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- W2011924166 abstract "Transglutaminase 2 (TGase 2) is over-expressed in a variety of inflammatory diseases including allergic asthma. TGase 2 inhibitors block TGase 2 over-expression. This study aimed to investigate whether TGase 2-/- protects against airway inflammation and tissue remodeling associated with OVA-induced allergic asthma in mice. C57BL/6 or TGase 2-/- mice were sensitized and challenged with OVA to induce asthma. OVA-specific serum IgE and leukotrienes (LTs) levels were measured by ELISA, and the recruitment of inflammatory cells into BAL fluid or lung tissues was stained with Diff-Quik and H & E, goblet cell hyperplasia by PAS. AHR was determined in a whole body plethysmographic chamber. Expression of TGase 2, eosinophil major basic protein (EMBP), VCAM-1, Muc5ac, PLA2 protein was measured by Western blotting while mRNA levels of Muc5ac, cytokines, MMPs, and TIMPs were quantified by RT-PCR. NF-B levels were evaluated by EMSA. TGase 2-/- protected against OVA-specific IgE production, the recruitment of total inflammatory cells, macrophages, neutrophils, lymphocytes and eosinophils in BAL fluid. TGase 2-/- reduced the number of goblet cells, AHR; expression of EMBP, Muc5ac, VCAM-1, CD40/CD40L; mRNA levels of several cytokines and chemokines, NF-B activity, PLA2 expression, and LTs levels in BAL cells and lung tissues. Expression of TIMP1/2 was recovered with TGase 2-/-. Our data suggest that TGase 2-/- protects against the expression of numerous molecules associated with airway inflammation and remodeling by suppressing NF-B activation, and that TGase 2 may be a potential therapeutic target for treating allergic asthma." @default.
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- W2011924166 date "2012-02-01" @default.
- W2011924166 modified "2023-09-28" @default.
- W2011924166 title "Transglutaminase 2 Knock-out Protects Against Airway Inflammation And Tissue Remodeling In Ova-specific Allergic Asthma In Mice" @default.
- W2011924166 doi "https://doi.org/10.1016/j.jaci.2011.12.695" @default.
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