Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011873455> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2011873455 endingPage "926" @default.
- W2011873455 startingPage "921" @default.
- W2011873455 abstract "We have studied the increase of vascular permeability produced by kinins in rabbit dermis using the measurement of the exudation of a protein-bound dye (Evans blue) following the local injections of peptides.Representatives of four peptide groups having kinin-like pharmacological properties have been tested in this system at doses ranging from 10 −12 to 10 −9 mol: they are bradykinin (BK), substance P, bombesin, and the C-terminal octapeptide of cholecystokinin. Only BK has appreciable effects at the utilised doses.In order to identify the type of receptor mediating the effect of kinins in this system, the following order of potency of agonist analogues has been measured: [Tyr(Me) 8 ]-BK > kallidin (KD) > BK > des-Arg 9 -BK. Moreover the B 1 receptor antagonist, des-Arg 10 -[Leu 9 ]-KD, was found to be inactive as inhibitor of the increase of permeability produced by BK. These facts suggest that bradykinin may activate B 2 receptors in this system.In order to assess the participation of other endogenous mediators to the effect of BK on vascular permeability, mixed solutions of BK and indomethacin or BK and mepyramine were injected in the rabbit dermis. Indomethacin (0,1 – 1 μg) did not modify the responses to BK while mepyramine (10 μg) significantly reduced the effects of the lowest doses of BK. This finding was taken as an indication of the possible participation of tissue histamine to the increased vascular permeability evoked by BK. It is concluded that the blueing assay of the rabbit dermis is a distinctive system (a) which is specific for BK-related kinins, (b) in which the effects of BK may be mediated by B 2 receptors, and (c) in which the action of BK may be partially mediated by histamine but is probably not mediated by arachidonic acid metabolites." @default.
- W2011873455 created "2016-06-24" @default.
- W2011873455 creator A5052376623 @default.
- W2011873455 creator A5087629766 @default.
- W2011873455 creator A5089612117 @default.
- W2011873455 date "1981-09-01" @default.
- W2011873455 modified "2023-10-17" @default.
- W2011873455 title "Pharmacological characterization of the vascular permeability enhancing effects of kinins in the rabbit skin" @default.
- W2011873455 doi "https://doi.org/10.1139/y81-142" @default.
- W2011873455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6170409" @default.
- W2011873455 hasPublicationYear "1981" @default.
- W2011873455 type Work @default.
- W2011873455 sameAs 2011873455 @default.
- W2011873455 citedByCount "35" @default.
- W2011873455 crossrefType "journal-article" @default.
- W2011873455 hasAuthorship W2011873455A5052376623 @default.
- W2011873455 hasAuthorship W2011873455A5087629766 @default.
- W2011873455 hasAuthorship W2011873455A5089612117 @default.
- W2011873455 hasConcept C1122143 @default.
- W2011873455 hasConcept C113045295 @default.
- W2011873455 hasConcept C126322002 @default.
- W2011873455 hasConcept C134018914 @default.
- W2011873455 hasConcept C170493617 @default.
- W2011873455 hasConcept C185592680 @default.
- W2011873455 hasConcept C2776246183 @default.
- W2011873455 hasConcept C2776885963 @default.
- W2011873455 hasConcept C2777649898 @default.
- W2011873455 hasConcept C2778938600 @default.
- W2011873455 hasConcept C2779090179 @default.
- W2011873455 hasConcept C2779591629 @default.
- W2011873455 hasConcept C2779730486 @default.
- W2011873455 hasConcept C55493867 @default.
- W2011873455 hasConcept C71924100 @default.
- W2011873455 hasConcept C86803240 @default.
- W2011873455 hasConcept C98274493 @default.
- W2011873455 hasConceptScore W2011873455C1122143 @default.
- W2011873455 hasConceptScore W2011873455C113045295 @default.
- W2011873455 hasConceptScore W2011873455C126322002 @default.
- W2011873455 hasConceptScore W2011873455C134018914 @default.
- W2011873455 hasConceptScore W2011873455C170493617 @default.
- W2011873455 hasConceptScore W2011873455C185592680 @default.
- W2011873455 hasConceptScore W2011873455C2776246183 @default.
- W2011873455 hasConceptScore W2011873455C2776885963 @default.
- W2011873455 hasConceptScore W2011873455C2777649898 @default.
- W2011873455 hasConceptScore W2011873455C2778938600 @default.
- W2011873455 hasConceptScore W2011873455C2779090179 @default.
- W2011873455 hasConceptScore W2011873455C2779591629 @default.
- W2011873455 hasConceptScore W2011873455C2779730486 @default.
- W2011873455 hasConceptScore W2011873455C55493867 @default.
- W2011873455 hasConceptScore W2011873455C71924100 @default.
- W2011873455 hasConceptScore W2011873455C86803240 @default.
- W2011873455 hasConceptScore W2011873455C98274493 @default.
- W2011873455 hasIssue "9" @default.
- W2011873455 hasLocation W20118734551 @default.
- W2011873455 hasLocation W20118734552 @default.
- W2011873455 hasOpenAccess W2011873455 @default.
- W2011873455 hasPrimaryLocation W20118734551 @default.
- W2011873455 hasRelatedWork W1565137730 @default.
- W2011873455 hasRelatedWork W2000006593 @default.
- W2011873455 hasRelatedWork W2000106180 @default.
- W2011873455 hasRelatedWork W2005432427 @default.
- W2011873455 hasRelatedWork W2011873455 @default.
- W2011873455 hasRelatedWork W2022679334 @default.
- W2011873455 hasRelatedWork W2024876025 @default.
- W2011873455 hasRelatedWork W2053843797 @default.
- W2011873455 hasRelatedWork W2414540589 @default.
- W2011873455 hasRelatedWork W2418971404 @default.
- W2011873455 hasVolume "59" @default.
- W2011873455 isParatext "false" @default.
- W2011873455 isRetracted "false" @default.
- W2011873455 magId "2011873455" @default.
- W2011873455 workType "article" @default.