910 cites W1602867585 @default.
- W2011858910 cites W1617586841 @default.
- W2011858910 cites W1937192900 @default.
- W2011858910 cites W1944558458 @default.
- W2011858910 cites W1963527044 @default.
- W2011858910 cites W1965141016 @default.
- W2011858910 cites W1965732593 @default.
- W2011858910 cites W1965929705 @default.
- W2011858910 cites W1966650637 @default.
- W2011858910 cites W1971751459 @default.
- W2011858910 cites W1976729219 @default.
- W2011858910 cites W1977118015 @default.
- W2011858910 cites W1978025245 @default.
- W2011858910 cites W1978215768 @default.
- W2011858910 cites W1983800470 @default.
- W2011858910 cites W1989970381 @default.
- W2011858910 cites W1991450386 @default.
- W2011858910 cites W1998422450 @default.
- W2011858910 cites W2000522513 @default.
- W2011858910 cites W2002404925 @default.
- W2011858910 cites W2002848248 @default.
- W2011858910 cites W2005722181 @default.
- W2011858910 cites W2006171501 @default.
- W2011858910 cites W2008599922 @default.
- W2011858910 cites W2013317847 @default.
- W2011858910 cites W2014077667 @default.
- W2011858910 cites W2014489310 @default.
- W2011858910 cites W2014679781 @default.
- W2011858910 cites W2024108088 @default.
- W2011858910 cites W2024670158 @default.
- W2011858910 cites W2025143098 @default.
- W2011858910 cites W2028335133 @default.
- W2011858910 cites W2029584069 @default.
- W2011858910 cites W2031539362 @default.
- W2011858910 cites W2032714982 @default.
- W2011858910 cites W2034286713 @default.
- W2011858910 cites W2034820020 @default.
- W2011858910 cites W2036990611 @default.
- W2011858910 cites W2043785033 @default.
- W2011858910 cites W2044518560 @default.
- W2011858910 cites W2045017910 @default.
- W2011858910 cites W2046503553 @default.
- W2011858910 cites W2047200356 @default.
- W2011858910 cites W2047565527 @default.
- W2011858910 cites W2048755332 @default.
- W2011858910 cites W2058401000 @default.
- W2011858910 cites W2059588512 @default.
- W2011858910 cites W2059867286 @default.
- W2011858910 cites W2060270800 @default.
- W2011858910 cites W2060913290 @default.
- W2011858910 cites W2062712171 @default.
- W2011858910 cites W2062886649 @default.
- W2011858910 cites W2065817368 @default.
- W2011858910 cites W2067387842 @default.
- W2011858910 cites W2068201869 @default.
- W2011858910 cites W2068989676 @default.
- W2011858910 cites W2069599670 @default.
- W2011858910 cites W2073079894 @default.
- W2011858910 cites W2075221196 @default.
- W2011858910 cites W2078050848 @default.
- W2011858910 cites W2078591745 @default.
- W2011858910 cites W2080680262 @default.
- W2011858910 cites W2082122713 @default.
- W2011858910 cites W2082793267 @default.
- W2011858910 cites W2083694904 @default.
- W2011858910 cites W2087104293 @default.
- W2011858910 cites W2090290755 @default.
- W2011858910 cites W2092207134 @default.
- W2011858910 cites W2094586902 @default.
- W2011858910 cites W2096969016 @default.
- W2011858910 cites W2097660065 @default.
- W2011858910 cites W2097843904 @default.
- W2011858910 cites W2098363135 @default.
- W2011858910 cites W2098715726 @default.
- W2011858910 cites W2100897696 @default.
- W2011858910 cites W2101359494 @default.
- W2011858910 cites W2102743706 @default.
- W2011858910 cites W2104458426 @default.
- W2011858910 cites W2106371330 @default.
- W2011858910 cites W2106689948 @default.
- W2011858910 cites W2106815400 @default.
- W2011858910 cites W2108932731 @default.
- W2011858910 cites W2110678911 @default.
- W2011858910 cites W2114687295 @default.
- W2011858910 cites W2117053787 @default.
- W2011858910 cites W2117602563 @default.
- W2011858910 cites W2119445047 @default.