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- W2011891100 endingPage "277" @default.
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- W2011891100 abstract "Abstract Huntington’s disease (HD) is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite extensive research, treatment options for patients with this condition remain limited. Aberrant post-translational modification (PTM) of proteins is emerging as an important element in the pathogenesis of HD. These PTMs include acetylation, phosphorylation, methylation, sumoylation and ubiquitination. Several families of proteins are involved with the regulation of these PTMs. In this review, I discuss the current evidence linking aberrant PTMs and/or aberrant regulation of the cellular machinery regulating these PTMs to HD pathogenesis. Finally, I discuss the evidence suggesting that pharmacologically targeting one of these protein families the histone deacetylases may be of potential therapeutic benefit in the treatment of HD." @default.
- W2011891100 created "2016-06-24" @default.
- W2011891100 creator A5038015402 @default.
- W2011891100 date "2011-02-18" @default.
- W2011891100 modified "2023-09-26" @default.
- W2011891100 title "Targeting Huntington’s disease through histone deacetylases" @default.
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