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- W2011906543 abstract "Twelve patients with mild and 3 with severe hypereholesterolemia were stabilized with an isocaloric diet containing less than 300 mg cholesterol daily with a P/S ratio of 1.8, and placebo period of 4 weeks. They were administered 1000 mg probucol daily for 12 weeks, followed by placebo for 6 weeks. In patients with mild disease, a significant cholesterol reduction was achieved in serum, LDL, and HDL (maximum decrease, 17%, 13%, and 31%, respectively). While HDL3 cholesterol was reduced significantly throughout the period (P < 0.001), HDLZ cholesterol showed a significant decrease only at the 4th week of treatment (P < 0.001), and returned to basal levels at the 8th and 12th treatment weeks.Serum apo B levels decreased only slightly, but the HDL-apo A-I fall was significant with a reduction in the HDL-CH/HDL-apo A-I ratio throughout the treatment period.In 3 patients with severe disease, cholesterol decrease in serum and in VLDL, LDL and HDL fractions varied, but on the whole was lower than in patients with mild disease. A decrease in VLDL-CH and HDL-CH was present in all 3, but LDL-CH levels were only slightly lowered in 2 patients, and unchanged in the third.Serum probucol levels fell 66% from the 4th to the 12th treatment week, and in parallel, the percentage of lipoprotein-bound drug increased about 2-fold. It is suggested that these changes in pharmacokinetics as well as the cholesterol-lowering effect of the drug may be due to a change in lipoprotein composition or structure." @default.
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- W2011906543 date "1995-01-01" @default.
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- W2011906543 title "Metabolic effects of Captopril in hypertensive patients with noninsulin-dependent diabetes mellitus and hyperlipidemia" @default.
- W2011906543 doi "https://doi.org/10.1016/1043-6618(95)87561-1" @default.
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