FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011931369> ?p ?o ?g. }

• W2011931369 endingPage "166" @default.
• W2011931369 startingPage "155" @default.
• W2011931369 abstract "The nucleus accumbens shell (NAcS) has been implicated in controlling stress responses through corticotropin-releasing factor (CRF). In addition to studies indicating that CRF in the NAcS increases appetitive motivation, there is indirect evidence suggesting that NAcS CRF may also cause aversive responses and that these behaviors may be mediated through local dopamine (DA) and acetylcholine (ACh) systems. To provide a direct test of this hypothesis, we used male Sprague–Dawley rats with implanted cannulas aimed at the NAcS. Experiment 1 showed local CRF injection (10 or 50 ng/side) to increase immobility in the forced swim test and a CRF antagonist D-Phe-CRF (12-41) to attenuate this depressive-like behavior. In Experiment 2, injection of CRF (250 ng/side) also decreased the rats' preference for sucrose, while in Experiment 3, CRF (50 or 250 ng/side) induced anxiety-like behaviors in an elevated plus maze and open field. These same doses of CRF in Experiment 4 failed to alter the rats' locomotor activity, indicating that these behavioral changes were not caused by deficits in activity. In Experiment 5, results from in vivo microdialysis revealed that CRF in the NAcS markedly increased local extracellular ACh, while also producing a small increase in DA. These results show that NAcS CRF can generate a variety of aversive behaviors, including swim depression, anhedonia, and anxiety, in addition to approach behavior. They suggest that these behaviors may occur, in part, through enhanced activation of ACh and DA in the NAcS, respectively, supporting a role for this brain area in mediating the dual effects of stress." @default.
• W2011931369 created "2016-06-24" @default.
• W2011931369 creator A5014318250 @default.
• W2011931369 creator A5031932651 @default.
• W2011931369 creator A5064686760 @default.
• W2011931369 creator A5086917610 @default.
• W2011931369 creator A5090507281 @default.
• W2011931369 date "2012-03-01" @default.
• W2011931369 modified "2023-10-03" @default.
• W2011931369 title "Corticotropin-releasing factor in the nucleus accumbens shell induces swim depression, anxiety, and anhedonia along with changes in local dopamine/acetylcholine balance" @default.
• W2011931369 cites W1543478231 @default.
• W2011931369 cites W1789705209 @default.
• W2011931369 cites W1928329059 @default.
• W2011931369 cites W1960639209 @default.
• W2011931369 cites W1965420710 @default.
• W2011931369 cites W1966856371 @default.
• W2011931369 cites W1969047053 @default.
• W2011931369 cites W1971675083 @default.
• W2011931369 cites W1973590159 @default.
• W2011931369 cites W1976602194 @default.
• W2011931369 cites W1977102147 @default.
• W2011931369 cites W1978814025 @default.
• W2011931369 cites W1980890656 @default.
• W2011931369 cites W1985387196 @default.
• W2011931369 cites W1985693247 @default.
• W2011931369 cites W1988967920 @default.
• W2011931369 cites W1991825538 @default.
• W2011931369 cites W1995757367 @default.
• W2011931369 cites W2000274215 @default.
• W2011931369 cites W2002388820 @default.
• W2011931369 cites W2005020429 @default.
• W2011931369 cites W2005097389 @default.
• W2011931369 cites W2006521913 @default.
• W2011931369 cites W2010370084 @default.
• W2011931369 cites W2010569444 @default.
• W2011931369 cites W2013713160 @default.
• W2011931369 cites W2017423239 @default.
• W2011931369 cites W2022062211 @default.
• W2011931369 cites W2024536090 @default.
• W2011931369 cites W2025294582 @default.
• W2011931369 cites W2026344745 @default.
• W2011931369 cites W2027729485 @default.
• W2011931369 cites W2028217516 @default.
• W2011931369 cites W2030342407 @default.
• W2011931369 cites W2033746591 @default.
• W2011931369 cites W2035590629 @default.
• W2011931369 cites W2042186726 @default.
• W2011931369 cites W2044246448 @default.
• W2011931369 cites W2045077362 @default.
• W2011931369 cites W2051591579 @default.
• W2011931369 cites W2052922750 @default.
• W2011931369 cites W2054533889 @default.
• W2011931369 cites W2054798683 @default.
• W2011931369 cites W2065673262 @default.
• W2011931369 cites W2065714116 @default.
• W2011931369 cites W2066841079 @default.
• W2011931369 cites W2066857239 @default.
• W2011931369 cites W2069472087 @default.
• W2011931369 cites W2070372928 @default.
• W2011931369 cites W2071385825 @default.
• W2011931369 cites W2072023349 @default.
• W2011931369 cites W2072074091 @default.
• W2011931369 cites W2072810539 @default.
• W2011931369 cites W2073718251 @default.
• W2011931369 cites W2073918749 @default.
• W2011931369 cites W2074706828 @default.
• W2011931369 cites W2076383088 @default.
• W2011931369 cites W2076457657 @default.
• W2011931369 cites W2082827602 @default.
• W2011931369 cites W2090204531 @default.
• W2011931369 cites W2093145540 @default.
• W2011931369 cites W2095036452 @default.
• W2011931369 cites W2103249556 @default.
• W2011931369 cites W2104433615 @default.
• W2011931369 cites W2106767458 @default.
• W2011931369 cites W2113375740 @default.
• W2011931369 cites W2132465696 @default.
• W2011931369 cites W2141467587 @default.
• W2011931369 cites W2149823377 @default.
• W2011931369 cites W2156782574 @default.
• W2011931369 cites W2169250701 @default.
• W2011931369 cites W2172157844 @default.
• W2011931369 cites W4376848280 @default.
• W2011931369 doi "https://doi.org/10.1016/j.neuroscience.2011.12.009" @default.
• W2011931369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22245501" @default.
• W2011931369 hasPublicationYear "2012" @default.
• W2011931369 type Work @default.
• W2011931369 sameAs 2011931369 @default.
• W2011931369 citedByCount "63" @default.
• W2011931369 countsByYear W20119313692012 @default.
• W2011931369 countsByYear W20119313692013 @default.
• W2011931369 countsByYear W20119313692014 @default.
• W2011931369 countsByYear W20119313692015 @default.
• W2011931369 countsByYear W20119313692016 @default.
• W2011931369 countsByYear W20119313692017 @default.
• W2011931369 countsByYear W20119313692018 @default.
• W2011931369 countsByYear W20119313692019 @default.
• W2011931369 countsByYear W20119313692020 @default.

• next