FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011881034> ?p ?o ?g. }

• W2011881034 endingPage "11549" @default.
• W2011881034 startingPage "11540" @default.
• W2011881034 abstract "The human safety aspects of seafood production require the expansion of vital knowledge of both nutrients and possible contaminants along the entire production chain. Thus, production of safer seafood can be achieved by using feed materials that are low in contaminants, while maintaining balanced nutrition, in order to secure optimal fish and consumer health. Our understanding of primary responses of fish health and production related diseases, as well as biological processes that influence carry-over and lowering of contaminants in farmed fish, will contribute to a sustainable production of safer seafood products. Therefore, we have studied the liver deposition and toxicological effects in salmon fed graded levels of BHT during a 12-week feeding followed by a 2-week depuration period using chemical, molecular, and catalytic assays. In general, our data showed that BHT was significantly retained in the liver and selectively modulated toxicological responses in the xenobiotic biotransformation pathways during the feeding period. Specifically, BHT produced consistent dose- and time-specific gene expression patterns for AhR2α, AhR2β, CYP1A1, CYP3A, UGT1, and GSTπ. The effect of BHT on the gene expression of biotransformation enzyme did not parallel enzyme activity levels, suggesting a possible inhibition by parent BHT or its metabolites. As a safety precaution, the production of farmed Atlantic salmon in Norway requires a mandatory 2-week depuration period prior to slaughtering and market delivery to ensure the elimination of veterinary medicaments, additives, and other undesirable components. Comparison of feeding and depuration periods showed that BHT was highly retained in fish liver, as only 8−13% of fed BHT was eliminated during the 2-week depuration period. This is just a part of the total concentration in the whole fish, since BHT may have been distributed and accumulated in other organs. Since BHT or its metabolites putatively inhibited biotransformation enzymes and affected metabolism of the compound, they may have potential for toxicological and adverse health effects for both fish and fish consumers through carry-over processes from the fish products." @default.
• W2011881034 created "2016-06-24" @default.
• W2011881034 creator A5010251955 @default.
• W2011881034 creator A5029156713 @default.
• W2011881034 creator A5083366862 @default.
• W2011881034 creator A5085320289 @default.
• W2011881034 date "2008-11-13" @default.
• W2011881034 modified "2023-10-16" @default.
• W2011881034 title "Hepatic Retention and Toxicological Responses during Feeding and Depuration Periods in Atlantic Salmon (Salmo salar) Fed Graded Levels of the Synthetic Antioxidant, Butylated Hydroxytoluene" @default.
• W2011881034 cites W1483062858 @default.
• W2011881034 cites W148705138 @default.
• W2011881034 cites W1581414347 @default.
• W2011881034 cites W1964045671 @default.
• W2011881034 cites W1964961036 @default.
• W2011881034 cites W1968124397 @default.
• W2011881034 cites W1968538313 @default.
• W2011881034 cites W1968906511 @default.
• W2011881034 cites W1969904539 @default.
• W2011881034 cites W1972329958 @default.
• W2011881034 cites W1977667594 @default.
• W2011881034 cites W1995681117 @default.
• W2011881034 cites W1998183082 @default.
• W2011881034 cites W1998664328 @default.
• W2011881034 cites W1999364260 @default.
• W2011881034 cites W2006998778 @default.
• W2011881034 cites W2008071103 @default.
• W2011881034 cites W2009226355 @default.
• W2011881034 cites W2017750872 @default.
• W2011881034 cites W2020053289 @default.
• W2011881034 cites W2020487253 @default.
• W2011881034 cites W2020650111 @default.
• W2011881034 cites W2023877360 @default.
• W2011881034 cites W2034276577 @default.
• W2011881034 cites W2038747660 @default.
• W2011881034 cites W2042821693 @default.
• W2011881034 cites W2043349090 @default.
• W2011881034 cites W2043897851 @default.
• W2011881034 cites W2049656784 @default.
• W2011881034 cites W2053236035 @default.
• W2011881034 cites W2059201682 @default.
• W2011881034 cites W2061098170 @default.
• W2011881034 cites W2066439231 @default.
• W2011881034 cites W2069178739 @default.
• W2011881034 cites W2075266560 @default.
• W2011881034 cites W2082193181 @default.
• W2011881034 cites W2084687829 @default.
• W2011881034 cites W2097348395 @default.
• W2011881034 cites W2110480967 @default.
• W2011881034 cites W2117517965 @default.
• W2011881034 cites W2126921546 @default.
• W2011881034 cites W2144062280 @default.
• W2011881034 cites W2154494669 @default.
• W2011881034 cites W2162909529 @default.
• W2011881034 cites W2208117931 @default.
• W2011881034 cites W2322620650 @default.
• W2011881034 cites W2415186660 @default.
• W2011881034 cites W4293247451 @default.
• W2011881034 doi "https://doi.org/10.1021/jf8025524" @default.
• W2011881034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19007167" @default.
• W2011881034 hasPublicationYear "2008" @default.
• W2011881034 type Work @default.
• W2011881034 sameAs 2011881034 @default.
• W2011881034 citedByCount "17" @default.
• W2011881034 countsByYear W20118810342012 @default.
• W2011881034 countsByYear W20118810342013 @default.
• W2011881034 countsByYear W20118810342014 @default.
• W2011881034 countsByYear W20118810342015 @default.
• W2011881034 countsByYear W20118810342020 @default.
• W2011881034 countsByYear W20118810342022 @default.
• W2011881034 countsByYear W20118810342023 @default.
• W2011881034 crossrefType "journal-article" @default.
• W2011881034 hasAuthorship W2011881034A5010251955 @default.
• W2011881034 hasAuthorship W2011881034A5029156713 @default.
• W2011881034 hasAuthorship W2011881034A5083366862 @default.
• W2011881034 hasAuthorship W2011881034A5085320289 @default.
• W2011881034 hasConcept C181199279 @default.
• W2011881034 hasConcept C185592680 @default.
• W2011881034 hasConcept C2777940460 @default.
• W2011881034 hasConcept C2778004101 @default.
• W2011881034 hasConcept C2779661893 @default.
• W2011881034 hasConcept C27881333 @default.
• W2011881034 hasConcept C2909208804 @default.
• W2011881034 hasConcept C31903555 @default.
• W2011881034 hasConcept C505870484 @default.
• W2011881034 hasConcept C55493867 @default.
• W2011881034 hasConcept C86803240 @default.
• W2011881034 hasConceptScore W2011881034C181199279 @default.
• W2011881034 hasConceptScore W2011881034C185592680 @default.
• W2011881034 hasConceptScore W2011881034C2777940460 @default.
• W2011881034 hasConceptScore W2011881034C2778004101 @default.
• W2011881034 hasConceptScore W2011881034C2779661893 @default.
• W2011881034 hasConceptScore W2011881034C27881333 @default.
• W2011881034 hasConceptScore W2011881034C2909208804 @default.
• W2011881034 hasConceptScore W2011881034C31903555 @default.
• W2011881034 hasConceptScore W2011881034C505870484 @default.
• W2011881034 hasConceptScore W2011881034C55493867 @default.
• W2011881034 hasConceptScore W2011881034C86803240 @default.
• W2011881034 hasIssue "23" @default.

• next