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• W2011923462 abstract "We tested primary breast carcinoma tissues from 297 patients using a monoclonal antibody (clone 235-1.7.1.) for the expression of p21ras. 58% of tumors were p21ras-positive. When calculated in a univariate fashion, p21 expression correlated with proliferation activity (proliferating cell nuclear antigen) only. Using the log-rank test (median observation time 94 months) a significantly worse prognosis (disease-free survival, overall survival) relation was found with larger tumors, nodal involvement, anaplasia, rising proliferation activity, and lack of steroid receptors. Detection of p21ras correlated with a more favorable prognosis but only in node-negative patients. Stepwise correlation according to the Cox hazard model ranked p21 expression as a most significant predictor of prognosis second only to nodal status. These data suggest that detection of p21ras indicates the presence of a parameter which may act as tumor suppressor and benefit patients’ survival." @default.
• W2011923462 created "2016-06-24" @default.
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• W2011923462 date "1999-01-01" @default.
• W2011923462 modified "2023-10-18" @default.
• W2011923462 title "Immunohistochemical Detection of H-ras Protooncoprotein p21 Indicates Favorable Prognosis in Node-Negative Breast Cancer Patients" @default.
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• W2011923462 doi "https://doi.org/10.1159/000030061" @default.
• W2011923462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10393527" @default.
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