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- W2011921403 abstract "A monoclonal antibody (MAb-HB55) directed against a HLA class II antigen (Ia), was purified by DE-52 chromatography. The purified MAb contained less than 5% impure protein detected by SDS-PAGE. Ricin was conjugated with the MAb via a disulfide bond to construct an immunotoxin (recin-HB55) The concentration causing fifty percent growth inhibition (IC50) was 2 × 10−11M for the Raji cells. In contrast, the IC50 for Molt-4 and K562 cells was 100 times higher than for the Raji cells. B lymphocytes separated from peripheral blood lymphocytes by nylon wool were selectively killed by the conjugate, but T lymphocytes were not apparently affected. Our results demonstrate that the immunotoxin is selectively cytotoxic to Raji cells and B-cells, and may have potential for purging malignant cells from bone marrow of patients with B-cell leukemia and lymphoma." @default.
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- W2011921403 date "1990-01-01" @default.
- W2011921403 modified "2023-09-25" @default.
- W2011921403 title "Selective killing of tumor cells in vitro by an immunotoxin composed of ricin and monoclonal antibody against Ia antigen" @default.
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- W2011921403 doi "https://doi.org/10.1016/0192-0561(90)90058-u" @default.
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