Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011884125> ?p ?o ?g. }
- W2011884125 endingPage "790" @default.
- W2011884125 startingPage "781" @default.
- W2011884125 abstract "The role of p38 and c-jun-N-terminal kinases 1/2, members of the mitogen-activated protein kinase family, in mediating the toxic effects of human immunodeficiency virus-1 transactivator of transcription (Tat) and gp120 were explored in primary mouse striatal neurons in vitro. Both Tat and gp120 caused significant increases in p38 and c-jun-N-terminal kinase mitogen-activated protein kinase phosphorylation, caspase-3 activity, neurite losses and cell death in striatal neurons. Tat-induced increases in caspase-3 activity were significantly attenuated by an inhibitor of c-jun-N-terminal kinase (anthra[1,9-cd]pyrazol-6(2H)-one), but not by an inhibitor of p38 ([4-(4-fluorophenyl)-2-(4-methylsul-finylphenyl)-5-(4-pyridyl)1 H-imidazole]), mitogen-activated protein kinase. However, despite preventing increases in caspase-3 activity, c-jun-N-terminal kinase inhibition failed to avert Tat-induced neuronal losses suggesting that the reductions in caspase-3 activity were insufficient to prevent cell death caused by Tat. Alternatively, gp120-induced increases in caspase-3 activity, neurite losses and neuronal death were prevented by p38, but not c-jun-N-terminal kinase, mitogen-activated protein kinase inhibition. Our findings suggest that gp120 induces neuronal dysfunction and death through actions at p38 mitogen-activated protein kinase, while Tat kills neurons through actions that are independent of p38 or c-jun-N-terminal kinase mitogen-activated protein kinase, or through the concurrent activation of multiple proapoptotic pathways." @default.
- W2011884125 created "2016-06-24" @default.
- W2011884125 creator A5000097172 @default.
- W2011884125 creator A5000297941 @default.
- W2011884125 creator A5006785320 @default.
- W2011884125 creator A5018617711 @default.
- W2011884125 creator A5026701884 @default.
- W2011884125 creator A5047920678 @default.
- W2011884125 creator A5076458805 @default.
- W2011884125 date "2005-01-01" @default.
- W2011884125 modified "2023-10-16" @default.
- W2011884125 title "Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons" @default.
- W2011884125 cites W1497318553 @default.
- W2011884125 cites W1539290896 @default.
- W2011884125 cites W1598531361 @default.
- W2011884125 cites W1603429964 @default.
- W2011884125 cites W1883860207 @default.
- W2011884125 cites W1909901392 @default.
- W2011884125 cites W1915946375 @default.
- W2011884125 cites W1965786497 @default.
- W2011884125 cites W1966720944 @default.
- W2011884125 cites W1970203334 @default.
- W2011884125 cites W1979814082 @default.
- W2011884125 cites W1987559348 @default.
- W2011884125 cites W1990083135 @default.
- W2011884125 cites W1993182734 @default.
- W2011884125 cites W1993812737 @default.
- W2011884125 cites W1996768398 @default.
- W2011884125 cites W1998529637 @default.
- W2011884125 cites W2003098831 @default.
- W2011884125 cites W2017239109 @default.
- W2011884125 cites W2018421706 @default.
- W2011884125 cites W2018877420 @default.
- W2011884125 cites W2026894807 @default.
- W2011884125 cites W2027433436 @default.
- W2011884125 cites W2034184306 @default.
- W2011884125 cites W2035418780 @default.
- W2011884125 cites W2035618690 @default.
- W2011884125 cites W2037156529 @default.
- W2011884125 cites W2043301085 @default.
- W2011884125 cites W2043315694 @default.
- W2011884125 cites W2044177663 @default.
- W2011884125 cites W2044975828 @default.
- W2011884125 cites W2046157554 @default.
- W2011884125 cites W2047261761 @default.
- W2011884125 cites W2049384855 @default.
- W2011884125 cites W2052305221 @default.
- W2011884125 cites W2052388575 @default.
- W2011884125 cites W2052543965 @default.
- W2011884125 cites W2064039123 @default.
- W2011884125 cites W2067380183 @default.
- W2011884125 cites W2067545369 @default.
- W2011884125 cites W2067550112 @default.
- W2011884125 cites W2070529844 @default.
- W2011884125 cites W2072521261 @default.
- W2011884125 cites W2073829834 @default.
- W2011884125 cites W2076485183 @default.
- W2011884125 cites W2081656164 @default.
- W2011884125 cites W2084687782 @default.
- W2011884125 cites W2089286762 @default.
- W2011884125 cites W2099080968 @default.
- W2011884125 cites W2103575089 @default.
- W2011884125 cites W2107022871 @default.
- W2011884125 cites W2113613483 @default.
- W2011884125 cites W2120658132 @default.
- W2011884125 cites W2126009035 @default.
- W2011884125 cites W2138902434 @default.
- W2011884125 cites W2140675537 @default.
- W2011884125 cites W2141510469 @default.
- W2011884125 cites W2147151936 @default.
- W2011884125 cites W2169241566 @default.
- W2011884125 cites W2279313673 @default.
- W2011884125 cites W2323124509 @default.
- W2011884125 cites W2327820825 @default.
- W2011884125 cites W2418386747 @default.
- W2011884125 cites W2790805946 @default.
- W2011884125 cites W321625949 @default.
- W2011884125 cites W1625890731 @default.
- W2011884125 doi "https://doi.org/10.1016/j.neuroscience.2005.05.028" @default.
- W2011884125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4310730" @default.
- W2011884125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16111829" @default.
- W2011884125 hasPublicationYear "2005" @default.
- W2011884125 type Work @default.
- W2011884125 sameAs 2011884125 @default.
- W2011884125 citedByCount "69" @default.
- W2011884125 countsByYear W20118841252012 @default.
- W2011884125 countsByYear W20118841252013 @default.
- W2011884125 countsByYear W20118841252014 @default.
- W2011884125 countsByYear W20118841252015 @default.
- W2011884125 countsByYear W20118841252016 @default.
- W2011884125 countsByYear W20118841252017 @default.
- W2011884125 countsByYear W20118841252018 @default.
- W2011884125 countsByYear W20118841252019 @default.
- W2011884125 countsByYear W20118841252020 @default.
- W2011884125 countsByYear W20118841252021 @default.
- W2011884125 crossrefType "journal-article" @default.
- W2011884125 hasAuthorship W2011884125A5000097172 @default.
- W2011884125 hasAuthorship W2011884125A5000297941 @default.