Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011890312> ?p ?o ?g. }
- W2011890312 endingPage "76" @default.
- W2011890312 startingPage "67" @default.
- W2011890312 abstract "Urocortin 2 (Ucn 2) is a corticotrop releasing factor paralog peptide with many physiological functions and it has widespread distribution. There are some data on the cytoprotective effects of Ucn 2, but less is known about its neuro- and retinoprotective actions. We have previously shown that Ucn 2 is protective in ischemia-induced retinal degeneration. The aim of the present study was to examine the protective potential of Ucn 2 in monosodium-glutamate (MSG)-induced retinal degeneration by routine histology and to investigate cell-type specific effects by immunohistochemistry. Rat pups received MSG applied on postnatal days 1, 5 and 9 and Ucn 2 was injected intravitreally into one eye. Retinas were processed for histology and immunocytochemistry after 3 weeks. Immunolabeling was determined for glial fibrillary acidic protein, vesicular glutamate transporter 1, protein kinase Cα, calbindin, parvalbumin and calretinin. Retinal tissue from animals treated with MSG showed severe degeneration compared to normal retinas, but intravitreal Ucn 2 treatment resulted in a retained retinal structure both at histological and neurochemical levels: distinct inner retinal layers and rescued inner retinal cells (different types of amacrine and rod bipolar cells) could be observed. These findings support the neuroprotective function of Ucn 2 in MSG-induced retinal degeneration." @default.
- W2011890312 created "2016-06-24" @default.
- W2011890312 creator A5005880385 @default.
- W2011890312 creator A5012145031 @default.
- W2011890312 creator A5015188454 @default.
- W2011890312 creator A5021620321 @default.
- W2011890312 creator A5032952822 @default.
- W2011890312 creator A5038780695 @default.
- W2011890312 creator A5057220825 @default.
- W2011890312 creator A5068138460 @default.
- W2011890312 date "2014-03-01" @default.
- W2011890312 modified "2023-10-16" @default.
- W2011890312 title "Urocortin 2 treatment is protective in excitotoxic retinal degeneration" @default.
- W2011890312 cites W1966577838 @default.
- W2011890312 cites W1967597145 @default.
- W2011890312 cites W1980447378 @default.
- W2011890312 cites W1982023576 @default.
- W2011890312 cites W1982422365 @default.
- W2011890312 cites W1982867177 @default.
- W2011890312 cites W1985070835 @default.
- W2011890312 cites W1997029554 @default.
- W2011890312 cites W2002102558 @default.
- W2011890312 cites W2008833406 @default.
- W2011890312 cites W2013432169 @default.
- W2011890312 cites W2017317142 @default.
- W2011890312 cites W2019851028 @default.
- W2011890312 cites W2020285808 @default.
- W2011890312 cites W2021160835 @default.
- W2011890312 cites W2026561698 @default.
- W2011890312 cites W2031241029 @default.
- W2011890312 cites W2031385222 @default.
- W2011890312 cites W2035437410 @default.
- W2011890312 cites W2040550641 @default.
- W2011890312 cites W2046013541 @default.
- W2011890312 cites W2049760844 @default.
- W2011890312 cites W2055926767 @default.
- W2011890312 cites W2059306365 @default.
- W2011890312 cites W2072495302 @default.
- W2011890312 cites W2086332753 @default.
- W2011890312 cites W2089037015 @default.
- W2011890312 cites W2094654990 @default.
- W2011890312 cites W2094853228 @default.
- W2011890312 cites W2095262579 @default.
- W2011890312 cites W2095373200 @default.
- W2011890312 cites W2097758006 @default.
- W2011890312 cites W2099060458 @default.
- W2011890312 cites W2099161484 @default.
- W2011890312 cites W2111794244 @default.
- W2011890312 cites W2117576447 @default.
- W2011890312 cites W2119474636 @default.
- W2011890312 cites W2150290300 @default.
- W2011890312 cites W2164361371 @default.
- W2011890312 doi "https://doi.org/10.1556/aphysiol.100.2013.020" @default.
- W2011890312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24311224" @default.
- W2011890312 hasPublicationYear "2014" @default.
- W2011890312 type Work @default.
- W2011890312 sameAs 2011890312 @default.
- W2011890312 citedByCount "5" @default.
- W2011890312 countsByYear W20118903122014 @default.
- W2011890312 countsByYear W20118903122017 @default.
- W2011890312 countsByYear W20118903122018 @default.
- W2011890312 countsByYear W20118903122019 @default.
- W2011890312 countsByYear W20118903122022 @default.
- W2011890312 crossrefType "journal-article" @default.
- W2011890312 hasAuthorship W2011890312A5005880385 @default.
- W2011890312 hasAuthorship W2011890312A5012145031 @default.
- W2011890312 hasAuthorship W2011890312A5015188454 @default.
- W2011890312 hasAuthorship W2011890312A5021620321 @default.
- W2011890312 hasAuthorship W2011890312A5032952822 @default.
- W2011890312 hasAuthorship W2011890312A5038780695 @default.
- W2011890312 hasAuthorship W2011890312A5057220825 @default.
- W2011890312 hasAuthorship W2011890312A5068138460 @default.
- W2011890312 hasBestOaLocation W20118903122 @default.
- W2011890312 hasConcept C141547260 @default.
- W2011890312 hasConcept C142724271 @default.
- W2011890312 hasConcept C169760540 @default.
- W2011890312 hasConcept C170493617 @default.
- W2011890312 hasConcept C203014093 @default.
- W2011890312 hasConcept C204232928 @default.
- W2011890312 hasConcept C25498285 @default.
- W2011890312 hasConcept C26265296 @default.
- W2011890312 hasConcept C2776925932 @default.
- W2011890312 hasConcept C2777093970 @default.
- W2011890312 hasConcept C2777688879 @default.
- W2011890312 hasConcept C2779134260 @default.
- W2011890312 hasConcept C2780495277 @default.
- W2011890312 hasConcept C2780827179 @default.
- W2011890312 hasConcept C2781040256 @default.
- W2011890312 hasConcept C2781404787 @default.
- W2011890312 hasConcept C55493867 @default.
- W2011890312 hasConcept C71924100 @default.
- W2011890312 hasConcept C86803240 @default.
- W2011890312 hasConcept C95444343 @default.
- W2011890312 hasConceptScore W2011890312C141547260 @default.
- W2011890312 hasConceptScore W2011890312C142724271 @default.
- W2011890312 hasConceptScore W2011890312C169760540 @default.
- W2011890312 hasConceptScore W2011890312C170493617 @default.
- W2011890312 hasConceptScore W2011890312C203014093 @default.