FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011879423> ?p ?o ?g. }

• W2011879423 endingPage "609" @default.
• W2011879423 startingPage "604" @default.
• W2011879423 abstract "14,15-Epoxyeicosatrienoic acid (14,15-EET), a metabolite of arachidonic acid, is enriched in the brain cortex and exerts protective effect against neuronal apoptosis induced by ischemia/reperfusion. Although apoptosis has been well recognized to be closely associated with mitochondrial biogenesis and function, it is still unclear whether the neuroprotective effect of 14,15-EET is mediated by promotion of mitochondrial biogenesis and function in cortical neurons under the condition of oxygen–glucose deprivation (OGD). In this study, we found that 14,15-EET improved cell viability and inhibited apoptosis of cortical neurons. 14,15-EET significantly increased the mitochondrial mass and the ratio of mitochondrial DNA to nuclear DNA. Key makers of mitochondrial biogenesis, peroxisome proliferator activator receptor gamma-coactivator 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM), were elevated at both mRNA and protein levels in the cortical neurons treated with 14,15-EET. Moreover, 14,15-EET markedly attenuated the decline of mitochondrial membrane potential, reduced ROS, while increased ATP synthesis. Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1α and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. Our results indicate that 14,15-EET protects neurons from OGD-induced apoptosis by promoting mitochondrial biogenesis and function through CREB mediated activation of PGC-1α and NRF-1." @default.
• W2011879423 created "2016-06-24" @default.
• W2011879423 creator A5020700704 @default.
• W2011879423 creator A5026114666 @default.
• W2011879423 creator A5030513449 @default.
• W2011879423 creator A5032288905 @default.
• W2011879423 creator A5053222571 @default.
• W2011879423 creator A5067223991 @default.
• W2011879423 date "2014-07-01" @default.
• W2011879423 modified "2023-10-02" @default.
• W2011879423 title "14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis" @default.
• W2011879423 cites W1492293073 @default.
• W2011879423 cites W1928588989 @default.
• W2011879423 cites W1980772954 @default.
• W2011879423 cites W1988005040 @default.
• W2011879423 cites W2003833061 @default.
• W2011879423 cites W2004595433 @default.
• W2011879423 cites W2009271779 @default.
• W2011879423 cites W2012430016 @default.
• W2011879423 cites W2017253782 @default.
• W2011879423 cites W2019488837 @default.
• W2011879423 cites W2033368542 @default.
• W2011879423 cites W2040643662 @default.
• W2011879423 cites W2046858517 @default.
• W2011879423 cites W2067002833 @default.
• W2011879423 cites W2073274985 @default.
• W2011879423 cites W2081077857 @default.
• W2011879423 cites W2083736192 @default.
• W2011879423 cites W2112701033 @default.
• W2011879423 cites W2119559799 @default.
• W2011879423 cites W2127876602 @default.
• W2011879423 cites W2138076149 @default.
• W2011879423 cites W2140835204 @default.
• W2011879423 cites W2149249593 @default.
• W2011879423 cites W2149675148 @default.
• W2011879423 cites W2150687686 @default.
• W2011879423 cites W2155337367 @default.
• W2011879423 doi "https://doi.org/10.1016/j.bbrc.2014.06.022" @default.
• W2011879423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24931672" @default.
• W2011879423 hasPublicationYear "2014" @default.
• W2011879423 type Work @default.
• W2011879423 sameAs 2011879423 @default.
• W2011879423 citedByCount "35" @default.
• W2011879423 countsByYear W20118794232015 @default.
• W2011879423 countsByYear W20118794232016 @default.
• W2011879423 countsByYear W20118794232017 @default.
• W2011879423 countsByYear W20118794232018 @default.
• W2011879423 countsByYear W20118794232019 @default.
• W2011879423 countsByYear W20118794232020 @default.
• W2011879423 countsByYear W20118794232021 @default.
• W2011879423 countsByYear W20118794232022 @default.
• W2011879423 countsByYear W20118794232023 @default.
• W2011879423 crossrefType "journal-article" @default.
• W2011879423 hasAuthorship W2011879423A5020700704 @default.
• W2011879423 hasAuthorship W2011879423A5026114666 @default.
• W2011879423 hasAuthorship W2011879423A5030513449 @default.
• W2011879423 hasAuthorship W2011879423A5032288905 @default.
• W2011879423 hasAuthorship W2011879423A5053222571 @default.
• W2011879423 hasAuthorship W2011879423A5067223991 @default.
• W2011879423 hasConcept C104317684 @default.
• W2011879423 hasConcept C1629964 @default.
• W2011879423 hasConcept C169415338 @default.
• W2011879423 hasConcept C173358068 @default.
• W2011879423 hasConcept C185592680 @default.
• W2011879423 hasConcept C190283241 @default.
• W2011879423 hasConcept C25498285 @default.
• W2011879423 hasConcept C2777229759 @default.
• W2011879423 hasConcept C28859421 @default.
• W2011879423 hasConcept C55493867 @default.
• W2011879423 hasConcept C74438686 @default.
• W2011879423 hasConcept C75385678 @default.
• W2011879423 hasConcept C77445288 @default.
• W2011879423 hasConcept C86339819 @default.
• W2011879423 hasConcept C86803240 @default.
• W2011879423 hasConcept C95444343 @default.
• W2011879423 hasConcept C98274493 @default.
• W2011879423 hasConceptScore W2011879423C104317684 @default.
• W2011879423 hasConceptScore W2011879423C1629964 @default.
• W2011879423 hasConceptScore W2011879423C169415338 @default.
• W2011879423 hasConceptScore W2011879423C173358068 @default.
• W2011879423 hasConceptScore W2011879423C185592680 @default.
• W2011879423 hasConceptScore W2011879423C190283241 @default.
• W2011879423 hasConceptScore W2011879423C25498285 @default.
• W2011879423 hasConceptScore W2011879423C2777229759 @default.
• W2011879423 hasConceptScore W2011879423C28859421 @default.
• W2011879423 hasConceptScore W2011879423C55493867 @default.
• W2011879423 hasConceptScore W2011879423C74438686 @default.
• W2011879423 hasConceptScore W2011879423C75385678 @default.
• W2011879423 hasConceptScore W2011879423C77445288 @default.
• W2011879423 hasConceptScore W2011879423C86339819 @default.
• W2011879423 hasConceptScore W2011879423C86803240 @default.
• W2011879423 hasConceptScore W2011879423C95444343 @default.
• W2011879423 hasConceptScore W2011879423C98274493 @default.
• W2011879423 hasFunder F4320321001 @default.
• W2011879423 hasIssue "1" @default.
• W2011879423 hasLocation W20118794231 @default.
• W2011879423 hasLocation W20118794232 @default.
• W2011879423 hasOpenAccess W2011879423 @default.

• next