FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011894928> ?p ?o ?g. }

• W2011894928 endingPage "1414" @default.
• W2011894928 startingPage "1409" @default.
• W2011894928 abstract "Recent studies have suggested that nitric oxide (NO) synthase (NOS) may be localized in the urothelium of the proximal part of the mammalian ureter. We investigated endogenous NO production in the proximal half of the rat ureter, localized its cellular source, characterized the NOS isoforms involved and assessed the impact of NO on ureteral motility.Direct detection of NO production was performed on primary cultures of living rat ureteral cells with the fluorescent indicator diaminofluorescein. Cultures were incubated with the NO precursor L-arginine or the NOS inhibitors L-NAME (N-nitro-L-arginine-methyl ester) and 1400W. NOS expression was determined by immunofluorescence and Western blot analysis. The functional effects of NO donors were assessed on isolated ureters.Significant basal NO production was demonstrated by the high fluorescence level detected in diaminofluorescein treated cell cultures. NO production was strictly limited to urothelial cells since no fluorescence was seen in smooth muscle cells. Pretreatment with L-NAME or 1400W resulted in a significant decrease in fluorescence. Constitutive and inducible NOS isoforms were detected in urothelial cultured cells and in lysates of the urothelial layer. NO donors inhibited in a concentration dependent manner the agonist induced contractile activity of isolated ureters.These results suggest that NO production stems from the urothelium and the NO pathway inhibits contractile activity in the proximal half of the rat ureter. Hence, the nitrergic pathway may be an important target for drugs producing relaxation of the mammalian ureter." @default.
• W2011894928 created "2016-06-24" @default.
• W2011894928 creator A5006163142 @default.
• W2011894928 creator A5015618541 @default.
• W2011894928 creator A5023936525 @default.
• W2011894928 creator A5025395088 @default.
• W2011894928 creator A5072273408 @default.
• W2011894928 date "2003-10-01" @default.
• W2011894928 modified "2023-09-27" @default.
• W2011894928 title "Nitric Oxide Production Within Rat Urothelial Cells" @default.
• W2011894928 cites W1977032093 @default.
• W2011894928 cites W1978452581 @default.
• W2011894928 cites W1983260160 @default.
• W2011894928 cites W1994263840 @default.
• W2011894928 cites W2002708184 @default.
• W2011894928 cites W2007737411 @default.
• W2011894928 cites W2010055809 @default.
• W2011894928 cites W2016184733 @default.
• W2011894928 cites W2017644764 @default.
• W2011894928 cites W2024331637 @default.
• W2011894928 cites W2054996427 @default.
• W2011894928 cites W2066767319 @default.
• W2011894928 cites W2068899822 @default.
• W2011894928 cites W2083837316 @default.
• W2011894928 cites W2086767678 @default.
• W2011894928 cites W2089455960 @default.
• W2011894928 cites W2094837379 @default.
• W2011894928 cites W2167748258 @default.
• W2011894928 cites W4301350626 @default.
• W2011894928 doi "https://doi.org/10.1097/01.ju.0000083492.80217.20" @default.
• W2011894928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14501779" @default.
• W2011894928 hasPublicationYear "2003" @default.
• W2011894928 type Work @default.
• W2011894928 sameAs 2011894928 @default.
• W2011894928 citedByCount "21" @default.
• W2011894928 countsByYear W20118949282012 @default.
• W2011894928 countsByYear W20118949282014 @default.
• W2011894928 countsByYear W20118949282016 @default.
• W2011894928 countsByYear W20118949282017 @default.
• W2011894928 countsByYear W20118949282019 @default.
• W2011894928 countsByYear W20118949282020 @default.
• W2011894928 countsByYear W20118949282021 @default.
• W2011894928 countsByYear W20118949282023 @default.
• W2011894928 crossrefType "journal-article" @default.
• W2011894928 hasAuthorship W2011894928A5006163142 @default.
• W2011894928 hasAuthorship W2011894928A5015618541 @default.
• W2011894928 hasAuthorship W2011894928A5023936525 @default.
• W2011894928 hasAuthorship W2011894928A5025395088 @default.
• W2011894928 hasAuthorship W2011894928A5072273408 @default.
• W2011894928 hasConcept C104317684 @default.
• W2011894928 hasConcept C126322002 @default.
• W2011894928 hasConcept C126894567 @default.
• W2011894928 hasConcept C134018914 @default.
• W2011894928 hasConcept C153911025 @default.
• W2011894928 hasConcept C2776415932 @default.
• W2011894928 hasConcept C2776664737 @default.
• W2011894928 hasConcept C2777540882 @default.
• W2011894928 hasConcept C2777622882 @default.
• W2011894928 hasConcept C2779762690 @default.
• W2011894928 hasConcept C2910041100 @default.
• W2011894928 hasConcept C519581460 @default.
• W2011894928 hasConcept C54355233 @default.
• W2011894928 hasConcept C55493867 @default.
• W2011894928 hasConcept C71924100 @default.
• W2011894928 hasConcept C81885089 @default.
• W2011894928 hasConcept C85265743 @default.
• W2011894928 hasConcept C86803240 @default.
• W2011894928 hasConceptScore W2011894928C104317684 @default.
• W2011894928 hasConceptScore W2011894928C126322002 @default.
• W2011894928 hasConceptScore W2011894928C126894567 @default.
• W2011894928 hasConceptScore W2011894928C134018914 @default.
• W2011894928 hasConceptScore W2011894928C153911025 @default.
• W2011894928 hasConceptScore W2011894928C2776415932 @default.
• W2011894928 hasConceptScore W2011894928C2776664737 @default.
• W2011894928 hasConceptScore W2011894928C2777540882 @default.
• W2011894928 hasConceptScore W2011894928C2777622882 @default.
• W2011894928 hasConceptScore W2011894928C2779762690 @default.
• W2011894928 hasConceptScore W2011894928C2910041100 @default.
• W2011894928 hasConceptScore W2011894928C519581460 @default.
• W2011894928 hasConceptScore W2011894928C54355233 @default.
• W2011894928 hasConceptScore W2011894928C55493867 @default.
• W2011894928 hasConceptScore W2011894928C71924100 @default.
• W2011894928 hasConceptScore W2011894928C81885089 @default.
• W2011894928 hasConceptScore W2011894928C85265743 @default.
• W2011894928 hasConceptScore W2011894928C86803240 @default.
• W2011894928 hasIssue "4 Part 1" @default.
• W2011894928 hasLocation W20118949281 @default.
• W2011894928 hasLocation W20118949282 @default.
• W2011894928 hasOpenAccess W2011894928 @default.
• W2011894928 hasPrimaryLocation W20118949281 @default.
• W2011894928 hasRelatedWork W2008087125 @default.
• W2011894928 hasRelatedWork W2010868322 @default.
• W2011894928 hasRelatedWork W2039674246 @default.
• W2011894928 hasRelatedWork W2054818626 @default.
• W2011894928 hasRelatedWork W2089295326 @default.
• W2011894928 hasRelatedWork W2093911704 @default.
• W2011894928 hasRelatedWork W2114455877 @default.
• W2011894928 hasRelatedWork W2163475302 @default.

• next