FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011921489> ?p ?o ?g. }

• W2011921489 endingPage "e108738" @default.
• W2011921489 startingPage "e108738" @default.
• W2011921489 abstract "The Escherichia coli species is divided in phylogenetic groups that differ in their virulence and commensal distribution. Strains belonging to the B2 group are involved in extra-intestinal pathologies but also appear to be more prevalent as commensals among human occidental populations. To investigate the genetic specificities of B2 sub-group, we used 128 sequenced genomes and identified genes of the core genome that showed marked difference between B2 and non-B2 genomes. We focused on the gene and its surrounding region with the strongest divergence between B2 and non-B2, the antiporter gene nhaA. This gene is part of the nhaAR operon, which is in the core genome but flanked by mobile regions, and is involved in growth at high pH and high sodium concentrations. Consistently, we found that a panel of non-B2 strains grew faster than B2 at high pH and high sodium concentrations. However, we could not identify differences in expression of the nhaAR operon using fluorescence reporter plasmids. Furthermore, the operon deletion had no differential impact between B2 and non-B2 strains, and did not result in a fitness modification in a murine model of gut colonization. Nevertheless, sequence analysis and experiments in a murine model of septicemia revealed that recombination in nhaA among B2 strains was observed in strains with low virulence. Finally, nhaA and nhaAR operon deletions drastically decreased virulence in one B2 strain. This effect of nhaAR deletion appeared to be stronger than deletion of all pathogenicity islands. Thus, a population genetic approach allowed us to identify an operon in the core genome without strong effect in commensalism but with an important role in extra-intestinal virulence, a landmark of the B2 strains." @default.
• W2011921489 created "2016-06-24" @default.
• W2011921489 creator A5006474715 @default.
• W2011921489 creator A5018025533 @default.
• W2011921489 creator A5023401251 @default.
• W2011921489 creator A5028480089 @default.
• W2011921489 creator A5039825248 @default.
• W2011921489 creator A5054554664 @default.
• W2011921489 creator A5058713041 @default.
• W2011921489 creator A5068809916 @default.
• W2011921489 creator A5078771800 @default.
• W2011921489 creator A5081134363 @default.
• W2011921489 creator A5086858369 @default.
• W2011921489 date "2014-09-30" @default.
• W2011921489 modified "2023-10-17" @default.
• W2011921489 title "The Conserved nhaAR Operon Is Drastically Divergent between B2 and Non-B2 Escherichia coli and Is Involved in Extra-Intestinal Virulence" @default.
• W2011921489 cites W1523663652 @default.
• W2011921489 cites W1541707791 @default.
• W2011921489 cites W1650035715 @default.
• W2011921489 cites W1964328764 @default.
• W2011921489 cites W1980310800 @default.
• W2011921489 cites W1992050568 @default.
• W2011921489 cites W2000197351 @default.
• W2011921489 cites W2001921028 @default.
• W2011921489 cites W2003625275 @default.
• W2011921489 cites W2006492816 @default.
• W2011921489 cites W2017404719 @default.
• W2011921489 cites W2029848310 @default.
• W2011921489 cites W2038186289 @default.
• W2011921489 cites W2042256181 @default.
• W2011921489 cites W2050976530 @default.
• W2011921489 cites W2061448692 @default.
• W2011921489 cites W2064560838 @default.
• W2011921489 cites W2095724872 @default.
• W2011921489 cites W2104384253 @default.
• W2011921489 cites W2106814707 @default.
• W2011921489 cites W2113212441 @default.
• W2011921489 cites W2116137883 @default.
• W2011921489 cites W2116411437 @default.
• W2011921489 cites W2120211414 @default.
• W2011921489 cites W2121695290 @default.
• W2011921489 cites W2122281944 @default.
• W2011921489 cites W2125201618 @default.
• W2011921489 cites W2125591244 @default.
• W2011921489 cites W2135663335 @default.
• W2011921489 cites W2142402047 @default.
• W2011921489 cites W2142586833 @default.
• W2011921489 cites W2146400406 @default.
• W2011921489 cites W2148070420 @default.
• W2011921489 cites W2150221406 @default.
• W2011921489 cites W2153630211 @default.
• W2011921489 cites W2159279413 @default.
• W2011921489 cites W2161199331 @default.
• W2011921489 cites W2162636530 @default.
• W2011921489 cites W2167965269 @default.
• W2011921489 cites W2171580909 @default.
• W2011921489 cites W2172147152 @default.
• W2011921489 doi "https://doi.org/10.1371/journal.pone.0108738" @default.
• W2011921489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4182557" @default.
• W2011921489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25268639" @default.
• W2011921489 hasPublicationYear "2014" @default.
• W2011921489 type Work @default.
• W2011921489 sameAs 2011921489 @default.
• W2011921489 citedByCount "13" @default.
• W2011921489 countsByYear W20119214892015 @default.
• W2011921489 countsByYear W20119214892016 @default.
• W2011921489 countsByYear W20119214892017 @default.
• W2011921489 countsByYear W20119214892021 @default.
• W2011921489 countsByYear W20119214892023 @default.
• W2011921489 crossrefType "journal-article" @default.
• W2011921489 hasAuthorship W2011921489A5006474715 @default.
• W2011921489 hasAuthorship W2011921489A5018025533 @default.
• W2011921489 hasAuthorship W2011921489A5023401251 @default.
• W2011921489 hasAuthorship W2011921489A5028480089 @default.
• W2011921489 hasAuthorship W2011921489A5039825248 @default.
• W2011921489 hasAuthorship W2011921489A5054554664 @default.
• W2011921489 hasAuthorship W2011921489A5058713041 @default.
• W2011921489 hasAuthorship W2011921489A5068809916 @default.
• W2011921489 hasAuthorship W2011921489A5078771800 @default.
• W2011921489 hasAuthorship W2011921489A5081134363 @default.
• W2011921489 hasAuthorship W2011921489A5086858369 @default.
• W2011921489 hasBestOaLocation W20119214891 @default.
• W2011921489 hasConcept C104317684 @default.
• W2011921489 hasConcept C141231307 @default.
• W2011921489 hasConcept C144024400 @default.
• W2011921489 hasConcept C149923435 @default.
• W2011921489 hasConcept C193252679 @default.
• W2011921489 hasConcept C203075996 @default.
• W2011921489 hasConcept C22744801 @default.
• W2011921489 hasConcept C2780258820 @default.
• W2011921489 hasConcept C2908647359 @default.
• W2011921489 hasConcept C54355233 @default.
• W2011921489 hasConcept C547475151 @default.
• W2011921489 hasConcept C60987743 @default.
• W2011921489 hasConcept C62130838 @default.
• W2011921489 hasConcept C86803240 @default.
• W2011921489 hasConcept C89423630 @default.
• W2011921489 hasConceptScore W2011921489C104317684 @default.

• next