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• W2011882003 abstract "A comparative bioavailability study was carried out in rabbits on pure powder of norfloxacin and its formulations: aqueous solution, polyethyleneglycol 6000 solid dispersions (PEG 6000 SD), beta-cyclodextrin (β-CD) and hydroxy-propyl-beta cyclodextrin (HP-β-CD) complexes. Norfloxacin plasma concentrations were measured by HPLC method with a fluorimetric detection. Estimation of t12 and ke proved that PEG 6000 SD and CD complexes did not modify the elimination characteristics of norfloxacin. Data from plasma concentration profiles indicated that absorption of norfloxacin from of SD and inclusion complexes was markedly accelerated when compared with powder of pure drug. The extent of absorption was significantly smaller with powder of norfloxacin than with its formulations. Bioavailability was improved and significantly higher with CD and complexes SD than with powder, but the improvement was lower than expected." @default.
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• W2011882003 date "1996-04-01" @default.
• W2011882003 modified "2023-10-14" @default.
• W2011882003 title "Bioavailability of norfloxacin from PEG 6000 solid dispersion and cyclodextrin inclusion complexes in rabbits" @default.
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• W2011882003 doi "https://doi.org/10.1016/0378-5173(95)04387-x" @default.
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