Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011892883> ?p ?o ?g. }
- W2011892883 endingPage "7932" @default.
- W2011892883 startingPage "7928" @default.
- W2011892883 abstract "One of the promises of modern molecular biology has been the opportunity to use genetically modified human cells in a patient to permanently restore inborn errors of metabolism. Although it has been possible to introduce genes into mammalian cells and to control their expression, it has proven difficult to introduce mammalian cells as carriers of the modified genetic information into hosts. The successful implantation of selective cells cannot be achieved without adequate vascular support, an essential step toward integration and reconstitution of a new biological function. Although a partial solution to this problem has been found by inducing specific site-directed neovessel formation using heparin-binding growth factor 1 (HBGF-1) adsorbed to a collagen matrix, these implants function for only a short period (weeks). We now report the formation of organoid neovascular structures using polytetrafluoroethylene fibers coated with collagen and HBGF-1 implanted in the peritoneal cavity of the rat. The organoid structures contained readily visible vascular lumina and nonvascular structures that resemble nerve tissue. It was also possible to demonstrate that the vascular system on the implant is continuous with the vascular tree of the host. This feature was used to demonstrate that the organoid structures are capable of sustaining the biological function of implanted normal rat hepatocytes over long periods of time (months) in the homozygous Gunn rat, thereby facilitating future applications involving the delivery of new genetic information." @default.
- W2011892883 created "2016-06-24" @default.
- W2011892883 creator A5004309725 @default.
- W2011892883 creator A5039937464 @default.
- W2011892883 creator A5061858226 @default.
- W2011892883 creator A5067238310 @default.
- W2011892883 creator A5073921549 @default.
- W2011892883 creator A5089860825 @default.
- W2011892883 date "1989-10-01" @default.
- W2011892883 modified "2023-10-03" @default.
- W2011892883 title "Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo." @default.
- W2011892883 cites W1510595339 @default.
- W2011892883 cites W163741303 @default.
- W2011892883 cites W1897866650 @default.
- W2011892883 cites W1929113408 @default.
- W2011892883 cites W1966182982 @default.
- W2011892883 cites W1969235095 @default.
- W2011892883 cites W1971671659 @default.
- W2011892883 cites W1972848255 @default.
- W2011892883 cites W1974491777 @default.
- W2011892883 cites W1975042363 @default.
- W2011892883 cites W1977311938 @default.
- W2011892883 cites W1977855377 @default.
- W2011892883 cites W1979546790 @default.
- W2011892883 cites W1980684612 @default.
- W2011892883 cites W1993790237 @default.
- W2011892883 cites W1999521250 @default.
- W2011892883 cites W2004995270 @default.
- W2011892883 cites W2011892883 @default.
- W2011892883 cites W2015648732 @default.
- W2011892883 cites W2023765303 @default.
- W2011892883 cites W2029943349 @default.
- W2011892883 cites W2032658333 @default.
- W2011892883 cites W2043300139 @default.
- W2011892883 cites W2045819735 @default.
- W2011892883 cites W2049042095 @default.
- W2011892883 cites W2049661577 @default.
- W2011892883 cites W2058153935 @default.
- W2011892883 cites W2060064462 @default.
- W2011892883 cites W2070039435 @default.
- W2011892883 cites W2072482644 @default.
- W2011892883 cites W2077578618 @default.
- W2011892883 cites W2088227793 @default.
- W2011892883 cites W2099543104 @default.
- W2011892883 cites W2110610344 @default.
- W2011892883 cites W2121119720 @default.
- W2011892883 cites W2132123006 @default.
- W2011892883 cites W2133685524 @default.
- W2011892883 cites W2145623185 @default.
- W2011892883 cites W2323600033 @default.
- W2011892883 cites W2416979810 @default.
- W2011892883 cites W2417302984 @default.
- W2011892883 cites W4255042798 @default.
- W2011892883 doi "https://doi.org/10.1073/pnas.86.20.7928" @default.
- W2011892883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/516803" @default.
- W2011892883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2479012" @default.
- W2011892883 hasPublicationYear "1989" @default.
- W2011892883 type Work @default.
- W2011892883 sameAs 2011892883 @default.
- W2011892883 citedByCount "125" @default.
- W2011892883 countsByYear W20118928832016 @default.
- W2011892883 countsByYear W20118928832019 @default.
- W2011892883 crossrefType "journal-article" @default.
- W2011892883 hasAuthorship W2011892883A5004309725 @default.
- W2011892883 hasAuthorship W2011892883A5039937464 @default.
- W2011892883 hasAuthorship W2011892883A5061858226 @default.
- W2011892883 hasAuthorship W2011892883A5067238310 @default.
- W2011892883 hasAuthorship W2011892883A5073921549 @default.
- W2011892883 hasAuthorship W2011892883A5089860825 @default.
- W2011892883 hasBestOaLocation W20118928831 @default.
- W2011892883 hasConcept C136229726 @default.
- W2011892883 hasConcept C141071460 @default.
- W2011892883 hasConcept C142724271 @default.
- W2011892883 hasConcept C170493617 @default.
- W2011892883 hasConcept C185592680 @default.
- W2011892883 hasConcept C207001950 @default.
- W2011892883 hasConcept C2775960820 @default.
- W2011892883 hasConcept C2777557582 @default.
- W2011892883 hasConcept C2781411149 @default.
- W2011892883 hasConcept C31695470 @default.
- W2011892883 hasConcept C54355233 @default.
- W2011892883 hasConcept C55493867 @default.
- W2011892883 hasConcept C71924100 @default.
- W2011892883 hasConcept C86803240 @default.
- W2011892883 hasConcept C95444343 @default.
- W2011892883 hasConceptScore W2011892883C136229726 @default.
- W2011892883 hasConceptScore W2011892883C141071460 @default.
- W2011892883 hasConceptScore W2011892883C142724271 @default.
- W2011892883 hasConceptScore W2011892883C170493617 @default.
- W2011892883 hasConceptScore W2011892883C185592680 @default.
- W2011892883 hasConceptScore W2011892883C207001950 @default.
- W2011892883 hasConceptScore W2011892883C2775960820 @default.
- W2011892883 hasConceptScore W2011892883C2777557582 @default.
- W2011892883 hasConceptScore W2011892883C2781411149 @default.
- W2011892883 hasConceptScore W2011892883C31695470 @default.
- W2011892883 hasConceptScore W2011892883C54355233 @default.
- W2011892883 hasConceptScore W2011892883C55493867 @default.
- W2011892883 hasConceptScore W2011892883C71924100 @default.