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- W2011875400 abstract "To identify changes in hepatic parenchymal volume, fibrosis and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Using standard 90Yttrium glass microspheres (TheraSphere, MDS Nordion) lobar treatment protocol, 32 patients (sequential bilobar treatments n=17, right lobe treatment n= 10, left lobe treatment n=5) received 90Yttrium infusions targeting 120 Gy to each lobe. We reviewed the pre and post-treatment imaging (CT, MRI) looking for changes in the right and left lobe volumes, whole liver and splenic volumes. In addition, main portal vein as well as left and right portal vein diameter measurements were also assessed pre and post treatments. In our series of sequential bilobar (n=17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n=15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2% and a 5.4% increase in portal vein diameter was also noted. These findings were not associated with clinical toxicities. 90Yttrium radioembolization, utilizing glass microspheres, in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of portal hypertension. Further studies assessing the long-term effects are warranted." @default.
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- W2011875400 date "2008-02-01" @default.
- W2011875400 modified "2023-10-17" @default.
- W2011875400 title "Abstract No. 217: Fibrosis, Portal Hypertension and Hepatic Volume Changes Induced by 90Yttrium Radioembolization" @default.
- W2011875400 doi "https://doi.org/10.1016/j.jvir.2007.12.241" @default.
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